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Elevated midline-parietal gamma band noise power in schizophrenia but not in bipolar patients

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Abstract

Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and cognition in schizophrenia. In the current study, we sought to replicate those findings and to study its specificity for schizophrenia in a completely independent sample. A principal component analysis (PCA) was used to determine the factorial structure of gamma noise power acquired with an electroencephalographic recording during an odd-ball P300 paradigm in the 250- to 550-ms window in 70 patients with schizophrenia (16 patients with first episode), 45 bipolar patients and 65 healthy controls. Clinical and cognitive correlates of the resulting factors were also assessed. Three factors arose from the PCA. The first displayed a midline-parietal distribution (roughly corresponding to the default mode network), the second was centro-temporal and the third anterior–frontal. Schizophrenia but not bipolar patients showed higher gamma noise power loadings in the first factor in comparison with controls. Scores for this factor were significantly and directly associated with positive and total symptoms in patients and inversely associated with global cognition in all participants. The results of this study replicate those of our previous publication and suggest an elevated midline-parietal gamma noise power specific to schizophrenia. The gamma noise power measure seems to be a useful tool for studying background oscillatory activity during performance of cognitive tasks.

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Acknowledgments

The present work was supported in part by the Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III) (FIS PI080017, FIS PI1102303) and the Gerencia Regional de Salud de Castilla y León (GRS 249/A/08, GRS 613/A/11) Grants to V. Molina; a predoctoral scholarship from the University of Salamanca and Santander Bank to V. Suazo; a predoctoral scholarship from Consejería de Educación-Junta de Castilla y León and European Social Fund to A. Lubeiro; and Grants to T. Palomo and R. Rodriguez-Jimenez from the Fondo de Investigaciones Sanitarias (Instituto de Salud Carlos III) (FIS PI080514), Madrid’s Regional Government (S2010/BMD-2422 AGES) and the European Union Structural Funds, and the Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) of the Instituto de Salud Carlos III. All authors have approved the final manuscript

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Authors and Affiliations

  1. Psychiatry Research Unit, University Hospital of Álava, Osakidetza, CIBERSAM, Vitoria, Spain

    Vanessa Suazo

  2. Psychiatry Department, Faculty of Medicine, University of Valladolid, Valladolid, Spain

    Alba Lubeiro & Vicente Molina

  3. Department of Psychiatry, Instituto de Investigación 12 de Octubre (i+12), Madrid, Spain

    Rosa Jurado-Barba, Marta Moreno-Ortega, Mónica Dompablo, Isabel Morales-Muñoz, Roberto Rodriguez-Jimenez & Tomas Palomo

  4. Department of Psychology, Faculty of Health Sciences, Camilo Jose Cela University, Madrid, Spain

    Rosa Jurado-Barba

  5. New York State Psychiatric Institute, Columbia University, New York, NY, USA

    Marta Moreno-Ortega

  6. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain

    Roberto Rodriguez-Jimenez, Tomas Palomo & Vicente Molina

  7. Psychiatry Department, Faculty of Medicine, UCM, Madrid, Spain

    Roberto Rodriguez-Jimenez & Tomas Palomo

  8. Psychiatry Service, University Hospital of Valladolid, University of Valladolid, Avenida de Ramón y Cajal, 7, 48005, Valladolid, Spain

    Vicente Molina

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  1. Vanessa Suazo
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  2. Alba Lubeiro
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Correspondence to Vicente Molina.

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Suazo, V., Lubeiro, A., Jurado-Barba, R. et al. Elevated midline-parietal gamma band noise power in schizophrenia but not in bipolar patients. Eur Arch Psychiatry Clin Neurosci 266, 743–753 (2016). https://doi.org/10.1007/s00406-016-0673-x

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