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Solitary fibrous tumor in the cervical spine with destructive vertebral involvement: a case report and review of the literature

  • Orthopaedic Surgery
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Introduction

Recently, solitary fibrous tumors occurring in spine-related lesions have been reported. However, the destruction of vertebral bodies by this type of tumor has not been reported.

Materials and methods

A 71-year-old female presented with pain from a mass on the right side of her neck. Plain radiographs of the cervical spine showed collapse of the C5 vertebral body and dislocation of the C4 vertebral body. The MRI image showed a large mass surrounding C4 and C5, which had low signal intensity in the T1W image and high signal intensity in the T2W image. At first, resection of the tumor and spinal fusion was performed by anterior approach.

Results

Histology revealed a solitary fibrous tumor with proliferating spindle cells. Immunohistochemistry showed positive stains for vimentin and CD34. One year postoperatively, a local recurrence manifested extensive destruction of the C4 and C5 vertebral bodies. Then, palliative surgery with posterior cervical instrumentation and radiation therapy were performed. Because the destruction proceeded and the rods were broken 2 years after, she underwent additional occipito-cervical instrumentation.

Conclusions

This is the first report of a solitary fibrous tumor that involves the destruction of the spinal structure. An extensive destruction of the vertebral body by the solitary fibrous tumor needs to be aware in treating this tumor with spinal involvement.

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References

  1. Alston SR, Francel PC, Jane JA Jr (1997) Solitary fibrous tumor of spinal cord. Am J Surg Pathol 21:477–483

    Article  PubMed  CAS  Google Scholar 

  2. Bohinski RJ, Mendel E, Aldape KD, Rhines LD (2004) Intramedullary and extramedullary solitary fibrous tumor of the cervical spine. Case report and review of the literature. J Neurosurg (Spine4) 100:358–363

    Google Scholar 

  3. Donnellan RB, Govender D, Chite SH, Landers AT (2000) An unusual presentation of solitary fibrous tumor. Spine 25:749–751

    Article  PubMed  CAS  Google Scholar 

  4. Endo K, Komagata M, Ikegami H, Nishiyama M, Tanaka S, Imakiire A, Serizawa H (2003) Dumbbell-type solitary fibrous tumor in the cervical spine. J Orthop Sci 8(3):428–431

    Article  PubMed  Google Scholar 

  5. England DM, Hochholzer L, McCarthy MJ (1989) Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol 13:640–658

    PubMed  CAS  Google Scholar 

  6. Fukunaga M, Naganuma H, Ushigome S, Endo Y, Ishikawa E (1996) Malignant solitary fibrous tumor of the peritoneum. Histopathology 28: 463–466

    Article  PubMed  CAS  Google Scholar 

  7. Fukunaga M, Ushigome S, Nomura K, Ishikawa E (1995) Solitary fibrous tumor of the nasal cavity and orbit. Pathol Int 45:952–957

    PubMed  CAS  Google Scholar 

  8. Gelb AB, Simmons ML, Weidner N (1996) Solitary fibrous tumor involving the renal capsule. Am J Surg Pathol 20:1288–1295

    Article  PubMed  CAS  Google Scholar 

  9. Goodlad JR, Fletcher CDM (1991) Solitary fibrous tumor arising at unusual sites: analysis of a series. Histopathology 19:515–522

    Article  PubMed  CAS  Google Scholar 

  10. Gunhan O, Yildiz FR, Celasun B, Onder T, Finci R (1994) Solitary fibrous tumor arising from sublingual gland: report of a case. J Laryngol Otol 108:998–1000

    Article  PubMed  CAS  Google Scholar 

  11. Hirakawa A, Miyamoto K, Hosoe H, Nishimoto Y, Shimokawa K, Shimizu K (2004) Solitary fibrous tumor in the occipitocervical region: a case report. Spine 29:E547–E550

    Article  PubMed  Google Scholar 

  12. Jallo GI, Roonprapunt C, Kothbauer K, Freed D, Allen J, Epstein F (2005) Spinal solitary fibrous tumors: a series of four patients: case report. Neurosurgery 57(1):E195

    Article  PubMed  Google Scholar 

  13. Kataoka H, Akiyama Y, Kubo S, Itoh H, Hamasuna R, Tajima N et al (1999) Solitary fibrous tumor of the spinal nerve rootlet: case report and literature survey. Pathol Int 49:826–830

    Article  PubMed  CAS  Google Scholar 

  14. Kawamura S, Nakamura T, Oya T, Ishizawa S, Sakai Y, Tanaka T, Saito S, Fukuoka J (2007) Advanced malignant solitary fibrous tumor in pelvis responding to radiation therapy. Pathol Int 57(4):213–218

    Article  PubMed  Google Scholar 

  15. Kawamura M, Izawa K, Hosono N, Hirano H (2004) Solitary fibrous tumor of the spinal cord: case report and review of the literature. Neurosurgery 55(2):433

    Article  PubMed  Google Scholar 

  16. Kim KA, Gonzalez I, McComb JG, Giannotta SL (2004) Unusual presentations of cerebral solitary fibrous tumors: report of four cases. Neurosurgery 54(4):1004–1009

    Article  PubMed  Google Scholar 

  17. Klemperer P, Rabin CB (1931) Primary neoplasms of the pleura. A report of five cases. Arch Pathol 11:385–412

    Google Scholar 

  18. Kurtkaya O, Elmaci I, Sav A, Pamir MN (2001) Spinal solitary fibrous tumor: seventh reported case and review of the literature. Spinal Cord 39(1):57–60. Review

    Article  PubMed  CAS  Google Scholar 

  19. Malek AM, Weller SJ, Price DL Jr (1997) Solitary fibrous tumor presenting as a symptomatic intraspinal mass: case report. Neurosurgery 40:844–847

    Article  PubMed  CAS  Google Scholar 

  20. Mentzel T, Bainbridge TC, Katenkamp D (1997) Solitary fibrous tumor: clinicopathological, immunohistochemical, and ultrastructural analysis of 12 cases arising in soft tissues, nasal cavity and nasopharynx, urinary bladder and prostate. Virchows Arch 430:445–453

    Article  PubMed  CAS  Google Scholar 

  21. Metellus P, Bouvier C, Guyotat J, Fuentes S, Jouvet A, Vasiljevic A, Giorgi R, Dufour H, Grisoli F, Figarella-Branger D (2007) Solitary fibrous tumors of the central nervous system: clinicopathological and therapeutic considerations of 18 cases. Neurosurgery 60(4):715–722

    Article  PubMed  Google Scholar 

  22. Mordani JP, Haq IU, Singh J (2000) Solitary fibrous tumour of the spinal cord. Neuroradiology 42:679–681

    Article  PubMed  CAS  Google Scholar 

  23. Nakamura Y, Okajima K, Otsuka F, Ohara K (2007) Solitary fibrous tumor attached to the cervical vertebra. Dermatol Surg 33(4):500–504

    Article  PubMed  CAS  Google Scholar 

  24. Obara Y, Matsumoto M, Chiba K, Yabe H, Toyama Y, Mukai M (2003) Solitary cervical fibrous tumor. Case illustration. J Neurosurg (Spine1) 98:111

    Google Scholar 

  25. Ogawa T, Moriyama E, Beck H, Sonobe H (2005) Soritary fibrous tumor of the thoracic spinal cord. Neurol Med Chir(Tokyo) 45:371–374

    Article  Google Scholar 

  26. Ogungbo B, Prakash S, Kulkarni G, Bradey N, Marks SM, Scoones D (2005) Cervical intra-/extramedullary solitary fibrous tumour. Br J Neurosurg 19(3):254–257

    Article  PubMed  CAS  Google Scholar 

  27. Pakasa NM, Pasquier B, Chambonniere ML, Morrison AL, Khaddage A, Perret AG, Dumollard JM, Barral FG, Peoc’h M (2005) Atypical presentations of solitary fibrous tumors of the central nervous system: an analysis of unusual clinicopathological and outcome patterns in three new cases with a review of the literature. Virchows Arch 447(1):81–86

    Article  PubMed  Google Scholar 

  28. Perry A, Scheithauer BW, Nascimento AG (1997) The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. Am J Surg Pathol 21:1354–1360

    Article  PubMed  CAS  Google Scholar 

  29. Piana S, Putrino I, Cavazza A, Nigrisoli E (2004) Solitary fibrous tumor of the spinal nerve rootlet: report of a case mimicking schwannoma. Arch Pathol Lab Med 128(3):335–337

    PubMed  Google Scholar 

  30. Pizzolitto S, Falconieri G, Demaglio G (2004) Solitary fibrous tumor of the spinal cord: a clinicopathologic study of two cases. Ann Diagn Pathol 8(5):268–275

    Article  PubMed  Google Scholar 

  31. Vallat-Decouvelaere AV, Dry SM, Fletcher CDM (1998) Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22:1501–1511

    Article  PubMed  CAS  Google Scholar 

  32. Vorster SJ, Prayson RA, Lee JH (2000) Solitary fibrous tumor of the thoracic spine. Case report and review of the literature. J Neurosurg (Spine2) 92:217–220

    Article  CAS  Google Scholar 

  33. Witkin GB, Rosai J (1991) Solitary fibrous tumor of the upper respiratory tract. A report of six cases. Am J Surg Pathol 15:842–848

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors give special thanks to Toshiro Takatsu MD, PhD, Yutaka Nishimoto MD, PhD, Koji Mizoguchi MD, and Kazuichiro Ohnishi MD, PhD for their contributions to the diagnosis and treatment for the presented case.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan

    Koji Hashimoto, Kei Miyamoto, Hideo Hosoe, Gou Kawai, Kenta Kikuike, Naoki Suzuki, Hirotaka Kodama & Katsuji Shimizu

  2. Department of Lavoratory Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan

    Kuniyasu Shimokawa

  3. Department of Radiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan

    Masayuki Matsuo

  4. Department of Reconstructive Surgery for Bone and Joint, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 500-1194, Japan

    Kei Miyamoto

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  1. Koji Hashimoto
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  2. Kei Miyamoto
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  3. Hideo Hosoe
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Correspondence to Kei Miyamoto.

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Hashimoto, K., Miyamoto, K., Hosoe, H. et al. Solitary fibrous tumor in the cervical spine with destructive vertebral involvement: a case report and review of the literature. Arch Orthop Trauma Surg 128, 1111–1116 (2008). https://doi.org/10.1007/s00402-007-0529-y

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  • DOI: https://doi.org/10.1007/s00402-007-0529-y

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