Advertisement

European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 6, pp 1365–1373 | Cite as

Highlights from the Second International Symposium on HPV infection in head and neck cancer

  • Susanne Wiegand
  • G. Wichmann
  • W. Golusinski
  • C. R. Leemans
  • J. P. Klussmann
  • A. Dietz
Review Article

Abstract

The Second International Symposium on HPV Infection in Head and Neck Cancer was held on 3rd–4th November 2016 in Leipzig, Germany. The meeting brought together researchers and clinicians to share the latest knowledge on HPV infection in head and neck cancer and to join active and constructive scientific discussions. This report summarizes the major themes discussed during the symposium.

Keywords

HPV Oropharynx Head neck cancer 

Notes

Compliance with ethical standards

Conflict of interest

G. Wichmann, W. Golusinski, C.R. Leemans and J.P. Klussmann declare that there is no conflict of interest. S. Wiegand: Remuneration for scientific presentations and participation on Advisory Boards: Bristol-Myers Squibb, Merck Serono, Astra Zeneca A. Dietz: Remuneration for scientific presentations and participation on Advisory Boards: Merck Serono, Roche, Astra Zeneca, MSD, BMS; Research Support: Roche, Merck Serono.

Ethical approval.

This article does not contain any studies with human participants or animals.

References

  1. 1.
    Syrjanen K, Syrjanen S, Lamberg M, Pyrhonen S, Nuutinen J (1983) Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. Int J Oral Surg 12:418–424CrossRefPubMedGoogle Scholar
  2. 2.
    Lim MY, Dahlstrom KR, Sturgis EM, Li G (2016) Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma. Head Neck 38:1139–1144CrossRefPubMedGoogle Scholar
  3. 3.
    Vojtechova Z, Sabol I, Salakova M, Turek L, Grega M, Smahelova J, Vencalek O, Lukesova E, Klozar J, Tachezy R (2016) Analysis of the integration of human papillomaviruses in head and neck tumours in relation to patients’ prognosis. Int J Cancer 138:386–395CrossRefPubMedGoogle Scholar
  4. 4.
    Faust H, Eldenhed Alwan E, Roslin A, Wennerberg J, Forslund O (2016) Prevalence of human papillomavirus types, viral load and physical status of HPV16 in head and neck squamous cell carcinoma from the South Swedish Health Care Region. J Gen Virol 97:2949–2956CrossRefPubMedGoogle Scholar
  5. 5.
    Reuschenbach M, Pauligk C, Karbach J, Rafiyan MR, Kloor M, Prigge ES, Sauer M, Al-Batran SE, Kaufmann AM, Schneider A, Jäger E, von Knebel Doeberitz M (2016) A phase 1/2a study to test the safety and immunogenicity of a p16(INK4a) peptide vaccine in patients with advanced human papillomavirus-associated cancers. Cancer 122:1425–1433CrossRefPubMedGoogle Scholar
  6. 6.
    Herrero R, Castellsagué X, Pawlita M, Lissowska J, Kee F, Balaram P, Rajkumar T, Sridhar H, Rose B, Pintos J, Fernández L, Idris A, Sánchez MJ, Nieto A, Talamini R, Tavani A, Bosch FX, Reidel U, Snijders PJ, Meijer CJ, Viscidi R, Muñoz N, Franceschi S, IARC Multicenter Oral Cancer Study Group (2003) Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 95:1772–1783CrossRefPubMedGoogle Scholar
  7. 7.
    Kreimer AR, Johansson M, Waterboer T, Kaaks R, Chang-Claude J, Drogen D, Tjønneland A, Overvad K, Quirós JR, González CA, Sánchez MJ, Larrañaga N, Navarro C, Barricarte A, Travis RC, Khaw KT, Wareham N, Trichopoulou A, Lagiou P, Trichopoulos D, Peeters PH, Panico S, Masala G, Grioni S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Laurell G, Hallmans G, Manjer J, Ekström J, Skeie G, Lund E, Weiderpass E, Ferrari P, Byrnes G, Romieu I, Riboli E, Hildesheim A, Boeing H, Pawlita M, Brennan P (2013) Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol 31:2708–2715CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Anantharaman D, Gheit T, Waterboer T, Abedi-Ardekani B, Carreira C, McKay-Chopin S, Gaborieau V, Marron M, Lagiou P, Ahrens W, Holcátová I, Merletti F, Kjaerheim K, Talamini R, Simonato L, Castellsague X, Macfarlane TV, Biggs AM, Thakker N, Znaor A, Thomson P, Canova C, Conway DI, Healy CM, Tommasino M, Pawlita M, Brennan P (2013) Human papillomavirus infections and upper aero-digestive tract cancers: the ARCAGE study. J Natl Cancer Inst 105:536–545CrossRefPubMedGoogle Scholar
  9. 9.
    Leemans CR, Braakhuis BJ, Brakenhoff RH (2011) The molecular biology of head and neck cancer. Nat Rev Cancer 11:9–22CrossRefPubMedGoogle Scholar
  10. 10.
    Lawrence MS, Sougnez C, Lichtenstein L et al (2015) Cancer Genome Atlas Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517:576–582CrossRefGoogle Scholar
  11. 11.
    Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, Rapozo D, Long A, Cubie H, Junor E, Monaghan H, Harrington KJ, Nutting CM, Schick U, Lau AS, Upile N, Sheard J, Brougham K, West CM, Oguejiofor K, Thomas S, Ness AR, Pring M, Thomas GJ, King EV, McCance DJ, James JA, Moran M, Sloan P, Shaw RJ, Evans M, Jones TM (2016) HPV-related oropharynx cancer in the United Kingdom: an evolution in the understanding of disease etiology. Cancer Res 76:6598–6606CrossRefPubMedGoogle Scholar
  12. 12.
    Huang SH, Xu W, Waldron J, Siu L, Shen X, Tong L, Ringash J, Bayley A, Kim J, Hope A, Cho J, Giuliani M, Hansen A, Irish J, Gilbert R, Gullane P, Perez-Ordonez B, Weinreb I, Liu FF, O’Sullivan B (2015) Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas. J Clin Oncol 33:836–845CrossRefPubMedGoogle Scholar
  13. 13.
    Dahlstrom KR, Garden AS, William WN Jr, Lim MY, Sturgis EM (2016) Proposed staging system for patients With HPV-related oropharyngeal cancer based on nasopharyngeal cancer N categories. J Clin Oncol 34:1848–1854CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Jayaram SC, Muzaffar SJ, Ahmed I, Dhanda J, Paleri V, Mehanna H (2016) Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: a systematic review and meta-analysis. Head Neck 38:1855–1861CrossRefPubMedGoogle Scholar
  15. 15.
    Leijenaar RT, Carvalho S, Hoebers FJ, Aerts HJ, van Elmpt WJ, Huang SH, Chan B, Waldron JN, O’sullivan B, Lambin P (2015) External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma. Acta Oncol 54:1423–1429CrossRefPubMedGoogle Scholar
  16. 16.
    Fischer M, Quaas M, Wintsche A, Müller GA, Engeland K (2014) Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein. Nucleic Acids Res 42:163–180CrossRefPubMedGoogle Scholar
  17. 17.
    Wichmann G, Rosolowski M, Krohn K, Kreuz M, Boehm A, Reiche A, Scharrer U, Halama D, Bertolini J, Bauer U, Holzinger D, Pawlita M, Hess J, Engel C, Hasenclever D, Scholz M, Ahnert P, Kirsten H, Hemprich A, Wittekind C, Herbarth O, Horn F, Dietz A, Loeffler M, Leipzig Head and Neck Group (LHNG) (2015) The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer. Int J Cancer 137:2846–2857CrossRefPubMedGoogle Scholar
  18. 18.
    Jiang N, Zhang LJ, Li LY, Zhao Y, Eisele DW (2016) Risk factors for late dysphagia after (chemo)radiotherapy for head and neck cancer: a systematic methodological review. Head Neck 38:792–800CrossRefPubMedGoogle Scholar
  19. 19.
    Christianen ME, Verdonck-de Leeuw IM, Doornaert P, Chouvalova O, Steenbakkers RJ, Koken PW, Leemans CR, Oosting SF, Roodenburg JL, van der Laan BF, Slotman BJ, Bijl HP, Langendijk JA (2015) Patterns of long-term swallowing dysfunction after definitive radiotherapy or chemoradiation. Radiother Oncol 117:139–144CrossRefPubMedGoogle Scholar
  20. 20.
    Brouwer CL, Steenbakkers RJ, Bourhis J, Budach W, Grau C, Grégoire V, van Herk M, Lee A, Maingon P, Nutting C, O’Sullivan B, Porceddu SV, Rosenthal DI, Sijtsema NM, Langendijk JA (2015) CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines. Radiother Oncol 117:83–90CrossRefPubMedGoogle Scholar
  21. 21.
    Brotherston DC, Poon I, Le T, Leung M, Kiss A, Ringash J, Balogh J, Lee J, Wright JR (2013) Patient preferences for oropharyngeal cancer treatment de-escalation. Head Neck 35:151–159CrossRefPubMedGoogle Scholar
  22. 22.
    Sinha P, Kallogjeri D, Gay H, Thorstad WL, Lewis JS Jr, Chernock R, Nussenbaum B, Haughey BH (2015) High metastatic node number, not extracapsular spread or N-classification is a node-related prognosticator in transorally-resected, neck-dissected p16-positive oropharynx cancer. Oral Oncol 51:514–520CrossRefPubMedGoogle Scholar
  23. 23.
    Sinha P, Lewis JS Jr, Piccirillo JF, Kallogjeri D, Haughey BH (2012) Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. Cancer 118:3519–3530CrossRefPubMedGoogle Scholar
  24. 24.
    O’Sullivan B, Huang SH, Su J, Garden AS, Sturgis EM, Dahlstrom K, Lee N, Riaz N, Pei X, Koyfman SA, Adelstein D, Burkey BB, Friborg J, Kristensen CA, Gothelf AB, Hoebers F, Kremer B, Speel EJ, Bowles DW, Raben D, Karam SD, Yu E, Xu W (2016) Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): a multicentre cohort study. Lancet Oncol 17:440–451CrossRefPubMedGoogle Scholar
  25. 25.
    Mehanna H, Wong WL, McConkey CC, Rahman JK, Robinson M, Hartley AG, Nutting C, Powell N, Al-Booz H, Robinson M, Junor E, Rizwanullah M, von Zeidler SV, Wieshmann H, Hulme C, Smith AF, Hall P, Dunn J, PET-NECK Trial Management Group (2016) PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer. N Engl J Med 374:1444–1454CrossRefPubMedGoogle Scholar
  26. 26.
    European Medicines Agency (2015) Summary of opinion: gardasil 9 human papillomavirus 9-valent vaccine (recombinant, adsorbed). http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/003852/WC500184904.pdf. (26-3-2015. 25-9-2015)
  27. 27.
    Wagner S, Wittekindt C, Reuschenbach M, Hennig B, Thevarajah M, Würdemann N, Prigge ES, von Knebel Doeberitz M, Dreyer T, Gattenlöhner S, Klussmann JP (2016) CD56-positive lymphocyte infiltration in relation to human papillomavirus association and prognostic significance in oropharyngeal squamous cell carcinoma. Int J Cancer 138:2263–2273CrossRefPubMedGoogle Scholar
  28. 28.
    Ahn SM, Chan JY, Zhang Z, Wang H, Khan Z, Bishop JA, Westra W, Koch WM, Califano JA (2014) Saliva and plasma quantitative polymerase chain reaction-based detection and surveillance of human papillomavirus-related head and neck cancer. JAMA Otolaryngol Head Neck Surg 140:846–854CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Braig F, Voigtlaender M, Schieferdecker A, Busch CJ, Laban S, Grob T, Kriegs M, Knecht R, Bokemeyer C, Binder M (2016) Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma. Oncotarget 7:42988–42995CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Guerrero-Preston R, Godoy-Vitorino F, Jedlicka A, Rodríguez-Hilario A, González H, Bondy J, Lawson F, Folawiyo O, Michailidi C, Dziedzic A, Thangavel R, Hadar T, Noordhuis MG, Westra W, Koch W, Sidransky D (2016) 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget 7:51320–51334CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otolaryngology, Head and Neck SurgeryUniversity of LeipzigLeipzigGermany
  2. 2.Department of Head and Neck Surgery, Greater Poland Cancer CentrePoznan University of Medical SciencesPoznańPoland
  3. 3.Department of Otolaryngology Head and Neck SurgeryVU University Medical CenterAmsterdamThe Netherlands
  4. 4.Department of Otorhinolaryngology, Head and Neck SurgeryUniversity of GiessenGiessenGermany

Personalised recommendations