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Mifepristone combined with ethacridine lactate for the second-trimester pregnancy termination in women with placenta previa and/or prior cesarean deliveries

  • General Gynecology
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Abstract

Purpose

This study was aimed to evaluate the safety and efficacy of the second-trimester medical abortions using mifepristone and ethacridine lactate in women with placenta previa and/or prior cesarean deliveries.

Methods

The patients who underwent a second-trimester pregnancy termination from January 2009 to December 2015 were retrospectively analyzed. The eligible patients were assigned to four groups based on placentation and cesarean history. The abortion interval (AI), blood loss, hospital stays, incidence of curettage, and transfusion were reviewed.

Results

Two women underwent cesarean sections for placenta increta. Finally, 443 patients were enrolled in this study, including 92 with placenta previa, 153 with prior cesarean deliveries, 36 with the both factors, and 236 with normal placentation and no cesarean delivery history. All the included cases had a successful vaginal delivery. There was no significant difference in AI, hospital stay, rate of hemorrhage, and transfusion among the four groups. Patients with prior cesarean section had higher blood loss than the normal group (P = 0.0017), as well as patients with both placenta previa and prior cesarean (P = 0.0018). However, there was no obvious blood loss in patients with placenta previa when compared with normal placetal patients (P = 0.23). No uterine rupture occurred in all patients.

Conclusions

Mifepristone combined with ethacridine lactate is safe and effective for patients with low placentation or/and prior cesarean in the second-trimester pregnancy termination.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 650, Xinsongjiang Road, Songjiang District, Shanghai, 200080, China

    Chunqin Chen, Feikai Lin, Xiaoyun Wang, Yaping Jiang & Sufang Wu

  2. Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated With Tong Ji University, Shanghai, China

    Feikai Lin

Authors
  1. Chunqin Chen
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  2. Feikai Lin
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  3. Xiaoyun Wang
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  4. Yaping Jiang
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  5. Sufang Wu
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Corresponding authors

Correspondence to Yaping Jiang or Sufang Wu.

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Funding

This work was supported by the National Natural Science Foundation of China (NSFC, No. 81201541) and The Shanghai Pugiang Talent Program (12PJD002) and the National Key Clinical Specialist Construction Programs of China.

Conflict of interest

The authors have no conflicts of interest relevant to this article.

Ethical approval

This study was approved by the Ethics Committee of Shanghai General People’s Hospital Affiliated to Shanghai Jiaotong University. The procedures were performed in accordance with the principle of the Declaration of Helsinki and subsequent amendments. Informed consent was obtained from each participant prior to treatment.

Additional information

C. Chen and F. Lin co-first authors.

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Chen, C., Lin, F., Wang, X. et al. Mifepristone combined with ethacridine lactate for the second-trimester pregnancy termination in women with placenta previa and/or prior cesarean deliveries. Arch Gynecol Obstet 295, 119–124 (2017). https://doi.org/10.1007/s00404-016-4205-8

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  • DOI: https://doi.org/10.1007/s00404-016-4205-8

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