Skip to main content
Log in

Pain relieve without impairing muscle function after local infiltration anaesthesia in primary knee arthroplasty: a prospective randomized study

  • Knee Arthroplasty
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Purpose

Purpose of the current study was to compare early effectiveness of pain relieve of 3 in 1 regional pain catheter to local infiltration anesthesia (LIA) in primary total knee arthroplasty (TKA). Secondary endpoint was quadriceps muscle strength after both procedures.

Material and methods

A single-center, prospective, randomized controlled trial was performed. Patients eligible to TKA were either randomized into group 3 in 1 regional pain catheter (C), or group local infiltration anesthesia (L). Pain relieve was assessed by visual analogue scale (VAS) at rest and under physical activity (PA) prior to surgery (t0) and at days one through six. In addition, quadriceps muscle strength ( = straight leg raise) was tested according to the Manual Muscle Testing Scale. Functional outcome was measured using the Oxford Knee Score (OKS) preoperatively and 6 months postoperatively.

Results

121 patients were included in the study. 59 (48.8%) patients were allocated to group C, 62 (51.2%) patients to Group L. No differences concerning pain level evaluated by VAS could be detected between the groups at any time. Comparing straight leg raise test group L was significantly superior over the complete postoperative period (p < 0.03). The mean OKS decreased significantly (p < 0.001) from preoperatively 34.2 ± 7.5 points to 16.9 ± 6.0 points at the six months final follow-up. Regarding OKS there were no intergroup differences at the final follow-up at 6 months postoperative.

Conclusion

There is no significant difference in pain relieve comparing LIA to 3 in 1 catheter in perioperative pain management in TKA. The advantage of LIA is unimpaired quadriceps muscle function in the short-term follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Gerbershagen HJ, Aduckathil S, van Wijck AJ, Peelen LM, Kalkman CJ, Meissner W (2013) Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures. Anesthesiology 118:934–944

    Article  PubMed  Google Scholar 

  2. Wright D, Hoang M, Sofine A, Silva JP, Schwarzkopf R (2017) Pain catastrophizing as a predictor for postoperative pain and opiate consumption in total joint arthroplasty patients. Arch Orthop Trauma Surg. 137(12):1623–1629

    Article  PubMed  Google Scholar 

  3. Clement ND, Macdonald D, Burnett R, Simpson AH, Howie CR (2017) A patient's perception of their hospital stay influences the functional outcome and satisfaction of total knee arthroplasty. Arch Orthop Trauma Surg. 137(5):693–700

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Barrington JW, Halaszynski TM, Sinatra RS (2014) Expert Working Group On A, Orthopaedics Critical Issues In H, Knee Replacement Arthroplasty FT. Perioperative pain management in hip and knee replacement surgery. Am J Orthop (Belle Mead NJ) 43:1–16

    Google Scholar 

  5. Carli F, Clemente A, Asenjo JF, Kim DJ, Mistraletti G, Gomarasca M, Morabito A, Tanzer M (2010) Analgesia and functional outcome after total knee arthroplasty: periarticular infiltration vs continuous femoral nerve block. Br J Anaesth 105:185–195

    Article  CAS  PubMed  Google Scholar 

  6. Ha CW, Park YB, Song YS, Kim JH, Park YG (2016) Increased Range of Motion Is Important for Functional Outcome and Satisfaction After Total Knee Arthroplasty in Asian Patients. J Arthroplasty 31:1199–1203

    Article  PubMed  Google Scholar 

  7. Albrecht E, Guyen O, Jacot-Guillarmod A, Kirkham KR (2016) The analgesic efficacy of local infiltration analgesia vs femoral nerve block after total knee arthroplasty: a systematic review and meta-analysis. Br J Anaesth 116:597–609

    Article  CAS  PubMed  Google Scholar 

  8. Matsumoto S, Matsumoto K, Lida H (2015) Transdermal fentanyl patch improves post-operative pain relief and promotes early functional recovery in patients undergoing primary total knee arthroplasty: a prospective, randomised, controlled trial. Arch Orthop Trauma Surg. 135(9):1291–1297

    Article  PubMed  Google Scholar 

  9. Wiesmann T, Piechowiak K, Duderstadt S, Haupt D, Schmitt J, Eschbach D, Feldmann C, Wulf H, Zoremba M, Steinfeldt T (2016) Continuous adductor canal block versus continuous femoral nerve block after total knee arthroplasty for mobilisation capability and pain treatment: a randomised and blinded clinical trial. Arch Orthop Trauma Surg. 136(3):397–406

    Article  PubMed  Google Scholar 

  10. Chaumeron A, Audy D, Drolet P, Lavigne M, Vendittoli PA (2013) Periarticular injection in knee arthroplasty improves quadriceps function. Clin Orthop Relat Res 471:2284–2295

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ashraf A, Raut VV, Canty SJ, McLauchlan GJ (2013) Pain control after primary total knee replacement. A prospective randomised controlled trial of local infiltration versus single shot femoral nerve block. Knee 20:324–327

    Article  PubMed  Google Scholar 

  12. Fan L, Zhu C, Zan P, Yu X, Liu J, Sun Q, Li G (2015) The Comparison of Local Infiltration Analgesia with Peripheral Nerve Block following Total Knee Arthroplasty (TKA): A Systematic Review with Meta-Analysis. J Arthroplasty 30:1664–1671

    Article  PubMed  Google Scholar 

  13. Kurosaka K, Tsukada S, Seino D, Morooka T, Nakayama H, Yoshiya S (2016) Local Infiltration Analgesia Versus Continuous Femoral Nerve Block in Pain Relief After Total Knee Arthroplasty: A Randomized Controlled Trial. J Arthroplasty 31:913–917

    Article  PubMed  Google Scholar 

  14. Fu H, Wang J, Zhang W, Cheng T, Zhang X (2017) Potential superiority of periarticular injection in analgesic effect and early mobilization ability over femoral nerve block following total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 25:291–298

    Article  PubMed  Google Scholar 

  15. Wang C, Cai XZ, Yan SG (2015) Comparison of Periarticular Multimodal Drug Injection and Femoral Nerve Block for Postoperative Pain Management in Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. J Arthroplasty 30:1281–1286

    Article  PubMed  Google Scholar 

  16. Yun XD, Yin XL, Jiang J, Teng YJ, Dong HT, An LP, Xia YY (2015) Local infiltration analgesia versus femoral nerve block in total knee arthroplasty: a meta-analysis. Orthop Traumatol Surg Res 101:565–569

    Article  PubMed  Google Scholar 

  17. Teng Y, Jiang J, Chen S, Zhao L, Cui Z, Khan MS, Du W, Gao X, Wang J, Xia Y (2014) Periarticular multimodal drug injection in total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 22:1949–1957

    Article  PubMed  Google Scholar 

  18. Moghtadaei M, Farahini H, Faiz SH, Mokarami F, Safari S (2014) Pain Management for Total Knee Arthroplasty: Single-Injection Femoral Nerve Block versus Local Infiltration Analgesia. Iran Red Crescent Med J 16:e13247. https://doi.org/10.5812/ircmj.13247

    Article  PubMed  PubMed Central  Google Scholar 

  19. Rostlund T, Kehlet H (2007) High-dose local infiltration analgesia after hip and knee replacement–what is it, why does it work, and what are the future challenges? Acta Orthop 78:159–161

    Article  PubMed  Google Scholar 

  20. Kerr DR, Kohan L (2008) Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients. Acta Orthop 79:174–183

    Article  PubMed  Google Scholar 

  21. Schulz KF, Altman DG, Moher D; CONSORT Group (2010) CONSORT 2010 Statement: updated guidelines for reporting parallel group randomized trials. Open Med 4(1):e60–68

    Google Scholar 

  22. Nakai T, Tamaki M, Nakamura T, Nakai T, Onishi A, Hashimoto K (2013) Controlling pain after total knee arthroplasty using a multimodal protocol with local periarticular injections. J Orthop. 10(2):92–94

    Article  PubMed  PubMed Central  Google Scholar 

  23. Mayr HO, Entholzner E, Hube R, Hein W, Weig TG (2007) Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair. Arch Orthop Trauma Surg. 127(4):241–244

    Article  PubMed  Google Scholar 

  24. Guild GN 3rd, Galindo RP, Marino J, Cushner FD, Scuderi GR (2015) Periarticular regional analgesia in total knee arthroplasty: a review of the neuroanatomy and injection technique. Orthop Clin North Am 46:1–8

    Article  PubMed  Google Scholar 

  25. Bohannon RW (2001) Measuring knee extensor muscle strength. Am J Phys Med Rehabil 80(1):13–18

    Article  CAS  PubMed  Google Scholar 

  26. Reito A, Jarvisto A, Jamsen E, Skytta E, Remes V, Huhtala H, Niemelainen M, Eskelinen A (2017) Translation and validation of the 12-item Oxford knee score for use in Finland. BMC Musculoskelet Disord 18:74

    Article  PubMed  PubMed Central  Google Scholar 

  27. Maempel JF, Clement ND, Brenkel IJ, Walmsley PJ (2016) Range of movement correlates with the Oxford knee score after total knee replacement: A prediction model and validation. Knee 23:511–516

    Article  PubMed  Google Scholar 

  28. Maempel JF, Clement ND, Brenkel IJ, Walmsley PJ (2015) Validation of a prediction model that allows direct comparison of the Oxford Knee Score and American Knee Society clinical rating system. Bone Jt J 97-B:503–509

    Article  CAS  Google Scholar 

  29. Harris K, Lim CR, Dawson J, Fitzpatrick R, Beard DJ, Price AJ (2015) The Oxford knee score and its subscales do not exhibit a ceiling or a floor effect in knee arthroplasty patients: an analysis of the National Health Service PROMs data set. Knee Surg Sports Traumatol Arthrosc 25(9):2736–2742

    Article  PubMed  Google Scholar 

  30. Fowler SJ, Symons J, Sabato S, Myles PS (2008) Epidural analgesia compared with peripheral nerve blockade after major knee surgery: a systematic review and meta-analysis of randomized trials. Br J Anaesth 100:154–164

    Article  CAS  PubMed  Google Scholar 

  31. Mayr HO, Entholzner E, Hube R, Hein W, Weig TG (2007) Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair. Arch Orthop Trauma Surg 127:241–244

    Article  PubMed  Google Scholar 

  32. Affas F, Nygards EB, Stiller CO, Wretenberg P, Olofsson C (2011) Pain control after total knee arthroplasty: a randomized trial comparing local infiltration anesthesia and continuous femoral block. Acta Orthop 82:441–447

    Article  PubMed  PubMed Central  Google Scholar 

  33. Sakai N, Nakatsuka M, Tomita T (2016) Patient-controlled bolus femoral nerve block after knee arthroplasty: quadriceps recovery, analgesia, local anesthetic consumption. Acta Anaesthesiol Scand 60:1461–1469

    Article  CAS  PubMed  Google Scholar 

  34. Li J, Deng X, Jiang T (2016) Combined femoral and sciatic nerve block versus femoral and local infiltration anesthesia for pain control after total knee arthroplasty: a meta-analysis of randomized controlled trials. J Orthop Surg Res 11(1):158 (review)

    Article  PubMed  PubMed Central  Google Scholar 

  35. Tanikawa H, Harato K, Ogawa R, Sato T, Kobayashi S, Nomoto S, Niki Y, Okuma K (2017) Local infiltration of analgesia and sciatic nerve block provide similar pain relief after total knee arthroplasty. J Orthop Surg Res 12:109

    Article  PubMed  PubMed Central  Google Scholar 

  36. Stathellis A, Fitz W, Schnurr C, Koeck FX, Gebauer M, Huth J, Bauer G, Beckmann J (2017) Periarticular injections with continuous perfusion of local anaesthetics provide better pain relief and better function compared to femoral and sciatic blocks after TKA: a randomized clinical trial. Knee Surg Sports Traumatol Arthrosc 25(9):2702–2707

    Article  CAS  PubMed  Google Scholar 

  37. Zhang LK, Ma JX, Kuang MJ, Ma XL (2018) Comparison of periarticular local infiltration analgesia with femoral nerve block for total knee arthroplasty: a meta-analysis of randomized controlled trials. J Arthroplasty 33(6):1972–1978 (review

    Article  PubMed  Google Scholar 

  38. Rodriguez-Merchan EC (2018) Single Local Infiltration Analgesia (LIA) Aids Early Pain Management After Total Knee Replacement (TKR): an Evidence-Based Review and Commentary. HSS J 14(1):47–49 (review

    Article  PubMed  Google Scholar 

  39. Alattas SA, Smith T, Bhatti M, Wilson-Nunn D, Donell S (2016) Greater pre-operative anxiety, pain and poorer function predict a worse outcome of a total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 25(11):3403–3410

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding and acknowledgements

The study was supported by Dr. Schaedel-Dantscher’s Foundation for medical research. The authors thank for the support.

Author information

Authors and Affiliations

Authors

Contributions

All authors have participated in the research of the current study.

Corresponding author

Correspondence to Amelie Stoehr.

Ethics declarations

Conflict interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethics approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

A written consent to participate was collected from every participant.

Additional information

Publisher Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations'.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mayr, H.O., Prall, W.C., Haasters, F. et al. Pain relieve without impairing muscle function after local infiltration anaesthesia in primary knee arthroplasty: a prospective randomized study. Arch Orthop Trauma Surg 139, 1007–1013 (2019). https://doi.org/10.1007/s00402-019-03194-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00402-019-03194-8

Keywords

Navigation