Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient

Abstract

Purpose

There are limited data regarding postoperative complications and autoimmune reactions caused by surgery in early-stage cervical cancer patients who underwent laparoscopic radical resection (LRR). This study aimed to investigate the therapeutic effect of LRR of cervical cancer patients and its effect on cytokines.

Methods

168 patients with cervical cancer were enrolled. The patients were divided into open group and laparoscopic group according to the random number table method, with 84 cases in each group. The surgical-related indexes and the incidence of complications of the two groups were observed, and the IFN-γ, TNF, and IL-1/2/4/6/8/10/12 levels in peripheral blood were compared before and after surgery in both groups.

Results

The operation time of the patients in the laparoscopic group was significantly shorter than that in the open group (119.56 ± 45.26 vs. 206.36 ± 54.39, P < 0.01). The intraoperative blood loss in the laparoscopic group was significantly less than that in the open group (155.29 ± 57.58 vs. 529.58 ± 162.4, P < 0.01). The postoperative visual analog scale (VAS) score was also significantly lower than that in the open group (3.65 ± 0.88 vs. 6.32 ± 1.12, P < 0.01). There was no significant difference in the incidence of complications between the two groups. The degree of inflammatory cytokines changes caused by LRR was less than that of open radical surgery (P < 0.001).

Conclusions

LRR surgery has less stress on patients with early cervical cancer than open surgery within 5 days after surgery, which has certain reference value for early cervical cancer treatment.

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Funding

This study was supported by Health Science and Technology Plan Projects of Yunnan Province (Grant Nos.: 2016NS195 and 2016NS196), Provincial Innovation Team Project of Human Assisted Reproductive Technology Research (Grant No.: 2017HC009), Martin Expert Workstation (Grant No.: 2018IC106), Special Project of Yunnan "Ten Thousand Plan · Famous Doctor" (Grant No.: YNWR-MY-2018–014), Clinical Medical Center of Yunnan Provincial Health Commission (Grant No.: ZX2019-01–01), and National Natural Science Foundation of China (Grant No.: 31700798).

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Authors

Contributions

QX: Data collection and analysis, Manuscript writing and revision. MFD: Data analysis, Literature search, Manuscript writing and revision. WD: Data analysis, Literature search, Manuscript revision. DHY: Data analysis, Literature search, Data visualization, Manuscript review. JZ: Data collection, Literature search, Manuscript review and validation. JL: Data analysis, Manuscript revision and validation. LR: Data analysis, Manuscript revision and validation, Funding acquisition, Project administrator. YF: Study design, Data collection, Manuscript writing and revision, Funding acquisition, Project administrator.

Corresponding authors

Correspondence to Li Ren or Yun Feng.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology.

Informed consent

Written informed consent was obtained from all individual participants included in the study.

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Xu, Q., Dong, M., Dong, W. et al. Postoperative comparison of laparoscopic radical resection and open abdominal radical hysterectomy for cervical cancer patient. Arch Gynecol Obstet 302, 473–479 (2020). https://doi.org/10.1007/s00404-020-05606-2

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Keywords

  • Cervical cancer
  • Laparoscopic radical resection
  • Cytokine
  • Immune function