European Journal of Nutrition

, Volume 51, Supplement 2, pp 27–30 | Cite as

Functional foods/ingredients and periodontal diseases

  • Marja L. Laine
  • Wim Crielaard

Periodontal diseases are a collection of inflammatory processes that affect the periodontium, that is, the teeth supporting tissues. Gingivitis (infected red swollen and easily bleeding gums) is a mild reversible form of periodontal disease. Almost 100% of the population suffers from time to time from gingivitis. Gingivitis can develop into periodontitis, which is a chronic inflammatory disease of the supporting tissues of the teeth [34]. In conjunction with red, swollen gums that easily bleed as a result of the disease, teeth may show exposed root surfaces and often dental radiographs reveal periodontal (alveolar) bone loss around the teeth due to the inflammation process; teeth will become mobile and migrate and will eventually exfoliate.

Patients with periodontitis may have bad breath, suffer from important subjective and objective esthetic problems and experience problems with chewing due to tooth mobility and loss of teeth. Dental professionals provide labor-intensive treatment to...



This publication was commissioned by the Functional Foods Task Force of the European branch of the International Life Sciences Institute (ILSI Europe). Industry members of the task force are Abbott Nutrition, Barilla G. & R. Fratelli, BASF, Bionov, Biosearch Life, Cargill, Chiquita Brands International, Coca-Cola Europe, Danone, Dow Europe, DSM, DuPont Nutrition & Health, Institut Mérieux, International Nutrition Company, Kellogg Europe, Kraft Foods Europe, Mars, Martek Biosciences Corporation, McNeil Nutritionals, Naturex, Nestlé, PepsiCo International, Pfizer Consumer Healthcare, Red Bull, Rudolf Wild, Schwabegroup, Royal FrieslandCampina, Soremartec Italia—Ferrero Group, Südzucker/BENEO Group, Tate & Lyle Ingredients, Tereos-Syral, Unilever and Yakult Europe. This publication was coordinated by Dr. Alessandro Chiodini, Scientific Project Manager at ILSI Europe. For further information about ILSI Europe, please email or call +32 2 771 00 14. The opinions expressed herein and the conclusions of this publication are those of the authors and do not necessarily represent the views of ILSI Europe nor those of its member companies.

Declaration of interest

W. Crielaard and M. L. Laine received a honorarium from ILSI Europe for their participation in this publication and reimbursement of their travel and accommodation costs for attending the related meetings.


  1. 1.
    Al-Zahrani MS (2006) Increased intake of dairy products is related to lower periodontitis prevalence. J Periodontol 77:289–294CrossRefGoogle Scholar
  2. 2.
    Al-Zahrani MS, Borawski EA, Bissada NF (2005) Periodontitis and three health-enhancing behaviors: maintaining normal weight, engaging in recommended level of exercise, and consuming a high-quality diet. J Periodontol 76:1362–1366CrossRefGoogle Scholar
  3. 3.
    Berglundh T, Donati M, Hahn-Zoric M, Hanson LA, Padyukov L (2003) Association of the -1087 IL 10 gene polymorphism with severe chronic periodontitis in Swedish Caucasians. J Clin Periodontol 30:249–254CrossRefGoogle Scholar
  4. 4.
    Bodet C, Grenier D, Chandad F, Ofek I, Steinberg D, Weiss EI (2008) Potential oral health benefits of cranberry. Crit Rev Food Sci Nutr 48:672–680CrossRefGoogle Scholar
  5. 5.
    Boström L, Bergström J, Dahlén G, Linder LE (2001) Smoking and subgingival microflora in periodontal disease. J Clin Periodontol 28:212–219CrossRefGoogle Scholar
  6. 6.
    Bouclin R, Landry RG, Noreau G (1997) The effects of smoking on periodontal structures: a literature review. J Can Dent Assoc 63(356):360–363Google Scholar
  7. 7.
    Boughman JA, Stick MJ, Peterson DA, Cohen MM (1992) Linkage analysis and predicting genetic disease. Clin Lab Med 12:449–461Google Scholar
  8. 8.
    Breivik T, Thrane PS, Murison R, Gjermo P (1996) Emotional stress effects on immunity, gingivitis and periodontitis. Eur J Oral Sci 104:327–334CrossRefGoogle Scholar
  9. 9.
    Brown LJ, Oliver RC, Loe H (1990) Evaluating periodontal status of US employed adults. J Am Dent Assoc 121:226–232Google Scholar
  10. 10.
    Chapple IL (2009) Potential mechanisms underpinning the nutritional modulation of periodontal inflammation. J Am Dent Assoc 140:178–188Google Scholar
  11. 11.
    Chen C (2001) Periodontitis as a biofilm infection. J Calif Dent Assoc 29:362–369Google Scholar
  12. 12.
    de Brito Júnior RB, Scarel-Caminaga RM, Trevilatto PC, de Souza AP, Barros SP (2004) Polymorphisms in the vitamin D receptor gene are associated with periodontal disease. J Periodontol 75:1090–1095CrossRefGoogle Scholar
  13. 13.
    Gonzales JR, Michel J, Diete A, Herrmann JM, Bödeker RH, Meyle J (2002) Analysis of genetic polymorphisms at the interleukin-10 loci in aggressive and chronic periodontitis. J Clin Periodontol 29:816–822CrossRefGoogle Scholar
  14. 14.
    Graswinckel JE, van der Velden U, van Winkelhoff AJ, Hoek FJ, Loos BG (2004) Plasma antibody levels in periodontitis patients and controls. J Clin Periodontol 31:562–568CrossRefGoogle Scholar
  15. 15.
    Hosokawa Y, Hosokawa I, Ozaki K, Nakanishi T, Nakae H, Matsuo T (2009) Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts. J Nutr Biochem Jul 17 [Epub ahead of print]Google Scholar
  16. 16.
    Kushiyama M, Shimazaki Y, Murakami M, Yamashita Y (2009) Relationship between intake of green tea and periodontal disease. J Periodontol 80:372–377CrossRefGoogle Scholar
  17. 17.
    Krahwinkel T, Willershausen B (2000) The effect of sugar-free green tea chew candies on the degree of inflammation of the gingival. Eur J Med Res 30:463–467Google Scholar
  18. 18.
    Krasse P, Carlsson B, Dahl C, Paulsson A, Nilsson A, Sinkiewicz G (2006) Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri. Swed Dent J 30:55–60Google Scholar
  19. 19.
    Laine ML, Farré MA, González G, van Dijk LJ, Ham AJ, Winkel EG, Crusius JB, Vandenbroucke JP, van Winkelhoff AJ, Peña AS (2001) Polymorphisms of the interleukin-1 gene family, oral microbial pathogens, and smoking in adult periodontitis. J Dent Res 80:1695–1699CrossRefGoogle Scholar
  20. 20.
    Laine ML, Loos BG, Crielaard W (2010) Gene polymorphisms in chronic periodontitis. Int J Dent 2010:324719Google Scholar
  21. 21.
    Lauten JD, Boyd L, Hanson MB, Lillie D, Gullion C, Madden TE (2005) A clinical study: Melaleuca, Manuka, Calendula and green tea mouth rinse. Phytother Res 19:951–957CrossRefGoogle Scholar
  22. 22.
    Laxman VK, Annaji S (2008) Tobacco use and its effects on the periodontium and periodontal therapy. J Contemp Dent Pract 9:97–107Google Scholar
  23. 23.
    Loos BG (2006) Systemic effects of periodontitis. Ann R Australas Coll Dent Surg 18:27–29Google Scholar
  24. 24.
    Loos BG, John RP, Laine ML (2005) Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodontol 32:159–179CrossRefGoogle Scholar
  25. 25.
    Loos BG, Leppers-Van de Straat FG, Van de Winkel JG, Van der Velden U (2003) Fcgamma receptor polymorphisms in relation to periodontitis. J Clin Periodontol 30:595–602CrossRefGoogle Scholar
  26. 26.
    Matuliene G, Pjetursson BE, Salvi GE, Schmidlin K, Brägger U, Zwahlen M, Lang NP (2008) Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance. J Clin Periodontol 35:685–695CrossRefGoogle Scholar
  27. 27.
    Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y, Shimauchi H (2009) Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 36:506–513CrossRefGoogle Scholar
  28. 28.
    Meisel P, Carlsson LE, Sawaf H, Fanghaenel J, Greinacher A, Kocher T (2001) Polymorphisms of Fc gamma-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontal diseases. Genes Immun 2:258–262CrossRefGoogle Scholar
  29. 29.
    Meurman JH, Stamatova I (2007) Probiotics: contributions to oral health. Oral Dis 13:443–451CrossRefGoogle Scholar
  30. 30.
    Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, Califano JV, Burmeister JA, Schenkein HA (2000) J Periodontol 71:1699–1707CrossRefGoogle Scholar
  31. 31.
    Michalowicz BS, Aeppli D, Virag JG, Klump DG, Hinrichs JE, Segal NL, Bouchard TJ Jr, Pihlstrom BL (1991) Periodontal findings in adult twins. J Periodontol 62:293–299CrossRefGoogle Scholar
  32. 32.
    Nakamura H, Ukai T, Yoshimura A, Kozuka Y, Yoshioka H, Yoshinaga Y, Abe Y, Hara Y (2009) Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo. J Periodontal Res Jul 8 [Epub ahead of print]Google Scholar
  33. 33.
    Petti S, Scully C (2009) Polyphenols, oral health and disease: a review. J Dent Res 37:413–423CrossRefGoogle Scholar
  34. 34.
    Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366:1809–1820CrossRefGoogle Scholar
  35. 35.
    Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, Camargo LE, Line SR (2004) Interleukin 10 gene promoter polymorphisms are associated with chronic periodontitis. J Clin Periodontol 31:443–448CrossRefGoogle Scholar
  36. 36.
    Schifferle RE (2009) Periodontal disease and nutrition: separating the evidence from current fads. Periodontol 2000(50):78–89CrossRefGoogle Scholar
  37. 37.
    Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H (2008) Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. J Clin Periodontol 35:897–905CrossRefGoogle Scholar
  38. 38.
    Shimazaki Y, Shirota T, Uchida K, Yonemoto K, Kiyohara Y, Iida M, Saito T, Yamashita Y (2008) Intake of dairy products and periodontal disease: the Hisayama study. J Periodontol 79:131–137CrossRefGoogle Scholar
  39. 39.
    Socransky SS, Haffajee AD (2005) Periodontal microbial ecology. Periodontol 2000(38):135–187CrossRefGoogle Scholar
  40. 40.
    Sun JL, Meng HX, Cao CF, Tachi Y, Shinohara M, Ueda M, Imai H, Ohura K (2002) Relationship between vitamin D receptor gene polymorphism and periodontitis. J Periodontal Res 37:263–267CrossRefGoogle Scholar
  41. 41.
    Twetman S, Derawi B, Keller M, Ekstrand K, Yucel-Lindberg T, Stecksen-Blicks C (2009) Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid. Acta Odontol Scand 67:19–24CrossRefGoogle Scholar
  42. 42.
    Van der Velden U (2000) Diagnosis of periodontitis. J Clin Periodontol 27:960–961CrossRefGoogle Scholar
  43. 43.
    Van der Velden U, Abbas F, Armand S, de Graaff J, Timmerman MF, van der Weijden GA, van Winkelhoff AJ, Winkel EG (1993) The effect of sibling relationship on the periodontal condition. J Clin Periodontol 20:683–690CrossRefGoogle Scholar
  44. 44.
    Van Winkelhoff AJ, Bosch-Tijhof CJ, Winkel EG, van der Reijden WA (2001) Smoking affects the subgingival microflora in periodontitis. J Periodontol 72:666–671CrossRefGoogle Scholar
  45. 45.
    Van Winkelhoff AJ, Loos BG, van der Reijden WA, van der Velden U (2002) Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J Clin Periodontol 29:1023–1028CrossRefGoogle Scholar
  46. 46.
    Williams RC, Barnett AH, Claffey N, Davis M, Gadsby R, Kellett M, Lip GY, Thackray S (2009) The potential impact of periodontal disease on general health: a consensus view. Curr Med Res Opin 24:1635–1643CrossRefGoogle Scholar
  47. 47.
    Yamamoto K, Kobayashi T, Grossi S, Ho AW, Genco RJ, Yoshie H, De Nardin E (2004) Association of Fcgamma receptor IIa genotype with chronic periodontitis in Caucasians. J Periodontol 75:517–522CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Marja L. Laine
    • 1
  • Wim Crielaard
    • 1
  1. 1.Academic Centre for Dentistry AmsterdamAmsterdamThe Netherlands

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