Abstract
Purpose
To assess the ultrasonographic features affect accuracy of extrathyroid extension (ETE) evaluation on preoperative ultrasonography (US) in papillary thyroid microcarcinoma (PTMC).
Methods
Of the total patients who underwent thyroid surgery, 516 patients with a tumor measuring less than 1 cm on preoperative US were enrolled in this study. One blinded head and neck radiologist reviewed the preoperative US images to evaluate the US features of PTMC, and the pathologic reports were reviewed. The diagnostic accuracy rates, including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, were calculated, and the factors associated with false-negative and false-positive results for ETE were analyzed.
Results
The sensitivity, specificity, PPV, NPV, and accuracy for predicting ETE according to sonographic criteria were 32.8%, 87.5%, 51.0%, 76.6%, and 71.7%, respectively. Non-adjacent to the trachea and unilateral lesion on US were significant factors associated with false-negative results.
Conclusion
Size, shape, and location of PTMC on US are important factors that affect the US results in ETE evaluation.
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Acknowledgements
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP) (NRF-2017R1C1B5017244), by a Grant from Kyung Hee University in 2018(KHU- 20181063), the Bio and Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIP&MOHW) and by a Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant no: HI18C1039).
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YCL, study design, data collection and analysis, writing; ARJ, study design, data collection, analysis and revising article; Y-MS, study design, data collection, analysis and revising article; E-JK, study design, data collection, analysis and revising article; Y-GE, study design, data collection and analysis, revising article, and supervising this study.
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Lee, Y.C., Jung, A.R., Sohn, YM. et al. Ultrasonographic features associated with false-negative and false-positive results of extrathyroidal extensions in papillary thyroid microcarcinoma. Eur Arch Otorhinolaryngol 275, 2817–2822 (2018). https://doi.org/10.1007/s00405-018-5115-0
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DOI: https://doi.org/10.1007/s00405-018-5115-0