European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 6, pp 1477–1482 | Cite as

Impact of odontogenic chronic rhinosinusitis on general health-related quality of life

  • Robert A. Gaudin
  • Lloyd P. Hoehle
  • Ralf Smeets
  • Max Heiland
  • David S. Caradonna
  • Stacey T. Gray
  • Ahmad R. Sedaghat


Chronic rhinosinusitis (CRS) may arise due to odontogenic etiologies. However, it is unknown whether odontogenic CRS has a differential impact on patients’ quality of life (QOL) compared to standard, inflammatory (but non-odontogenic) CRS. The objective of this study was to determine whether there is a difference in the impact of sinonasal symptomatology on general health-related QOL in odontogenic CRS compared to non-odontogenic CRS. This was a retrospective review of 21 odontogenic CRS patients who visited our tertiary care center. The severity of sinonasal symptomatology and CRS-specific QOL detriment was measured using the 22-item Sinonasal Outcomes Test (SNOT-22) and general health-related QOL was measured using the health utility index from the 5-item EuroQol survey (EQ-5D HUV). Compared to non-odontogenic CRS, odontogenic CRS was not associated with a difference in SNOT-22 score [linear regression coefficient (β) = − 1.57, 95% CI − 12.47 to 9.32, p = 0.777] but was significantly associated with decreased EQ-5D HUV (β = − 0.10, 95% CI − 0.17 to − 0.03, p = 0.008). We also found that the magnitude of association (β) between SNOT-22 and EQ5D-HUV was greater for odontogenic CRS patients compared to non-odontogenic CRS patients (p = 0.045). Our findings suggest sinonasal symptoms may have a greater impact on general QOL in odontogenic CRS compared to non-odontogenic CRS. The reason for this remains unknown, but deserves further study.


Chronic rhinosinusitis Odontogenic sinusitis Non-odontogenic sinusitis SNOT-22 EQ-5D HUV Quality of life 



The authors gratefully acknowledge the contribution of the patients who participated in this study.



Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Robert A. Gaudin
    • 1
  • Lloyd P. Hoehle
    • 2
    • 3
  • Ralf Smeets
    • 4
  • Max Heiland
    • 1
  • David S. Caradonna
    • 2
    • 5
  • Stacey T. Gray
    • 2
    • 3
  • Ahmad R. Sedaghat
    • 2
    • 3
    • 5
    • 6
  1. 1.Klinik für Mund- Kiefer- und GesichtschirurgieUniversitätsmedizin Charité BerlinBerlinGermany
  2. 2.Department of OtolaryngologyHarvard Medical SchoolBostonUSA
  3. 3.Department of OtolaryngologyMassachusetts Eye and Ear InfirmaryBostonUSA
  4. 4.Klinik für Mund- Kiefer- und GesichtschirurgieUniversitätsklinikum, Hamburg EppendorfHamburgGermany
  5. 5.Division OtolaryngologyBeth Israel Deaconness Medical CenterBostonUSA
  6. 6.Department of Otolaryngology and Communications EnhancementBoston Children’s HospitalBostonUSA

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