European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 6, pp 1601–1606 | Cite as

Organ preservation surgery for patients with T4a laryngeal cancer

  • Caiyun Zhang
  • Minhui Zhu
  • Donghui Chen
  • Shicai Chen
  • Hongliang Zheng
Head and Neck



Surgical preservation of laryngeal function is very challenging in patients with advanced SCCL, especially those of stage T4a. The purpose of this study was to assess the feasibility of organ preservation surgery for patients with T4a squamous cell carcinoma of the larynx (SCCL).


We enrolled 32 patients with T4a SCCL and performed organ preservation surgery on them. Surgical details and perioperative morbidity were described, functional and oncologic outcomes were also evaluated.


All patients underwent supracricoid subtotal laryngectomy with unilateral or bilateral neck dissection, restoring laryngeal function via direct anastomosis of the cricoid cartilage and tongue base. The patients recovered well and exhibited relatively acceptable survival duration, with a 5-year overall survival rate of 62.5%. Most patients commenced oral intake within 2 weeks, and aspiration was commonly observed. Subjective functional outcomes indicated a relatively acceptable swallowing function and voice quality.


Our retrospective analysis of 32 patients with T4a SCCL showed that successful organ preservation surgery is safe and reliable, and associated with a relatively acceptable disease-free survival, normal swallowing function, and acceptable voice quality. More patients with T4a SCCL who wish to preserve the larynx should be considered for organ preservation surgery.


T4a laryngeal cancer Organ preservation Total laryngectomy Chemoradiation 



This work was supported by a grant from the National Natural Science Foundation of China (No. 81502361).

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

The study was approved the ethical standards of the institutional research committee and conducted in accordance to the principles of the Declaration of Helsinki (1964).

Informed consent

General informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology-Head and Neck Surgery, Changhai HospitalSecond Military Medical UniversityShanghaiChina

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