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Lung metastases in newly diagnosed hypopharyngeal cancer: a population-based study

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Abstract

Purpose

Current population-based estimates of the incidence and prognosis of lung metastases of hypopharyngeal cancer are lacking. The purpose of the study is to characterize the incidence proportions and survival probability of patients with hypopharyngeal cancer and lung metastases.

Materials and methods

We identified 2714 adult patients diagnosed with hypopharyngeal cancer between 2010 and 2014 for whom the status of lung metastases was known from the SEER database. Multivariable logistic and Cox regression models were performed to identify the risk factors associated with the presence of lung metastases at diagnosis and 5-year all-cause mortality, respectively.

Results

We identified 128 patients with lung metastases at the time of diagnosis of hypopharyngeal cancer. Females were less likely to have lung metastases. Incidences of lung metastases were higher among patients with histological grade III/IV. For each 10 mm increase in tumor size, the odds of having lung metastases increased by 6.6%. Patients with lung metastases had a shorter survival time.

Conclusion

Our study provides insight into the epidemiology of lung metastases in patients with hypopharyngeal cancer. When the tumor is diagnosed, we should pay close attention to the sex, race, tumor size and histological grade to quickly detect the distant metastases.

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Acknowledgements

We thank Arthur Gewei Liu who as a native speaker proofread this paper.

Funding

None.

Author information

Author notes

  1. Na Shen and Tao Li contributed equally to this work.

Authors and Affiliations

  1. Department of Otolaryngology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    Na Shen, Lei Zhou & Xu Zhou

  2. Department of Otolaryngology, Peking University Third Hospital, Peking University, 49 North Huayuan Road, Beijing, 100191, China

    Tao Li

Authors
  1. Na Shen
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  2. Tao Li
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  3. Lei Zhou
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  4. Xu Zhou
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Contributions

Data collection and statistical works were done by NS, TL and LZ. XZ contributed to the paper design. The paper was written by XZ and NS.

Corresponding author

Correspondence to Xu Zhou.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the institutional review board at Zhongshan Hospital of Fudan University. Since it was a secondary analysis based on an existing database, written and informed consent was waived.

Data availability statement

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Shen, N., Li, T., Zhou, L. et al. Lung metastases in newly diagnosed hypopharyngeal cancer: a population-based study. Eur Arch Otorhinolaryngol 278, 4469–4476 (2021). https://doi.org/10.1007/s00405-021-06675-y

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  • DOI: https://doi.org/10.1007/s00405-021-06675-y

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