Abstract
Purpose
To measure the duration of nasolacrimal transition in patients with Multiple Sclerosis (MS), to compare the findings with the healthy population and to investigate the relationship between MS-related disability and nasolacrimal transition time.
Methods
A total of 73 individuals including 37 patients with relapsing–remitting MS and 36 healthy volunteers were included in the study. In both groups the nasolacrimal transition time was measured using flurosein drops. The degree of disability of MS patients was calculated according to the Expanded Disability Status Scale (EDSS).
Results
There was a significant difference between MS patients and control group in terms of the median value of nasolacrimal transition time in (240 s (min: 85, max: 724) and 58.5 s (min: 21, max: 428), respectively) (p < 0.001). A positive correlation was found between EDSS scores and nasolacrimal transition time of MS patients (r = 0.384, p = 0.019).
Conclusion
This study showed that nasolacrimal transition time is prolonged in MS patients and there is a relationship between the degree of MS-related disability and the nasolacrimal transition time. This is the first study in the literature on this subject and the results of our study have the potential to shed light on the causes of common infections in MS patients. Long-term prospective studies are needed to further investigate the relationship between prolonged nasolacrimal transition and infections in MS patients.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Yozgat Bozok University Clinical Researches Ethic Committee Ref No: 2017-KAEK-189ˍ2019.12.25ˍ14) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Dağıstan, H., Hamamcı, M. Nasolacrimal transition time in patients with multiple sclerosis. Eur Arch Otorhinolaryngol 278, 3357–3362 (2021). https://doi.org/10.1007/s00405-021-06603-0
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DOI: https://doi.org/10.1007/s00405-021-06603-0