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Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma

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Acknowledgments

We thank Silvia Occhionero, Judith Berkmüller, Veronika Kaltenbrunn and Michael Schmidt for technical support and Dr. Irmela Jeremias and Fabian Klein for help with FACS analyses. We thank Patricia Bonert, Heike Jäckle, Beate Jantz, Pitt Liebmann, Christine Mann and Michaela Wellisch for animal husbandry. Ctnnb1(ex3)Fl/Fl and GSK3β Fl/Fl mice were kindly provided by Dr. Taketo (University of Tokyo, Japan) and Dr. van Leuven (Department of Human Genetics, KU Leuven, Belgium). This work was supported by the Deutsche Krebshilfe, Wilhelm Sander Foundation (both to U.S.) and Friedrich-Baur-Foundation (to J.P.).

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Authors and Affiliations

  1. Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, 81377, Munich, Germany

    Julia Pöschl, Martin Bartels, Jasmin Ohli, Edoardo Bianchi, Konstantin Kuteykin-Teplyakov, Daniel Grammel, Julia Ahlfeld & Ulrich Schüller

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  1. Julia Pöschl
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  2. Martin Bartels
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  6. Daniel Grammel
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  7. Julia Ahlfeld
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  8. Ulrich Schüller
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Correspondence to Ulrich Schüller.

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Pöschl, J., Bartels, M., Ohli, J. et al. Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma. Acta Neuropathol 127, 605–607 (2014). https://doi.org/10.1007/s00401-014-1258-2

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  • DOI: https://doi.org/10.1007/s00401-014-1258-2

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