Advertisement

Clinical Research in Cardiology

, Volume 107, Issue 11, pp 1084–1085 | Cite as

Reply to the letter “Cardiac autonomic evaluation in breast cancer patients: role of cytokines and heart rate recovery”

  • Claudia Arab
  • Luiz Carlos Marques Vanderlei
  • Yori Gidron
  • Celso Ferreira
Letter to the Editors
  • 120 Downloads

Sirs:

We received a letter about our recently published article. Okutucu et al. have suggested certain evaluations for future investigations. The suggestions were about assessments of cardiac autonomic modulation, cytokines and heart rate recovery (HRR) in breast cancer patients. We agree with the authors and are thankful for the suggestions. Our responses to these suggestions are given in the following.

We agree with the authors and consider that investigating the relationship between breast cancer staging, cardiac autonomic modulation and inflammation is promising. In our article, we also discussed our result (i.e., lower vagal modulation in advanced breast cancer patients compared to early-stages) and we proposed that this could be due to the neuroimmunomodulatory role of the vagus nerve in cancer [1]. Cancer tumors progress under the influence of inflammation [2]. Animal model studies have shown interesting relationships between vagal modulation, inflammation and tumor...

References

  1. 1.
    Gidron Y, Perry H, Glennie M (2005) Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncol 6:245–248.  https://doi.org/10.1016/S1470-2045(05)70096-6 CrossRefPubMedGoogle Scholar
  2. 2.
    Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436–444.  https://doi.org/10.1038/nature07205 CrossRefGoogle Scholar
  3. 3.
    Partecke LI, Käding A, Trung DN, Diedrich S, Sendler M, Weiss F, Kühn JP, Mayerle J, Beyer K, von Bernstorff W, Heidecke CD, Keßler W (2017) Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFa in a murine pancreatic cancer model. Oncotarget 8:22501–22502.  https://doi.org/10.18632/oncotarget.15019 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    DeNardo DG, Coussens LM (2007) Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res 9:212CrossRefGoogle Scholar
  5. 5.
    De Couck M, Maréchal R, Moorthamers S, Van Laethem J-L, Gidron Y (2016) Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation. Cancer Epidemiol 40:47–51.  https://doi.org/10.1016/j.canep.2015.11.007 CrossRefPubMedGoogle Scholar
  6. 6.
    [Gidron Y, De Couck M, Schallier D, De Greve J, Van Laethem J, Maréchal R (2018) The relationship between a new biomarker of vagal neuroimmunomodulation and survival in two fatal cancers. J Immunol Res 2018:4874193.  https://doi.org/10.1155/2018/4874193 CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Pierce BL, Ballard-Barbash R, Bernstein L, Baumgartner RN, Neuhouser ML, Wener MH, Baumgartner KB, Gilliland FD, Sorensen BE, McTiernan A, Ulrich CM (2009) Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol 27:3437–3444.  https://doi.org/10.1200/JCO.2008.18.9068 CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Peçanha T, Silva-Júnior ND, Forjaz LCdM (2014) Heart rate recovery: autonomic determinants, methods of assessment and association with mortality and cardiovascular diseases. Clin Physiol Funct Imaging 34:327–339.  https://doi.org/10.1111/cpf.12102 CrossRefPubMedGoogle Scholar
  9. 9.
    Ng J, Sundaram S, Kadish AH, Goldberger JJ (2009) Autonomic effects on the spectral analysis of heart rate variability after exercise. Am J Physiol Heart Circ Physiol 297:H1421-H1428.  https://doi.org/10.1152/ajpheart.00217.2009 CrossRefPubMedCentralGoogle Scholar
  10. 10.
    Goldberger JJ, Le FK, Lahiri M, Kannankeril PJ, Ng J, Kadish AH (2006) Assessment of parasympathetic reactivation after exercise. Am J Physiol Heart Circ Physiol 290:H2446-H2452CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018
corrected publication July 2018

Authors and Affiliations

  1. 1.Departamento de Medicina, Disciplina de Cardiologia, Hospital São Paulo, Escola Paulista de MedicinaUniversidade Federal de São PauloSao PauloBrazil
  2. 2.Departamento de Fisioterapia, Faculdade de Ciência e TecnologiaUniversidade do Estado de São PauloPresidente PrudenteBrazil
  3. 3.Free University of Brussels (VUB)IxellesBelgium

Personalised recommendations