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Thorax-to-head ratio and defect diameter-to-head ratio in giant omphaloceles as predictor for fetal outcome

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

To investigate the relationship between the thorax diameter and defect diameter of giant omphaloceles as a predictor for fetal outcome.

Methods

In a retrospective study, 17 fetuses with isolated giant omphaloceles were included for evaluation. The anterior–posterior thorax diameter and the defect diameter were measured from ultrasound images. For analysis, the thorax-to-head ratio (T/HC), the defect diameter-to-head ratio (DD/HC), and the quotient of the defect diameter and the thorax diameter (DD/T) were calculated. The days of ventilation (t ventilation), the duration until hospital discharge (t hospital), and the type of treatment were recorded as outcome parameters.

Results

No relationship was found between the calculated ratios (T/HC, DD/HC, or DD/T) and neither t hospital (r = −0.418, p = 0.095; r = −0.153, p = 0.556; and r = −0.023, p = 0.929; respectively) nor t ventilation (r = −0.391, p = 0.121; r = 0.041, p = 0.875; and r = 0.121, p = 0.645, respectively). The type of postnatal treatment was not associated with the three calculated ratios or t hospital (r = 0.155, p = 0.553; r = 0.019, p = 0.942; and r = 0.012, p = 0.965; r = −0.009, p = 0.973, respectively). In 53% of cases, t hospital was delayed due to additional and independent postnatal complications.

Conclusion

Thorax diameter or defect diameter of giant omphaloceles is not predictive for fetal outcome. The perinatal care of these abdominal wall defects still remains a multidisciplinary challenge, but the outcome of giant omphaloceles is favorable at experienced centers.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany

    Nina Diemon, Mareike Möllers, Kerstin Hammer, Walter Klockenbusch & Ralf Schmitz

  2. Department of Pediatric Surgery, University Hospital of Münster, Münster, Germany

    Katrin Funke & Volker Müller

  3. Department of Fetal Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany

    Johannes Steinhard

  4. Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany

    Cristina Sauerland

Authors
  1. Nina Diemon
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  2. Katrin Funke
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  3. Mareike Möllers
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  4. Kerstin Hammer
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  5. Johannes Steinhard
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  6. Cristina Sauerland
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  7. Volker Müller
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  8. Walter Klockenbusch
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Corresponding author

Correspondence to Nina Diemon.

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None declared.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The institutional review board approved this study and required neither patient approval nor informed consent for our retrospective analysis of data that were obtained using a standard of care clinical protocol.

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Diemon, N., Funke, K., Möllers, M. et al. Thorax-to-head ratio and defect diameter-to-head ratio in giant omphaloceles as predictor for fetal outcome. Arch Gynecol Obstet 295, 325–330 (2017). https://doi.org/10.1007/s00404-016-4236-1

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  • DOI: https://doi.org/10.1007/s00404-016-4236-1

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