Evaluation of serum uric acid levels in patients with rosacea


Rosacea is an inflammatory skin disease with a chronic course. Although the pathogenesis of rosacea is not completely understood, it is regarded as an inflammatory process. The aim of the present study was to evaluate uric acid (UA) levels in patients with rosacea and to detect the correlation of UA levels with disease activity. A total of 61 patients with rosacea and 64 sex- and age-matched controls were included in the study. Demographic characteristics, medical history, and dermatological examination of the patient and control groups were recorded. Concentrations of serum UA and C-reactive protein (CRP) were evaluated and compared in both groups. This study included 61 patients with rosacea (39 females, 22 males, median age = 30 years) and 64 age- and sex-matched controls. Metabolic syndrome was significantly more common in patients with rosacea than in the control group. Patients with rosacea had significantly higher body mass index (BMI) values compared with those of controls. Serum UA and CRP values were significantly higher in the rosacea group than values in the control group. There was no statistically significant correlation between serum UA level and clinical rosacea severity. This study suggests that rosacea is not only a skin-related disease but also an inflammatory disease that can be related to higher uric acid levels, BMI values, and metabolic syndrome. It may be recommended that clinicians pay careful attention to the clinical follow-up of these patients to avoid missed associated comorbidities.

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The authors declare that there are no relationships that provided financial or editorial support for the study which may in potential cause competing interest for the submission.

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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Nermin Karaosmanoglu, Engin Karaaslan and Pınar Ozdemir Cetinkaya. The first draft of the manuscript was written by Nermin Karaosmanoglu and Pınar Ozdemir Cetinkaya and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Pınar Ozdemir Cetinkaya.

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Karaosmanoglu, N., Karaaslan, E. & Ozdemir Cetinkaya, P. Evaluation of serum uric acid levels in patients with rosacea. Arch Dermatol Res 312, 447–451 (2020). https://doi.org/10.1007/s00403-020-02033-w

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  • C-reactive protein
  • Rosacea
  • Uric acid