European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 5, pp 1265–1270 | Cite as

Bupivacaine wound infiltration reduces postoperative pain and analgesic requirement after thyroid surgery

  • Moncef Sellami
  • Sarhan Feki
  • Zied Triki
  • Jamil Zghal
  • Imen Zouche
  • Boutheina Hammami
  • Ilhem Charfeddine
  • Mohamed Chaari
  • Abdelmonem Ghorbel
Head and Neck


Background and objective

We conducted a prospective double-blind randomized study assessing bupivacaine end-of-surgery wound infiltration for pain relief in thyroid surgery.


Patients were randomly divided into two groups: Group S, local wound infiltration with saline solution; Group B, bupivacaine 0.5% was administered. Pain perception was measured using visual analogue scale (VAS) during post-anaesthetic care unit (PACU) stay every 10 min and during the 24 postoperative hours admission at 2, 4, 6, 12, and 24 h after surgery. The total consumption of analgesics (morphine and nefopam) was recorded.


Sixty patients were studied. The VAS scores were significantly lower in the bupivacaine administered group in the post-anaesthetic care unit (PACU) at 0, 10, 20, 30, 40, 50 and 60 min, and during the hospital stay at hours 6, 12, 18 and 24. The number of patients who required postoperative opioid rescue was significantly lower in group B. No patient in group B developed neurological or cardiological complications after infiltration.


Bupivacaine application is effective in decreasing postoperative pain and analgesic requirement during the hospital stay for patients with thyroidectomy.


Bupivacaine Pain Analgesia Thyroidectomy 


Compliance with ethical standards

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Research involving human participants and/or animals

The study was approved by the appropriate institutional ethics committee and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Head and Neck SurgeryHabib Bourguiba University HospitalSfaxTunisia
  2. 2.Department of AnesthesiaHabib Bourguiba University HospitalSfaxTunisia

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