References
Elden AC, Kim HJ, Hart MP et al (2010) Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature 466:1069–1075
Lee T, Li YR, Ingre C et al (2011) Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients. Hum Mol Genet 20:1697–1700
Nishihira Y, Tan CF, Onodere O et al (2008) Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic and glial cytoplasmic inclusions. Acta Neuropathol 116:169–182
Schwab C, Arai T, Hasegawa M et al (2008) Colocalization of transactivation-responsive DNA-binding protein 43 and Huntington in inclusions of Huntington disease. J Neuropathol Exp Neurol 67:1159–1165
Seidel K, den Dunnen WFA, Schulz C et al (2010) Axonal inclusions in spinocerebellar ataxia type 3. Acta Neuropathol 120:449–460
Tan C-F, Yamada M, Toyoshima Y et al (2009) Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado–Joseph disease. Acta Neuropathol 118:553–560
Acknowledgments
This work was supported by Grants-in-Aid, 23590390 (to Y.T.), and 20240037 and 23240049 (to H.T.), for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
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Toyoshima, Y., Tanaka, H., Shimohata, M. et al. Spinocerebellar ataxia type 2 (SCA2) is associated with TDP-43 pathology. Acta Neuropathol 122, 375–378 (2011). https://doi.org/10.1007/s00401-011-0862-7
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DOI: https://doi.org/10.1007/s00401-011-0862-7