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Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review

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Abstract

Chronic airway inflammatory diseases remain a major problem worldwide, such that there is a need for additional therapeutic targets and novel drugs. Transient receptor potential (TRP) channels are a group of non-selective cation channels expressed throughout the body that are regulated by various stimuli. TRP channels have been identified in numerous cell types in the respiratory tract, including sensory neurons, airway epithelial cells, airway smooth muscle cells, and fibroblasts. Different types of TRP channels induce cough in sensory neurons via the vagus nerve. Permeability and cytokine production are also regulated by TRP channels in airway epithelial cells, and these channels also contribute to the modulation of bronchoconstriction. TRP channels may cooperate with other TRP channels, or act in concert with calcium-dependent potassium channels and calcium-activated chloride channel. Hence, TRP channels could be the potential therapeutic targets for chronic airway inflammatory diseases. In this review, we aim to discuss the expression profiles and physiological functions of TRP channels in the airway, and the roles they play in chronic airway inflammatory diseases.

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Funding

This work was supported by the National Natural Science Foundation of China (81500012), the Zhejiang Provincial Natural Science Foundation of China (LQ16H010001), the Medical and Health Technology Program of Zhejiang Province (2015111464, 2017204226) and the Program of Zhejiang Province Health High-level Personnel (2017) to Yang Xia.

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  1. Yang Xia and Lexin Xia contributed equally to this work.

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  1. Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China

    Yang Xia, Lexin Xia, Lingyun Lou, Rui Jin, Huahao Shen & Wen Li

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  1. Yang Xia
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Xia, Y., Xia, L., Lou, L. et al. Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review. Lung 196, 505–516 (2018). https://doi.org/10.1007/s00408-018-0145-3

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