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An essential dose of cisplatin for super-selective intra-arterial infusion concomitant with radiotherapy in patient with maxillary squamous cell carcinoma

  • Head and Neck
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Abstract

The present study investigated the efficacy and safety of using a lower dose of cisplatin (CDDP) in super-selective intra-arterial concurrent chemoradiotherapy (SSIACRT) to treat maxillary squamous cell carcinoma. 10 patients with maxillary squamous cell carcinoma (T3 n = 6, T4a n = 4) without regional or distant metastasis were treated by SSIACRT. The CDDP dose per course was 100 mg/body, i.e. 50–80 mg/m2. 6–9 weeks after SSIACRT, partial maxillectomy was performed on all patients. Clinical and histological responses, survival rates, and adverse events were investigated. 10 (100%) of 10 patients achieved both clinical and pathological complete or partial remission. The 3-year overall and disease-free survival rates were 100 and 90%, respectively. Grade 3 toxicity was experienced by two patients. In conclusion, the SSIACRT regimen with a lower dose of CDDP (100 mg/body) had an equivalent therapeutic outcome and lower toxic outcome compared to a higher dose of CDDP. This regimen could be an effective and safe therapeutic modality for maxillary squamous cell carcinoma except T4b and N1/2 disease.

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Authors and Affiliations

  1. Department of Otolaryngology, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Yuji Kanazawa, Hideo Shojaku, Hiromasa Takakura, Michiro Fujisaka, Hirohiko Tachino & Yukio Watanabe

  2. Department of Radiology, University of Toyama, Toyama, Japan

    Gakuto Tomizawa, Hideto Kawabe, Hiroko Shojaku & Hikaru Seto

  3. Laboratory of Pathology, Toyama University Hospital, 2630 Sugitani, Toyama, Toyama, Japan

    Kyoko Otani & Jyunya Fukuoka

Authors
  1. Yuji Kanazawa
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  2. Hideo Shojaku
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  3. Hiromasa Takakura
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  4. Michiro Fujisaka
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  5. Hirohiko Tachino
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  6. Yukio Watanabe
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  7. Gakuto Tomizawa
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  8. Hideto Kawabe
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  9. Hiroko Shojaku
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  10. Hikaru Seto
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  11. Kyoko Otani
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  12. Jyunya Fukuoka
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Corresponding author

Correspondence to Hideo Shojaku.

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Kanazawa, Y., Shojaku, H., Takakura, H. et al. An essential dose of cisplatin for super-selective intra-arterial infusion concomitant with radiotherapy in patient with maxillary squamous cell carcinoma. Eur Arch Otorhinolaryngol 269, 1985–1991 (2012). https://doi.org/10.1007/s00405-011-1857-7

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  • DOI: https://doi.org/10.1007/s00405-011-1857-7

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