Archives of Gynecology and Obstetrics

, Volume 285, Issue 3, pp 853–856 | Cite as

Prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome

  • Maryam Kachuei
  • Fatemeh Jafari
  • Ali Kachuei
  • Ammar H. Keshteli
Reproductive Medicine



Hypothyroidism is associated with pregnancy complications both for the mother and progeny and it should be considered in reproductive age. Thyroid autoimmunity is stated to be the main cause of hypothyroidism in iodine sufficient areas. Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder affecting women in reproductive age. Early diagnosis and treatment of hypothyroidism in PCOS may reduce the rate of infertility and pregnancy-related morbidity. In the present study we evaluated thyroid autoimmunity in PCOS patients.


Over a period of 12 months, 78 patients with PCOS were recruited to this case–control study. Three hundred and fifty age-matched women were studied as a control group. PCOS was defined according to the revised 2003 Rotterdam criteria. Thyroid size was estimated by inspection and palpation. Serum thyroid stimulating hormone (TSH), anti-thyroperoxidase antibody (anti-TPO Ab), and anti-thyroglobulin antibody (anti-Tg Ab) were measured.


The mean ± SD of serum anti-TPO Ab in PCOS patients and subjects in the control group was 216 ± 428 and 131 ± 364 IU/mL, respectively (P = 0.04). Prevalence of goiter in PCOS patients was higher than that in control subjects (62.3 vs. 35.7%, P = 0.0001). Serum TSH and anti-Tg Ab in PCOS patients and control subjects did not differ significantly.


In this case–control study, anti-thyroid antibodies and goiter prevalence were significantly higher in PCOS patients. These data suggest that thyroid exam and evaluation of thyroid function and autoimmunity should be considered in such patients.


Autoimmune thyroiditis Anti-thyroperoxidase antibody Anti-thyroglobulin antibody Polycystic ovary syndrome 



We would like to thank all the staff at Isfahan Endocrine and Metabolism Research Centre for their great cooperation with us. We are also thankful to the participants in the present study. This study was funded by the Vice Chancellery for Research and Technology, Isfahan University of Medical Sciences.

Conflict of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.


  1. 1.
    Burek C, Rose N (2008) Autoimmune thyroiditis and ROS. Autoimmun Rev 7:530–537PubMedCrossRefGoogle Scholar
  2. 2.
    Kostoglou-Athanassiou I, Ntalles K (2010) Hypothyroidism—new aspects of an old disease. Hippokratia 14:82–87PubMedGoogle Scholar
  3. 3.
    Poppe K, Velkeniers B, Glinoer D, Medscape (2008) The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab 4:394–405PubMedCrossRefGoogle Scholar
  4. 4.
    Tomer Y, Huber A (2009) The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmun 32:231–239PubMedCrossRefGoogle Scholar
  5. 5.
    Khalili N, Hashemipour M, Keshteli AH, Siavash M, Amini M (2009) The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. J Endocrinol Invest 32:899–902PubMedGoogle Scholar
  6. 6.
    Hashemipour M, Amini M, Aminorroaya A et al (2007) High prevalence of goiter in an iodine replete area: do thyroid auto-antibodies play a role? Asia Pac J Clin Nutr 16:403–410PubMedGoogle Scholar
  7. 7.
    Brent GA, Larsen PR, Davies TF (2008) Hypothyroidism and thyroiditis. In: Kronenberg HM, Melmed S, Polonsly KS, Larsen PR (eds) Williams text book of endocrinology, 11th edn. Saunders, Philadelphia, pp 378–383Google Scholar
  8. 8.
    Escobar-Morreale HF (2008) Polycystic ovary syndrome: treatment strategies and management. Expert Opin Pharmacother 9:2995–3008PubMedCrossRefGoogle Scholar
  9. 9.
    Rosenfield RL (2008) What every physician should know about polycystic ovary syndrome. Dermatol Ther 21:354–361PubMedCrossRefGoogle Scholar
  10. 10.
    Mascitelli L, Pezzetta F (2005) Polycystic ovary syndrome. N Engl J Med 352:2756–2757 (author reply 2756-2757)PubMedCrossRefGoogle Scholar
  11. 11.
    Boomsma C, Fauser B, Macklon N (2008) Pregnancy complications in women with polycystic ovary syndrome. Semin Reprod Med 26:72–84PubMedCrossRefGoogle Scholar
  12. 12.
    group REA-SPcw (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41–47CrossRefGoogle Scholar
  13. 13.
    World Health Organization (2001) United Nations Children’s Fund and International Council for the Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their eliminationGoogle Scholar
  14. 14.
    Markou KB, Georgopoulos NA, Makri M et al (2003) Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies. J Endocrinol Invest 26:43–48PubMedGoogle Scholar
  15. 15.
    Janssen O, Mehlmauer N, Hahn S, Offner A, Gartner R (2004) High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Eur J Endocrinol 150:363–369PubMedCrossRefGoogle Scholar
  16. 16.
    Ott J, Aust S, Kurz C, Nouri K, Wirth S, Huber JC et al (2010) Elevated antithyroid peroxidase antibodies indicating Hashimoto’s thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome. Fertil Steril 94:2895–2897PubMedCrossRefGoogle Scholar
  17. 17.
    Giza S, Galli-Tsinopoulou A, Lazidou P, Trachana M, Goulis D (2008) HLA-DQB1*05 association with Hashimoto’s thyroiditis in children of Northern Greek origin. Indian Pediatr 45:493–496PubMedGoogle Scholar
  18. 18.
    Prapas N, Karkanaki A, Prapas I et al (2009) Genetics of polycystic ovary syndrome. Hippokratia 13:216–223PubMedGoogle Scholar
  19. 19.
    Hefler-Frischmuth K, Walch K, Huebl W et al (2010) Serologic markers of autoimmunity in women with polycystic ovary syndrome. Fertil Steril 93:2291–2294PubMedCrossRefGoogle Scholar
  20. 20.
    Lahita R (1999) The role of sex hormones in systemic lupus erythematosus. Curr Opin Rheumatol 11:352–356PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Maryam Kachuei
    • 1
  • Fatemeh Jafari
    • 2
  • Ali Kachuei
    • 2
  • Ammar H. Keshteli
    • 3
  1. 1.Medical Students’ Research CenterIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Endocrinology and Internal Medicine, Isfahan Endocrine and Metabolism Research CenterIsfahan University of Medical SciencesIsfahanIran
  3. 3.Integrative Functional Gastroenterology Research CenterIsfahan University of Medical SciencesIsfahanIran

Personalised recommendations