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3D vocal power Doppler sonography for the estimation of tumor volume and vascularization in stage IB1 cervical cancer

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the tumor’s volume and intratumoral vascularization with 3D vocal power Doppler ultrasound in patients with stage 1B1 cervical cancer.

Methods

This was a prospective study on patients with cervical cancer and stage 1B1 disease, which took place between 2012 and 2015. All women had an initial 2D ultrasound examination for the estimation of the tumor volume. Following this, 3D volumes of the cervix were acquired and were further analyzed using the Virtual Organ Computer Aided Analysis (VOCAL) program. In the selected volume, the vascular pattern (linear or complex vascularization) was also examined. The ultrasonographic findings were compared to the histological ones following surgery.

Results

Twenty-seven patients were included. The average cervical tumor volume measured by the 2D ultrasound and 3D VOCAL-PD were 3.14 and 3.08 cm3, respectively. Both 2D and 3D VOCAL-PD overestimated the tumor staging. Further analysis showed a statistically significant superiority of 2D ultrasound over 3D VOCAL-PD for tumors equal or smaller than 2.5 cm3 with linear vascularity (p < 0.001), while for tumors of larger volume with complex vascularization, a statistically significant superiority of 3D VOCAL-PD was confirmed (p < 0.001).

Conclusions

3-D VOCAL-PD is extremely accurate and superior to 2D ultrasound for the estimation of tumor volume and vascularization when it is more than 2.5 cm3 and has a complex vascularization in patients with stage 1B1 cervical cancer.

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Authors and Affiliations

  1. 1st Department of Obstetrics and Gynecology, “Alexandra” Maternity Hospital, National and Kapodistrian University of Athens, 80 Vas. Sophias Av., 115 28, Athens, Greece

    George Daskalakis, Diamantis Diamantopoulos, Mariana Theodora, Anysia Semertzidou, Kaliopi Pappa, Panagiotis Antsaklis, Mihail Sindos, Alexandros Rodolakis & Konstantinos Kalmantis

  2. Institute of Reproductive and Developmental Biology, Surgery and Cancer, Imperial College London, London, UK

    Anysia Semertzidou

Authors
  1. George Daskalakis
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  2. Diamantis Diamantopoulos
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  3. Mariana Theodora
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  4. Anysia Semertzidou
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  5. Kaliopi Pappa
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  6. Panagiotis Antsaklis
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  7. Mihail Sindos
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  8. Alexandros Rodolakis
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  9. Konstantinos Kalmantis
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Contributions

GD—Project development, data collection. DD—Data analysis. MT—Data analysis. AS—Data analysis, manuscript writing/editing. KP—Manuscript writing/editing. PA—Manuscript writing/editing. MS—Manuscript writing/editing. AR—Manuscript writing/editing. KK—Project development, supervision.

Corresponding author

Correspondence to Anysia Semertzidou.

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We declare that we have no conflict of interest

Ethical approval

All procedures performed involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

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Daskalakis, G., Diamantopoulos, D., Theodora, M. et al. 3D vocal power Doppler sonography for the estimation of tumor volume and vascularization in stage IB1 cervical cancer. Arch Gynecol Obstet 298, 617–622 (2018). https://doi.org/10.1007/s00404-018-4842-1

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  • DOI: https://doi.org/10.1007/s00404-018-4842-1

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