Chronic rhinosinusitis (CRS) may arise due to odontogenic etiologies. However, it is unknown whether odontogenic CRS has a differential impact on patients’ quality of life (QOL) compared to standard, inflammatory (but non-odontogenic) CRS. The objective of this study was to determine whether there is a difference in the impact of sinonasal symptomatology on general health-related QOL in odontogenic CRS compared to non-odontogenic CRS. This was a retrospective review of 21 odontogenic CRS patients who visited our tertiary care center. The severity of sinonasal symptomatology and CRS-specific QOL detriment was measured using the 22-item Sinonasal Outcomes Test (SNOT-22) and general health-related QOL was measured using the health utility index from the 5-item EuroQol survey (EQ-5D HUV). Compared to non-odontogenic CRS, odontogenic CRS was not associated with a difference in SNOT-22 score [linear regression coefficient (β) = − 1.57, 95% CI − 12.47 to 9.32, p = 0.777] but was significantly associated with decreased EQ-5D HUV (β = − 0.10, 95% CI − 0.17 to − 0.03, p = 0.008). We also found that the magnitude of association (β) between SNOT-22 and EQ5D-HUV was greater for odontogenic CRS patients compared to non-odontogenic CRS patients (p = 0.045). Our findings suggest sinonasal symptoms may have a greater impact on general QOL in odontogenic CRS compared to non-odontogenic CRS. The reason for this remains unknown, but deserves further study.
Chronic rhinosinusitis Odontogenic sinusitis Non-odontogenic sinusitis SNOT-22 EQ-5D HUV Quality of life
This is a preview of subscription content, log in to check access.
The authors gratefully acknowledge the contribution of the patients who participated in this study.
Compliance with ethical standards
Conflict of interest
The authors declare that there are no conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
Zirk M, Dreiseidler T, Pohl M et al (2017) Odontogenic sinusitis maxillaris: a retrospective study of 121 cases with surgical intervention. J Craniomaxillofac Surg 45(4):520–525CrossRefPubMedGoogle Scholar
Hoehle LP, Phillips KM, Bergmark RW et al (2016) Symptoms of chronic rhinosinusitis differentially impact general health-related quality of life. Rhinology 54(4):316–322PubMedCrossRefGoogle Scholar
Phillips KM, Hoehle LP, Bergmark RW et al (2017) Acute exacerbations mediate quality of life impairment in chronic rhinosinusitis. J Allergy Clin Immunol Pract 5(2):422–426CrossRefPubMedGoogle Scholar
Phillips KM, Hoehle LP, Caradonna DS et al (2016) Association of severity of chronic rhinosinusitis with degree of comorbid asthma control. Ann Allergy Asthma Immunol 117(6):651–654CrossRefPubMedGoogle Scholar
Sedaghat AR, Gray ST, Wilke CO et al (2012) Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis. Int Forum Allergy Rhinol 2(5):370–375CrossRefPubMedGoogle Scholar
Sedaghat AR, Phipatanakul W, Cunningham MJ (2013) Atopy and the development of chronic rhinosinusitis in children with allergic rhinitis. J Allergy Clin Immunol Pract 1(6):689–691CrossRefPubMedGoogle Scholar
Lopez-Carriches C, Lopez-Carriches I, Bryan RB (2016) Odontogenic sinusitis caused by an inflammation of a dentigerous cyst and subsequent finding of a fibrous dysplasia. A case report. Open Dent J 10:647–655CrossRefPubMedPubMedCentralGoogle Scholar
McCarty JL, David RM, Lensing SY et al (2017) Root cause analysis: an examination of odontogenic origins of acute maxillary sinusitis in both immunocompetent & immunocompromised patients. J Comput Assist Tomogr 41(3):484–488CrossRefPubMedGoogle Scholar
Bewick J, Morris S, Hopkins C et al (2018) Health utility reporting in chronic rhinosinusitis patients. Clin Otolaryngol 43(1):90–95CrossRefPubMedGoogle Scholar
Guilemany JM, Angrill J, Alobid I et al (2009) United airways: the impact of chronic rhinosinusitis and nasal polyps in bronchiectasic patient’s quality of life. Allergy 64(10):1524–1529CrossRefPubMedGoogle Scholar
Remenschneider AK, D’Amico L, Gray ST et al (2015) The EQ-5D: a new tool for studying clinical outcomes in chronic rhinosinusitis. Laryngoscope 125(1):7–15CrossRefPubMedGoogle Scholar