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Archives of Gynecology and Obstetrics

, Volume 298, Issue 1, pp 27–34 | Cite as

Placenta previa and placental abruption after assisted reproductive technology in patients with endometriosis: a systematic review and meta-analysis

  • Maria Luisa Gasparri
  • Konstantinos Nirgianakis
  • Katayoun Taghavi
  • Andrea Papadia
  • Michael D Mueller
Review

Abstract

Introduction

Recent evidence suggests that assisted reproductive technology (ART) increases the risk of adverse pregnancy outcomes, including placental disorders. Similarly, endometriosis resulted detrimental on placenta previa. However, up to 50% of women with endometriosis suffer from infertility, thus requiring ART. The aim of our metanalysis is to compare women with and without endometriosis undergoing ART in terms of placenta disorders events, to establish if ART itself or endometriosis, as an indication to ART, increases the risk of placenta previa.

Methods

Literature searches were conducted in January 2018 using electronic databases (PubMed, Medline, Scopus, Embase, Science Direct, and the Cochrane Library Scopus). Series comparing pregnancy outcome after ART in women with and without endometriosis were screened and data on placenta previa and placental abruption were extracted.

Results

Five retrospective case–control studies met the inclusion criteria. The meta-analysis revealed that endometriosis is associated with an increased risk of placenta previa in pregnancies achieved through ART (OR 2.96 (95% CI 1.25–7.03); p = 0.01, I2 =69%, random-effect model). No differences in placental abruption incidence were found (OR 0.44 (95% CI 0.10–1.87); p = 0.26, I2 = 0%, fixed-effect model).

Conclusion

Patients with endometriosis undergoing ART may have additional risk of placenta previa. Despite the inability to determine if endometriosis alone or endometriosis plus ART increase the risk, physicians should be aware of the potential additional risk that endometriosis patients undergoing ART harbor.

Keywords

Placental abruption Placenta previa Assisted reproduction Endometriosis Adverse pregnancy outcome 

Notes

Author contributions

MLG was responsible for the conceptualization, literature search, data extraction, and statistical analysis. The paper was equally drafted by MLG, KN, and KT. MM and AP performed the final revision.

Compliance with ethical standards

Conflict of interest

The authors declare to have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Gynecology and ObstetricsUniversity Hospital of Bern and University of BernBernSwitzerland
  2. 2.Department of Gynecology and Obstetrics“Sapienza” University of RomeRomeItaly
  3. 3.Surgical and Medical Department of Translational Medicine“Sapienza” University of RomeRomeItaly

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