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European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 11, pp 2643–2652 | Cite as

3D fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging at different stages of otosclerosis

  • Stefano BerrettiniEmail author
  • Francesco Lombardo
  • Luca Bruschini
  • Annalisa Ciabotti
  • Canapicchi Raffaello
  • De Cori Sara
  • De Marchi Daniele
  • Francesca Forli
Otology
  • 97 Downloads

Abstract

Purpose

The aim of this work is to study otosclerotic patients by 3D-FLAIR (fluid attenuated inversion recovery) sequence magnetic resonance imaging (MRI) with and without Gadolinium administration (−/+ Gd), to understand whether there is a direct relationship between radiological findings at 3D FLAIR MRI sequences and some clinical features of otosclerosis, such as the presence and entity of sensorineural involvement, duration of disease, patient gender, and other factors.

Methods

38 patients affected by different stages of unilateral or bilateral otosclerosis underwent 3D FLAIR MRI+/− Gd. 11 subjects with normal hearing, previously submitted to 3T MRI for other minor diseases, unrelated with otosclerosis, had been retrospectively enrolled as control group.

Results

We found significant correlations between 3D FLAIR MRI findings and some clinical features of otosclerosis, such as severity of cochlear damage (in terms of entity of sensorineural loss) and duration of disease. These findings indicate that at 3D-FLAIR MRI different patterns may depend on the level of blood labyrinth barrier damage in the cochlea, and be related to different stages of cochlear involvement in otosclerotic patients.

Conclusions

We believe that our findings may contribute in understanding the pathogenesis of cochlear damage in otosclerosis and may have further prognostic value. Our results led us to consider the possible use of 3D-FLAIR sequences in monitoring the effectiveness of any medical therapy of otosclerosis and in selecting the patients eligible for treatment.

Keywords

Otosclerosis Sensorineural hearing loss MRI 3D-FLAIR 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

For this type of study formal consent is not required. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Berrettini S, Ravecca F, Volterrani D, Neri E, Forli F (2010) Imaging evaluation in otosclerosis: single photon emission computed tomography and computed tomography. Ann Otol Rhinol Laryngol 119(4):215–224CrossRefGoogle Scholar
  2. 2.
    Berrettini S, Seccia V, Fortunato S et al (2013) Analysis of the 3-dimensional fluid-attenuated inversion-recovery (3D-FLAIR) sequence in idiopathic sudden sensorineural hearing loss. JAMA Otolaryngol Head Neck Surg 139(5):456–464CrossRefGoogle Scholar
  3. 3.
    Canapicchi R, De Marchi D, Lombardo F, Fortunato S, De Cori S, Montanaro D, Berrettini S (2010) Sudden sensorineural hearing loss. MR Imaging Neuroradiol J 23(2):161–171CrossRefGoogle Scholar
  4. 4.
    de Oliveira Vicente A, Chandrasekhar SS, Yamashita HK, Cruz OL, Barros FA, Penido NO (2015) Magnetic resonance imaging in the evaluation of clinical treatment of otospongiosis: a pilot study. Otolaryngol Head Neck Surg 152(6):1119–1126CrossRefGoogle Scholar
  5. 5.
    Floc’h JL, Tan W, Telang RS, Vlajkovic SM, Nuttall A, Rooney WD, Pontré B, Thorne PR (2014) Markers of cochlear inflammation using MRI. J Magn Reson Imaging 39(1):150–161CrossRefGoogle Scholar
  6. 6.
    Goh JP, Chan LL, Tan TY (2002) MRI of cochlear otosclerosis. Br J Radiol 75(894):502–505CrossRefGoogle Scholar
  7. 7.
    Lee TC, Aviv RI, Chen JM, Nedzelski JM, Fox AJ, Symons SP (2009) CT grading of otosclerosis. AJNR Am J Neuroradiol 30(7):1435–1439CrossRefGoogle Scholar
  8. 8.
    Lolov SR, Encheva VI, Kyurkchiev SD, Edrev GE, Kehayov IR (2001) Antimeasles immunoglobulin G in sera of patients with otosclerosis is lower than that in healthy people. Otol Neurotol 22(6):766–770CrossRefGoogle Scholar
  9. 9.
    Lombardo F, De Cori S, Aghakhanyan G et al (2016) 3D-Flair sequence at 3T in cochlear otosclerosis. Eur Radiol 26(10):3744–3751CrossRefGoogle Scholar
  10. 10.
    Markou K, Goudakos J (2009) An overview of the etiology of otosclerosis. Eur Arch Otol Rhinol Laryngol 266(1):25–35CrossRefGoogle Scholar
  11. 11.
    Naganawa S, Kawai H, Taoka T, Suzuki K, Iwano S, Satake H, Sone M, Ikeda M (2016) Cochlear lymph fluid signal increase in patients with otosclerosis after intravenous administration of gadodiamide. Magn Reson Med Sci 15(3):308–315CrossRefGoogle Scholar
  12. 12.
    Stankovic KM, McKenna MJ (2006) Current research in otosclerosis. Curr Opin Otolaryngol Head Neck Surg 14(5):347–351CrossRefGoogle Scholar
  13. 13.
    Sugiura M, Naganawa S, Sone M, Yoshida T, Nakashima T (2008) Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in a patient with cochlear otosclerosis. Auris Nasus Larynx 35(2):269–272CrossRefGoogle Scholar
  14. 14.
    Sugiura M, Naganawa S, Teranishi M, Nakashima T (2006) Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in patients with sudden sensorineural hearing loss. Laryngoscope 116(8):1451–1454CrossRefGoogle Scholar
  15. 15.
    Swartz JD, Mandell DW, Berman SE, Wolfson RJ, Marlowe FI, Popky GL (1985) Cochlear otosclerosis (otospongiosis): CT analysis with audiometric correlation. Radiology 155:147–150CrossRefGoogle Scholar
  16. 16.
    Swartz JD, Mandell DW, Wolfson RJ et al (1985) Fenestral and cochlear otosclerosis: computed tomographic evaluation. Am J Otol 6:476–481PubMedGoogle Scholar
  17. 17.
    Valvassori GE (1993) Imaging of otosclerosis. Otorinolaryngol Clin N Am 26(3):359–371Google Scholar
  18. 18.
    Virk JS, Singh A, Lingam RK (2013) The role of imaging in the diagnosis and management of otosclerosis. Otol Neurotol 34(7):55–60CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.ENT Audiology and Phoniatrics Unit, Department of Surgical, Medical, Molecular Pathology and Emergency MedicineUniversity of PisaPisaItaly
  2. 2.Division of ENT DiseasesKarolinska InstitutetStockholmSweden
  3. 3.Neuroradiology UnitFondazione CNR Regione Toscana “G. Monasterio”PisaItaly

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