Acta Neuropathologica

, Volume 135, Issue 3, pp 481–484 | Cite as

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC)

  • David N. Louis
  • Pieter Wesseling
  • Werner Paulus
  • Caterina Giannini
  • Tracy T. Batchelor
  • J. Gregory Cairncross
  • David Capper
  • Dominique Figarella-Branger
  • M. Beatriz Lopes
  • Wolfgang Wick
  • Martin van den Bent



This paper has been reviewed by the Steering Committee and Clinical Advisory Panel of cIMPACT-NOW [1, 2] and by the International Society of Neuropathology Executive.


  1. 1.
    Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D et al (2017) Announcing cIMPACT-NOW: the consortium to inform molecular and practical approaches to CNS tumor taxonomy. Acta Neuropathol 133:1–3. CrossRefPubMedGoogle Scholar
  2. 2.
    Louis DN, Aldape K, Brat DJ, Capper D, Ellison DW, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D et al (2017) cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification. Brain Pathol 27:851–852. CrossRefPubMedGoogle Scholar
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    Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2016) World Health Organization histological classification of tumours of the central nervous system. International Agency for Research on Cancer, LyonGoogle Scholar
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    Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820. CrossRefPubMedGoogle Scholar
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    ICD-10 (2016) International statistical classification of diseases and related health problems, 10th revision, vol 2. Instruction manual, Fifth edition. WHO, Geneva, p 26Google Scholar
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    Louis DN, Perry A, Burger P, Ellison DW, Reifenberger G, von Deimling A, Aldape K, Brat D, Collins VP, Eberhart C et al (2014) International Society Of Neuropathology-Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol 24:429–435. CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • David N. Louis
    • 1
  • Pieter Wesseling
    • 2
    • 3
    • 4
  • Werner Paulus
    • 5
  • Caterina Giannini
    • 6
  • Tracy T. Batchelor
    • 7
  • J. Gregory Cairncross
    • 8
  • David Capper
    • 9
    • 10
  • Dominique Figarella-Branger
    • 11
  • M. Beatriz Lopes
    • 12
  • Wolfgang Wick
    • 13
  • Martin van den Bent
    • 14
  1. 1.Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of PathologyVU University Medical CenterAmsterdamThe Netherlands
  3. 3.Department of PathologyPrincess Máxima Center for Pediatric OncologyUtrechtThe Netherlands
  4. 4.University Medical Center UtrechtUtrechtThe Netherlands
  5. 5.Institute of NeuropathologyUniversity Hospital MünsterMünsterGermany
  6. 6.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA
  7. 7.Departments of Neurology, Radiation Oncology and Division of Hematology/OncologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  8. 8.Charbonneau Cancer InstituteUniversity of CalgaryCalgaryCanada
  9. 9.Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu BerlinBerlinGermany
  10. 10.Department of NeuropathologyBerlin Institute of HealthBerlinGermany
  11. 11.Aix-Marseille Univ, APHM, Inserm, CRO2 UMR_S 911, Hôpital de la Timone, Service d’Anatomie Pathologique et de NeuropathologieMarseilleFrance
  12. 12.Departments of Pathology and Neurological SurgeryUniversity of VirginiaCharlottesvilleUSA
  13. 13.Neurology Clinic and National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK) Core Center HeidelbergHeidelbergGermany
  14. 14.The Brain Tumor Center at Erasmus MC Cancer CenterRotterdamThe Netherlands

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