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Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics

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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Background

The incidence of thyroid cancer is fast increasing in both adults and children. The pediatric thyroid cancer had often already progressed to a more advanced stage of the disease at diagnosis. Early detection of pediatric thyroid cancer has been a problem for many years. Lipocalin-2 (Lcn2) has been reported to be over-expressed in cancers of diverse histological origin and it facilitates tumorigenesis by promoting survival, growth, and metastasis.

Methods

The plasma Lcn2 concentration of 28 Chinese papillary thyroid cancer (PTC) children and 24 healthy controls was measured. Immunostaining for Ki-67 of tumor tissue from PTC children was performed. The expression levels of Lcn2 and NFκB in PTC tissue and peri-carcinoma tissue of PTC children were measured through Western blot.

Results

The plasma concentration of Lcn2 was significantly elevated in pediatric PTC patients compared with healthy controls. Besides, the plasma Lcn2 concentration significantly correlated with clinical characteristics, NFκB level, and Ki-67 positive rate of nucleus in tissue of PTC.

Conclusion

This is the first study to evaluate the plasma Lcn2 in pediatric PTC patients. It is possible that the plasma Lcn2 may be a new biomarker of pediatric thyroid cancer. Further studies are needed to explore the definite role and mechanism of Lcn2 in thyroid cancer, which will help to explore novel diagnostic or therapeutic strategies.

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Acknowledgements

We thank the otorhinolaryngology—head and neck surgery department of Beijing Children’s Hospital for providing human laryngeal tissue samples.

Funding

This work was supported by Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding (ZYLX201508) and Beijing Municipal Science and Technology Project (Z151100003715006).

Author information

Author notes

  1. Jun Tai and Shengcai Wang have contributed equally to this work.

Authors and Affiliations

  1. Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China

    Jun Tai, Shengcai Wang, Jie Zhang, Wentong Ge, Yuanhu Liu, Xiaodan Li, Yuwei Liu, Zhijuan Deng, Lejian He, Guoliang Wang & Xin Ni

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, No. 56 Nanlishi Road, Beijing, 100045, China

    Jun Tai, Shengcai Wang, Jie Zhang, Wentong Ge, Yuanhu Liu, Xiaodan Li, Yuwei Liu & Xin Ni

  3. Department of Pathology, Beijing Children’s Hospital, Capital Medical University, Beijing, China

    Zhijuan Deng & Lejian He

Authors
  1. Jun Tai
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  2. Shengcai Wang
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  8. Zhijuan Deng
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  10. Guoliang Wang
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  11. Xin Ni
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Corresponding authors

Correspondence to Guoliang Wang or Xin Ni.

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The authors declare that there are no conflicts of interest.

Ethical approval

The ethnics were approved by Beijing Children’s Hospital Ethics Committee. All human subjects or their parents (or legal guardians) had provided written informed consent.

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Cite this article

Tai, J., Wang, S., Zhang, J. et al. Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics. Eur Arch Otorhinolaryngol 275, 2823–2828 (2018). https://doi.org/10.1007/s00405-018-5118-x

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  • DOI: https://doi.org/10.1007/s00405-018-5118-x

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