Abstract
We report a case of thoracic air-leak syndrome, an extremely rare complication developed after an episode of organizing pneumonia due to graft-vs-host disease in a 19-year-old male. This unusual non-infectious pulmonary complication occurred 527 days after allogeneic HSCT and led to the patient’s death within 1 month due to cardio-respiratory failure. Herein, we highlight chest-imaging aspects which are typical. Early detection by high-resolution chest CT could improve patient management.
Similar content being viewed by others
References
Franquet T, Giménez A, Torrubia S, Sabaté JM, Rodriguez-Arias JM (2000) Spontaneous pneumothorax and pneumomediastinum in IPF. Eur Radiol 10(1):108–113
Moon MH, Sa YJ, Cho KD, Jo KH, Lee SH, Sim SB (2010) Thoracic air-leak syndromes in hematopoietic stem cell transplant recipients with graft-versus-host disease: a possible sign for poor response to treatment and poor prognosis. J Korean Med Sci 25(5):658–662
Vogel M, Brodoefel H, Bethge W, Faul C, Hartmann J, Schimmel H et al (2006) Spontaneous thoracic air-leakage syndrome in patients following allogeneic hematopoietic stem cell transplantation: causes, CT-follow up and patient outcome. Eur J Radiol 60(3):392–397
Toubai T, Tanaka J, Kobayashi N, Honda T, Miura Y, Ogawa T et al (2004) Mediastinal emphysema and bilateral pneumothoraces with chronic GVHD in patients after allogeneic stem cell transplantation. Bone Marrow Transplant 33(11):1159–1163
Sakai R, Kanamori H, Nakaseko C, Yoshiba F, Fujimaki K, Sakura T et al (2011) Air-leak syndrome following allo-SCT in adult patients: report from the Kanto Study Group for Cell Therapy in Japan. Bone Marrow Transplant 46(3):379–384
Bergeron A (2017) Late-onset noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation. Clin Chest Med 38(2):249–262
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Informed Consent
Informed consent was obtained from parents because the person described in the case report has died.
Rights and permissions
About this article
Cite this article
Boghanim, T., Murris, M., Lamon, T. et al. Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation. Lung 197, 101–103 (2019). https://doi.org/10.1007/s00408-018-0173-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00408-018-0173-z