Archives of Gynecology and Obstetrics

, Volume 297, Issue 1, pp 49–60 | Cite as

Maternal sepsis in the era of genomic medicine

Review
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Abstract

Purpose

Maternal sepsis remains one of the leading causes of direct and indirect maternal mortality both in high- and low-income environments. In the last two decades, systems biology approaches, based on ‘-omics’ technologies, have started revolutionizing the diagnosis and management of the septic syndrome. The scope of this narrative review is to present an overview of the basic ‘-omics’ technologies, exemplified by cases relevant to maternal sepsis.

Methods

Narrative review of the new ‘-omics’ technologies based on a detailed review of the literature.

Results

After presenting the main ‘omics’ technologies, we discuss their limitations and the need for integrated approaches that encompass research efforts across multiple ‘-omics’ layers in the ‘-omics’ cascade between the genome and the phenome.

Conclusions

Systems biology approaches are revolutionizing the research landscape in maternal sepsis. There is a need for increased awareness, from the side of health practitioners, as a requirement for the effective implementation of the new technologies in the research and clinical practice in maternal sepsis.

Keywords

Maternal sepsis Genomic medicine Systems biology Integrated ‘-omics’ 

Notes

Author contributions

CK: conception, project development, literature research and manuscript writing. NE: conception, project development and manuscript writing/editing. AB: conception and manuscript editing. FK: conception and manuscript editing.

Compliance with ethical standards

Funding

None.

Conflict of interest

All authors declare that they have no conflict of interest related to the article.

Ethical approval

This review article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Obstetrics and Perinatal MedicineKlinik HallerwieseNurembergGermany
  2. 2.Intensive Care Medicine Unit, Department of Respiratory Medicine, Allergology and Sleep MedicineParacelsus Medical UniversityNurembergGermany
  3. 3.UNU-MERIT (Maastricht Economic and Social Research Institute on Innovation and Technology)Maastricht UniversityMaastrichtThe Netherlands
  4. 4.Public Health Genomics, Department International HealthMaastricht UniversityMaastrichtThe Netherlands
  5. 5.Professorial Fellow, UNU-MERIT (Maastricht Economic and Social Research Institute on Innovation and Technology)Maastricht UniversityMaastrichtThe Netherlands
  6. 6.Dr. TMA Pai Endowed Chair Public Health GenomicsManipal UniversityManipalIndia

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