Archives of Gynecology and Obstetrics

, Volume 297, Issue 5, pp 1293–1299 | Cite as

Increased incidence of preeclampsia in mothers of advanced age conceiving by oocyte donation

  • Uri P. Dior
  • Neri Laufer
  • Henry H. Chill
  • Sorina Granovsky-Grisaru
  • Simcha Yagel
  • Haim Yaffe
  • Yuval Gielchinsky
Gynecologic Endocrinology and Reproductive Medicine



The aim of this study was to evaluate the risk of preeclampsia in women of advanced age who conceived through donated oocytes as compared with natural conceptions.


A historical prospective study of singleton live births of parturients ≥ 45 years of age at four university hospitals was conducted. For the purpose of the study, the population was divided by the mode of conception into two groups: oocyte donation and natural conception. The main outcome variable in this study was preeclampsia. Secondary outcomes included pregnancy-induced hypertension and Small for Gestational Age.


Two hundred and seventy pregnancies were achieved naturally and 135 women conceived by oocyte donation. Mean age at delivery for the natural conception and oocyte donation groups was 45.7 and 47.8, respectively. Preeclampsia complicated 3 out of 270 (1.1%) natural conception pregnancies and 17 out of 135 (12.6%) oocyte donation conceptions. After adjusting for confounders, oocyte donation pregnancies were found to be associated with a 12-fold increased risk for preeclampsia (P = 0.001). Among oocyte donation pregnancies, the risk of preeclampsia was not affected by parity or age.


A substantially increased risk for preeclampsia was found in oocyte donation pregnancies, suggesting that the foreign oocyte may play a specific biologic role in the development of preeclampsia after the age of 45.


Preeclampsia Assisted reproductive technology Oocyte donation Hypertension in pregnancy High-risk pregnancy 


Author contributions

UPD: project development, data collection, analysis, and writing of the manuscript. NL: project development, editing of the manuscript, and supervision. HHC: manuscript writing and editing and data analysis. SGG: project development, data analysis, and manuscript editing. HY: data collection and editing of manuscript. YG: project development, data collection, and manuscript editing.

Compliance with ethical standards


This study did not receive any funding.

Research involving human and animal participants

All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional research committee at Hadassah Medical Center, Hebrew University Medical School and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Uri P. Dior
    • 1
  • Neri Laufer
    • 1
  • Henry H. Chill
    • 1
  • Sorina Granovsky-Grisaru
    • 2
  • Simcha Yagel
    • 1
  • Haim Yaffe
    • 3
  • Yuval Gielchinsky
    • 1
  1. 1.Department of Obstetrics and GynecologyHadassah Medical Center and Hebrew University-Hadassah Medical SchoolJerusalemIsrael
  2. 2.Department of Obstetrics and GynecologyShaare-Zedek Medical Center and Hebrew University Medical SchoolJerusalemIsrael
  3. 3.Department of Obstetrics and Gynecology, Sheere-Zedek Medical Center City CampusBikur-Holim HospitalJerusalemIsrael

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