Abstract
Purpose
There are no randomized trials comparing the incidence or severity of facial nerve dysfunction after superficial parotidectomy with or without continuous intraoperative electromyographic neuromonitoring. This pilot study aimed to assess the variability in outcomes to help determine the needs and possible ethical issues in a full-scale study.
Methods
Prospective randomized pilot study comparing the incidence and grade of facial nerve dysfunction among 106 patients subjected to superficial parotidectomy with or without continuous four channels electromyographic neuromonitoring (52 monitored patients and 54 controls).
Results
The incidences of immediate (38.3% vs. 51.8%, p = 0.1) and late facial dysfunction, up to 180 days following surgery, (3.8% vs. 5.5%, p = 0.4) were similar between monitored patients and controls. Immediate facial nerve dysfunction with a House–Brackmann ≥ grade III was more frequent among the non-monitored patients (57.8% vs. 30%, p = 0.2), and outcomes were significantly poorer in this group (mean sum score of 68.7 vs. 81.5, p = 0.002), when assessed with the regional Sunnybrook scale. A full-scale prospective randomized study to detect a significant reduction in the incidence of immediate facial nerve dysfunction with the use of continuous intraoperative electromyographic neuromonitoring, with 80% power and a 5% significant level, would require 560 patients allocated to the monitored and control groups. Considering a mean rate of 30 patients/year/center, such a study would require the participation of five centers for 4 years.
Conclusions
In the present pilot study, the incidences of immediate and late facial nerve dysfunction were similar between patients with benign parotid tumors subjected to superficial parotidectomy with or without continuous intraoperative electromyographic neuromonitoring. However, immediate facial dysfunction was more severe among the non-monitored patients.
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References
Bradley PJ, McGurk M (2013) Incidence of salivary gland neoplasms in a defined UK population. Br J Oral Maxillofac Surg 51(5):399–403
Mifsud M, Eskander A, Irish J et al (2017) Evolving trends in head and neck cancer epidemiology: Ontario, Canada 1993–2010. Head Neck 39(9):1770–1778
Gao M, Hao Y, Huang MX et al (2017) Salivary gland tumors in a northern Chinese population: a 50-year retrospective study of 7190 cases. Int J Oral Maxillofac Surg 46(3):343–349
Snow GB (2001) The surgical approaches to the treatment of parotid pleomorphic adenomas. In: McGurk M, Renehan AG (eds) Controversies in the management of salivary gland disease. Oxford University Press, Oxford, p 58
Xie S, Wang K, Xu H, Hua RX, Li TZ, Shan XF, Cai ZG (2015) PRISMA-extracapsular dissection versus superficial parotidectomy in treatment of benign parotid tumors: evidence from 3194 patients. Medicine (Baltimore) 94(34):e1237. https://doi.org/10.1097/MD.0000000000001237
Witt RL (1999) Facial nerve function after partial superficial parotidectomy: an 11-year review. Otolaryngol Head Neck Surg 121(3):210–213
Patey DH (1963) Risk of facial paralysis after parotidectomy. Br Med J 2(5365):1100–1102
Dulguerov P, Marchal F, Lehmann W (1999) Postparotidectomy facial nerve paralysis: possible etiologic factors and results with routine facial nerve monitoring. Laryngoscope 109(5):754–762
Patey DH, Moffat W (1962) A clinical and experimental study of functional paralysis of the facial nerve following conservative parotidectomy. Br J Surg 48:435–440
Krause F (1912) Introductory remarks in physiology. In: Krause F, Thorek M (eds) Surgery of the brain and spinal cord based on personal experience, vol II. Rebman Company, New York, pp 283–296
Dillon FX (2010) Electromyographic (EMG) neuromonitoring in otolaryngology head and neck surgery. Anesthesiol Clin 28(3):423–442
Eisele DW, Wang SJ, Orloff LA (2010) Electrophysiologic facial nerve monitoring during parotidectomy. Head Neck 32(3):399–405
Hopkins C, Khemani S, Terry RM, Golding-Wood D (2005) How we do it: nerve monitoring in ENT surgery: current UK practice. Clin Otolaryngol 30(2):195–198
Lowry TR, Gal TJ, Brennan JA (2005) Patterns of use of facial nerve monitoring during parotid gland surgery. Otolaryngol Head Neck Surg 133(3):313–318
Sood AJ, Houlton JJ, Nguyen SA, Gillespie MB (2005) Facial nerve monitoring during parotidectomy: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 152(4):631–637
Whitehead AL, Julious SA, Cooper CL, Campbell MJ (2016) Estimating the sample size for a pilot randomized trial to minimize the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Stat Methods Med Res 25(3):1057–1073
Watanabe Y, Ishikawa M, Shojaku H, Mizukoshi K (1993) Facial nerve palsy as a complication of parotid gland surgery and its prevention. Acta Otolaryngol Suppl 504:137–139
Bittar RF, Ferraro HP, Ribas MH, Lehn CN (2016) Facial paralysis after superficial parotidectomy: analysis of possible predictors of this complication. Braz J Otorhinolaryngol 82(4):447–451
Perzik SL (1954) Facial nerve paresis in parotid surgery. Surgery 36(4):751–761
Mra Z, Komisar A, Blaugrund SM (1993) Functional facial nerve weakness after surgery for benign parotid tumors: a multivariate statistical analysis. Head Neck 15(2):147–152
Guntinas-Lichius O, Gabriel B, Klussmann JP (2006) Risk of facial palsy and severe Frey’s syndrome after conservative parotidectomy for benign disease: analysis of 610 operations. Acta Otolaryngol 126(10):1104–1109
Wang SJ, Eisele DW (2007) Superficial parotidectomy. In: Myers EN, Ferris RL (eds) Salivary gland disorders. Springer, Berlin, pp 237–246
Thiede O, Klüsener T, Sielenkämper A, Van Aken H, Stoll W, Schmäl F (2006) Interference between muscle relaxation and facial nerve monitoring during parotidectomy. Acta Otolaryngol 126(4):422–428
House JW, Brackmann DE (1985) Facial nerve grading system. Otolaryngol Head Neck Surg 93(2):146–147
Ross BG, Fradet G, Nedzelski JM (1996) Development of a sensitive clinical facial grading system. Otolaryngol Head Neck Surg 114(3):380–386
VanSwearingen JM, Brach JS (1996) The Facial Disability Index: reliability and validity of a disability assessment instrument for disorders of the facial neuromuscular system. Phys Ther 76(12):1288–1298
Deans GT, Briggs K, Spence RA (1995) An audit of surgery of the parotid gland. Ann R Coll Surg Engl 77(3):188–192
Marchese-Ragona R, De Filippis C, Marioni G, Staffieri A (2005) Treatment of complications of parotid gland surgery. Acta Otorhinolaryngol Ital 25(3):174–178
Cillero Ruiz G, Espinosa Sánchez JM, Ruiz de Erenchun Lasa I, Alcalde Navarrete J, García-Tapia Urrutia R (1994) Intraoperative facial nerve monitoring: results. Acta Otorrinolaringol Esp 45(6):425–431
Terrell JE, Kileny PR, Yian C et al (1997) Clinical outcome of continuous facial nerve monitoring during primary parotidectomy. Arch Otolaryngol Head Neck Surg 123(10):1081–1087
Witt RL (1998) Facial nerve monitoring in parotid surgery: the standard of care? Otolaryngol Head Neck Surg 119(5):468–470
Deneuve S, Quesnel S, Depondt J et al (2010) Management of parotid gland surgery in a university teaching hospital. Eur Arch Otorhinolaryngol 267(4):601–605
Pons Y, Clément P, Crambert A, Conessa C (2010) Facial nerve monitoring in the parotidectomy. Rev Laryngol Otol Rhinol (Bord) 131(4–5):253–256
Régloix SB, Grinholtz-Haddad J, Maurin O, Genestier L, Lisan Q, Pons Y (2016) Facial nerve monitoring during parotidectomy: a two-center retrospective study. Iran J Otorhinolaryngol 28(87):255–260
Woods JE, Chong GC, Beahrs OH (1975) Experience with 1,360 primary parotid tumors. Am J Surg 130(4):460–462
Grosheva M, Klussmann JP, Grimminger C et al (2009) Electromyographic facial nerve monitoring during parotidectomy for benign lesions does not improve the outcome of postoperative facial nerve function: a prospective two-center trial. Laryngoscope 119(12):2299–2305
López M, Quer M, León X, Orús C, Recher K, Vergés J (2001) Usefulness of facial nerve monitoring during parotidectomy. Acta Otorrinolaringol Esp 52(5):418–421
Savvas E, Hillmann S, Weiss D, Koopmann M, Rudack C, Alberty J (2016) Association between facial nerve monitoring with postoperative facial paralysis in parotidectomy. JAMA Otolaryngol Head Neck Surg 142(9):828–833
Gonzalez-Cardero E, Infante-Cossio P, Cayuela A, Acosta-Feria M, Gutierrez-Perez JL (2012) Facial disability index (FDI): adaptation to Spanish, reliability and validity. Med Oral Patol Oral Cir Bucal 17(6):e1006–e1012
Prats-Golczer VE, Gonzalez-Cardero E, Exposito-Tirado JA, Montes-Latorre E, Gonzalez-Perez LM, Infante-Cossio P (2017) Impact of dysfunction of the facial nerve after superficial parotidectomy: a prospective study. Br J Oral Maxillofac Surg 55(8):798–802
Bron LP, O’Brien CJ (1997) Facial nerve function after parotidectomy. Arch Otolaryngol Head Neck Surg 123(10):1091–1096
Gaillard C, Périé S, Susini B, St Guily JL (2005) Facial nerve dysfunction after parotidectomy: the role of local factors. Laryngoscope 115(2):287–291
Sethi N, Tay PH, Scally A, Sood S (2014) Stratifying the risk of facial nerve palsy after benign parotid surgery. J Laryngol Otol 128(2):159–162
Ikoma R, Ishitoya J, Sakuma Y, Hirama M, Shiono O, Komatsu M, Oridate N (2014) Temporary facial nerve dysfunction after parotidectomy correlates with tumor location. Auris Nasus Larynx 41(5):479–484
Fattah AY, Gavilan J, Hadlock TA et al (2014) Survey of methods of facial palsy documentation in use by members of the Sir Charles Bell Society. Laryngoscope 124:2247–2251
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Written informed consent was obtained from all individual participants included in the study.
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Graciano, A.J., Fischer, C.A., Coelho, G.V. et al. Facial nerve dysfunction after superficial parotidectomy with or without continuous intraoperative electromyographic neuromonitoring: a prospective randomized pilot study. Eur Arch Otorhinolaryngol 275, 2861–2868 (2018). https://doi.org/10.1007/s00405-018-5130-1
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DOI: https://doi.org/10.1007/s00405-018-5130-1