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Archives of Gynecology and Obstetrics

, Volume 297, Issue 4, pp 997–1004 | Cite as

Prognostic role of mesenteric lymph nodes involvement in patients undergoing posterior pelvic exenteration during radical or supra-radical surgery for advanced ovarian cancer

  • Roberto Berretta
  • Vito Andrea Capozzi
  • Giulio Sozzi
  • Lavinia Volpi
  • Valentina Ceni
  • Mauro Melpignano
  • Giovanna Giordano
  • Federico Marchesi
  • Michela Monica
  • Maurizio Di Serio
  • Matteo Riccò
  • Marcello Ceccaroni
Gynecologic Oncology

Abstract

Purpose

The aim of this retrospective study is to analyze the prognostic role and the practical implication of mesenteric lymph nodes (MLN) involvements in advanced ovarian cancer (AOC).

Methods

A total of 429 patients with AOC underwent surgery between December 2007 and May 2017. We included in the study 83 patients who had primary (PDS) or interval debulking surgery (IDS) for AOC with bowel resection. Numbers, characteristics and surgical implication of MLN involvement were considered.

Results

Eighty-three patients were submitted to bowel resection during cytoreduction for AOC. Sixty-seven patients (80.7%) underwent primary debulking surgery (PDS). Sixteen patients (19.3%) experienced interval debulking surgery (IDS). 43 cases (51.8%) showed MLN involvement. A statistic correlation between positive MLN and pelvic lymph nodes (PLN) (p = 0.084), aortic lymph nodes (ALN) (p = 0.008) and bowel infiltration deeper than serosa (p = 0.043) was found. A longer overall survival (OS) and disease-free survival was observed in case of negative MLN in the first 20 months of follow-up. No statistical differences between positive and negative MLN in terms of operative complication, morbidity, Ca-125, type of surgery (radical vs supra-radical), length and site of bowel resection, residual disease and site of recurrence were observed.

Conclusions

An important correlation between positive MLN, ALN and PLN was detected; these results suggest a lymphatic spread of epithelial AOC similar to that of primary bowel cancer. The absence of residual disease after surgery is an independent prognostic factor; to achieve this result should be recommended a radical bowel resection during debulking surgery for AOC with bowel involvement.

Keywords

Mesenteric lymph nodes Pelvic lymph nodes Aortic lymph nodes Ovarian cancer Bowel infiltration 

Notes

Author contributions

RB and VAC conceived the study, participated in its design and coordination and drafted the manuscript; MM, GS, MDS, MM, FM and GG participated in the design and interpretation of the data; VC and LV participated in the design and coordination of the study and performed the measurement; MR participated in the design of the study and performed the statistical analysis; MC conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

Author Capozzi Vito Andrea declare that he has no conflict of interest. Author Roberto Berretta declare that he has no conflict of interest. Author Giulio Sozzi declare that he has no conflict of interest. Author Lavinia Volpi declare that she has no conflict of interest. Author Valentina Ceni declare that she has no conflict of interest. Author Mauro Melpignano declare that he has no conflict of interest. Author Giovanna Giordano declare that she has no conflict of interest. Author Federico Marchesi declare that he has no conflict of interest. Author Michela Monica declare that she has no conflict of interest. Author Maurizio Di Serio declare that he has no conflict of interest. Author Marcello Ceccaroni declare that he has no conflict of interest. Author Matteo Riccò declare that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Roberto Berretta
    • 1
  • Vito Andrea Capozzi
    • 1
  • Giulio Sozzi
    • 1
  • Lavinia Volpi
    • 1
  • Valentina Ceni
    • 1
  • Mauro Melpignano
    • 2
  • Giovanna Giordano
    • 1
  • Federico Marchesi
    • 1
  • Michela Monica
    • 1
  • Maurizio Di Serio
    • 1
  • Matteo Riccò
    • 3
  • Marcello Ceccaroni
    • 4
  1. 1.Department of Obstetrics and Gynecology of ParmaUniversity of ParmaParmaItaly
  2. 2.The Department of Obstetrics and Gynecology of Oglio PoCremonaItaly
  3. 3.Local Health Unit of Reggio Emilia, Department of Public HealthReggio EmiliaItaly
  4. 4.Department of Obstetrics and GynecologySacred Heart Hospital of NegrarVeronaItaly

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