Zeitschrift für Rheumatologie

, Volume 76, Issue 2, pp 176–182 | Cite as

Association between BLK polymorphisms and susceptibility to SLE

A meta-analysis
  • G. G. Song
  • Y. H. Lee



This study aimed to explore whether B‑cell lymphocyte kinase (BLK) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE) in ethnically diverse populations.


We conducted a meta-analysis of the association between the BLK rs13277113 A/G, rs2736340 T/C, rs2248932 T/C, and rs2618476 G/A polymorphisms and SLE.


Seventeen studies with 22,701 patients and 36,365 controls were included in the meta-analysis. The meta-analysis revealed a significant association between SLE and the BLK rs13277113 A allele (OR = 1.359, 95 % CI = 1.292–1.429, p < 1.0 × 10−8), and stratification by ethnicity indicated an association between this allele and SLE in Caucasians, Asians, and Africans (OR = 1.315, 95 % CI = 1.252–1.380, p < 1.0 × 10−8; OR = 1.415, 95 % CI = 1.287–1.555, p < 1.0 × 10−8; OR = 1.361, 95 % CI = 1.194–1.550, p = 3.6 × 10−6). A significant association between SLE and the rs2736340 T allele (OR = 1.354, 95 % CI = 1.286–1.426, p < 1.0 × 10−8) was also observed, and stratification by ethnicity indicated an association between the risk allele and SLE in Caucasians and Asians (OR = 1.333, 95 % CI = 1.259–1.412, p < 1.0 × 10−8; OR = 1.525, 95 % CI = 1.339–1.736, p < 1.0 × 10−8). Meta-analysis also revealed a significant association between SLE and the BLK alleles rs2248932 T and rs2618476 G (OR = 1.285 95 % CI = 1.228–1.345, p < 1.0 × 10−8; OR = 1.374, 95 % CI = 1.294–1.468, p < 1.0 × 10−8), and stratification by ethnicity indicated an association between these alleles and SLE in Caucasians and Asians.


This meta-analysis confirms that polymorphisms in the BLK alleles rs13277113 A/G, rs2736340 T/C, and rs2248932 T/C are associated with susceptibility to SLE in Caucasian and Asian populations.


SLE BLK Polymorphism Meta-analysis 

Zusammenhang zwischen BLK-Polymorphismus und Anfälligkeit für SLE

Eine Metaanalyse



Ziel dieser Studie war es, in ethnisch verschiedenen Populationen herauszufinden, ob Polymorphismen der B‑lymphozitären Kinase (BLK) mit Anfälligkeit für systemische Lupus erythematodes (SLE) in Zusammenhang stehen.


Es wurde eine Metaanalyse des Zusammenhangs zwischen den BLK-Polymorphismen rs13277113 A/G, rs2736340 T/C, rs2248932 T/C und rs2618476 G/A sowie SLE durchgeführt.


17 Studien mit 22.701 Patienten und 36.365 Kontrollpersonen wurden in die Metaanalyse einbezogen. Die Metaanalyse zeigte einen signifikanten Zusammenhang zwischen SLE und dem Allel BLK rs13277113 A (OR = 1,359, 95 % CI = 1,292–1,429, p < 1,0 × 10 8) und die Stratifizierung nach Ethnie wies auf einen Zusammenhang zwischen diesem Allel und SLE bei Menschen aus Europa, Asien und Afrika hin (OR = 1,315, 95 % CI = 1,252–1,380, p < 1,0 × 10 8; OR = 1,415, 95 % CI = 1,287–1,555, p < 1,0 × 10 8; OR = 1,361, 95 % CI = 1,194–1,550, p = 3,6 × 10 6). Ebenfalls beobachtet wurde ein signifikanter Zusammenhang zwischen SLE und Allel rs2736340 T (OR = 1,354, 95 % CI = 1,286–1,426, p < 1,0 × 10 8) und die Stratifizierung nach Ethnie deutete auf einen Zusammenhang zwischen diesem Risiko-Allel und SLE bei Menschen aus Europa und Asien hin (OR = 1,333, 95 % CI = 1,259–1,412, p < 1,0 × 10 8; OR = 1,525, 95 % CI = 1,339–1,736, p < 1,0 × 10 8). Die Metaanalyse zeigte auch einen signifikanten Zusammenhang zwischen SLE und den BLK-Allelen rs2248932 T und rs2618476 G (OR = 1,285 95 % CI = 1228–1,345, p < 1.0 × 10 8; OR = 1,374, 95 % CI = 1,294–1,468, p < 1,0 × 10 8). Die Stratifizierung nach Ethnie wies auf einen Zusammenhang zwischen diesen Allelen und SLE bei Menschen aus Europa und Asien hin.


Diese Metaanalyse bestätigt, dass Polymorphismen in den BLK-Allelen rs13277113 A/G, rs2736340 T/C und rs2248932 T/C mit Anfälligkeit für SLE in der weißen und asiatischen Bevölkerung in Zusammenhang stehen.


SLE BLK Polymorphismus Metaanalyse 



This study was supported by a Korea University grant.

Compliance with ethical guidelines

Conflict of interest

G. G. Song and Y. H. Lee state that there are no conflicts of interest.

The accompanying manuscript does not include studies on humans or animals.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of Internal Medicine, Korea University Anam HospitalKorea University College of MedicineSeoulKorea

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