The aim of the study was to determine whether celiac disease affects ovarian reserve assessed by antral follicle counting, ovarian volume, and anti-müllerian hormone in adolescent patients.
This case–control multicenter trial was performed from January 1, 2017 to May 31, 2018 and included 45 girls. On days 2–5 of the menstrual cycle, measurements of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin, and anti-müllerian hormone were performed. Antral follicle counts and ovarian volumes were determined on the same day.
Evaluation was made of 21 (47.7%) celiac patients with a mean age of 15.8 ± 1.3 years, and 24 (52.3%) healthy control subjects with a mean age of 16.2 ± 1.2. There was no difference between the groups in respect of right and left ovarian volumes (p = 0.790 and p = 0.670, respectively). Serum levels of anti-müllerian hormone of the celiac patients and controls were found comparable [(3.7 ± 2.9 (0.5–12) and 3.6 ± 1.8 (1.2–8.1)] ng/mL, respectively, p = 0.915).
Celiac disease may not affect the ovarian reserve determined with established ovarian reserve markers including antral follicle counting, ovarian volume, and anti-müllerian hormone in adolescent patients.
ClinicalTrials.gov identifier (NCT number): NCT04024449
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Antral Follicle Counts
Follicle stimulating hormone
Mili international unit
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We thank to Caroline J. Walker for English editing this paper.
The authors have not received to support our research.
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All authors declare that we have no conflict of interest in connection with this paper. All authors approved the final manuscript as submitted and agreed to be accountable for all aspects of the work.
Informed consent was obtained from all individual participants included in the study.
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Comba, C., Comba, A., Yılmaz, H. et al. Celiac disease does not influence markers of ovarian reserve in adolescent girls. Arch Gynecol Obstet (2020). https://doi.org/10.1007/s00404-020-05666-4
- Celiac disease
- Anti-müllerian hormone
- Follicle stimulating hormone
- Antral follicle counts