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Olfactory function and olfactory bulb volume in Wilson’s disease

  • Rhinology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson’s Disease (WD) patients.

Methods

A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.

Results

There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05).

Conclusions

WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.

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References

  1. Salari M, Fayyazi E, Mirmosayyeb O (2018) Magnetic resonance imaging findings in diagnosis and prognosis of Wilson disease. J Res Med Sci 23:23. https://doi.org/10.4103/jrms.JRMS_362_16

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mueller A, Reuner U, Landis B, Kitzler H, Reichmann H, Hummel T (2006) Extrapyramidal symptoms in Wilson’s disease are associated with olfactory dysfunction. Mov Disord 21(9):1311–1316. https://doi.org/10.1002/mds.20989

    Article  PubMed  Google Scholar 

  3. Passali GC, Bove F, Vargiu L, Bentivoglio AR, Anzivino R, De Corso E, Galli J, Rigante M, Pandolfini M, Sergi B, Giuliani M, Cianfrone F, Paludetti G, Fasano A (2017) New olfactometric findings in Parkinson’s disease. Clin Otolaryngol 42(4):837–843. https://doi.org/10.1111/coa.12816

    Article  CAS  PubMed  Google Scholar 

  4. Cain WS, Gent JF, Goodspeed RB, Leonard G (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 98(1):83–88. https://doi.org/10.1288/00005537-198801000-00017

    Article  CAS  PubMed  Google Scholar 

  5. Veyseller B, Ozucer B, Karaaltin AB, Yildirim Y, Degirmenci N, Aksoy F, Ozturan O (2014) Connecticut (CCCRC) olfactory test: normative values in 426 healthy volunteers. Indian J Otolaryngol Head Neck Surg 66(1):31–34. https://doi.org/10.1007/s12070-013-0632-z

    Article  PubMed  Google Scholar 

  6. Veyseller B, Ozucer B, Degirmenci N, Gurbuz D, Tambas M, Altun M, Aksoy F, Ozturan O (2014) Olfactory bulb volume and olfactory function after radiotherapy in patients with nasopharyngeal cancer. Auris Nasus Larynx 41 (5):436–440. https://doi.org/10.1016/j.anl.2014.02.004

    Article  PubMed  Google Scholar 

  7. Veyseller B, Ozucer B, Aksoy F, Yildirim YS, Gurbuz D, Balikci HH, Ozturan O (2012) Reduced olfactory bulb volume and diminished olfactory function in total laryngectomy patients: a prospective longitudinal study. Am J Rhinol Allergy 26(3):191–193. https://doi.org/10.2500/ajra.2012.26.3768

    Article  PubMed  Google Scholar 

  8. Hummel T, Haehner A, Hummel C, Croy I, Iannilli E (2013) Lateralized differences in olfactory bulb volume relate to lateralized differences in olfactory function. Neuroscience 237:51–55. https://doi.org/10.1016/j.neuroscience.2013.01.044

    Article  CAS  PubMed  Google Scholar 

  9. Wilson RS, Arnold SE, Schneider JA, Tang Y, Bennett DA (2007) The relationship between cerebral Alzheimer’s disease pathology and odour identification in old age. J Neurol Neurosurg Psychiatry 78(1):30–35. https://doi.org/10.1136/jnnp.2006.099721

    Article  CAS  PubMed  Google Scholar 

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Funding

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology and Head and Neck Surgery, Bezmialem Vakif University, Istanbul, Turkey

    Nazan Degirmenci & Orhan Ozturan

  2. Department of Otorhinolaryngology and Head and Neck Surgery, Medical Faculty, Acibadem University, Istanbul, Turkey

    Bayram Veyseller

  3. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Hasmet Hanagasi & Basar Bilgic

  4. Department of Radiology, Okmeydani Training and Research Hospital, Istanbul, Turkey

    Defne Gurbuz

  5. Department of Biostatistics and Medical Informatics, Bezmialem Vakif University, Istanbul, Turkey

    Ali Toprak

Authors
  1. Nazan Degirmenci
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  2. Bayram Veyseller
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  3. Hasmet Hanagasi
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  4. Basar Bilgic
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  5. Defne Gurbuz
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  6. Ali Toprak
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  7. Orhan Ozturan
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Corresponding author

Correspondence to Nazan Degirmenci.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Degirmenci, N., Veyseller, B., Hanagasi, H. et al. Olfactory function and olfactory bulb volume in Wilson’s disease. Eur Arch Otorhinolaryngol 276, 139–142 (2019). https://doi.org/10.1007/s00405-018-5216-9

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  • DOI: https://doi.org/10.1007/s00405-018-5216-9

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