Skip to main content
Log in

Fistulectomy and endorectal advancement flap repair for cryptoglandular anal fistula: recurrence and functional outcome over 10 years of follow-up

  • Original Article
  • Published:
International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

To examine long-term recurrence and anal continence of patients with anal fistula treated by fistulectomy and endorectal advancement flap repair.

Method

Retrospective analysis of a prospective cohort of 115 patients (77.4% males, mean age 48.9 years) requiring 130 procedures, with a minimum follow-up of 10 years. Recurrence included reappearance of fistula after wound healing or presence of an abscess or chronic suppuration in the operated area at follow-up. Fecal incontinence was evaluated by the Cleveland Clinic Florida (CCF-FI) fecal incontinence scoring system.

Results

The mean and SD duration of the follow-up period was 155.5 (21.7) months. Recurrence developed in 31 (23.8%) cases, 28 (90.3%) of which within the first year, with a mean time to recurrence of 4.9 (2.9) months. The success rate was 76.2%. Anal continence was normal in 80% of patients before surgery, 63.8% at 1-year follow-up, and 71.5% at the end of follow-up (p < 0.001). Overall, continence worsened in 16.9% of cases. The mean (95% CI) CCF-FI score was 0.78 (0.35–1.21) preoperatively, 1.04 (0.64–1.43) at 1 year after surgery, 0.90 (0.52–1.29) at 5 years, and 1.16 (0.66–1.67) at the end of the study (p < 0.05). Neither recurrence nor continence was significantly associated with previous anal or fistula surgical procedures or complexity of the fistula.

Conclusion

In this study, fistulectomy and endorectal advancement flap repair was associated with a long-term high rate of success. Most recurrences occurred within the first year and continence showed a mild deterioration over time.

Clinical trial registration: Not applicable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hokkanen SR, Boxall N, Khalid JM, Bennett D, Patel H (2019) Prevalence of anal fistula in the United Kingdom. World J Clin Cases 7:1795–1804. https://doi.org/10.12998/wjcc.v7.i14.1795

    Article  PubMed  PubMed Central  Google Scholar 

  2. Malik AI, Nelson RL (2008) Surgical management of anal fistulae: a systematic review. Colorectal Dis 10:420–430. https://doi.org/10.1111/j.1463-1318.2008.01483.x

    Article  CAS  PubMed  Google Scholar 

  3. Jacob TJ, Perakath B, Keighley MR (2010) Surgical intervention for anorectal fistula. Cochrane Database Syst Rev 5:CD006319. https://doi.org/10.1002/14651858.CD006319.pub2

    Article  Google Scholar 

  4. Soltani A, Kaiser AM (2010) Endorectal advancement flap for cryptoglandular or Crohn's fistula-in-ano. Dis Colon Rectum 53:486–495. https://doi.org/10.1007/DCR.0b013e3181ce8b01

    Article  PubMed  Google Scholar 

  5. Kronborg O (1985) To lay open or excise a fistula-in-ano: a randomized trial. Br J Surg 172:970. https://doi.org/10.1002/bjs.1800721211

    Article  Google Scholar 

  6. Mizrahi N, Wexner SD, Zmora O, Da Silva G, Efron J, Weiss EG, Vernava AM 3rd, Nogueras JJ (2002) Endorectal advancement flap: are there predictors of failure? Dis Colon Rectum 45:1616–1621. https://doi.org/10.1097/01.DCR.0000037654.01119.CD

    Article  PubMed  Google Scholar 

  7. Perez F, Arroyo A, Serrano P, Sánchez A, Candela F, Perez MT, Calpena R (2006) Randomized clinical and manometric study of advancement flap versus fistulotomy with sphincter reconstruction in the management of complex fistula-in-ano. Am J Surg 192:34–40. https://doi.org/10.1016/j.amjsurg.2006.01.028

    Article  PubMed  Google Scholar 

  8. van der Hagen SJ, Baeten CG, Soeters PB, van Gemert WG (2006) Long-term outcome following mucosal advancement flap for high perianal fistulas and fistulotomy for low perianal fistulas: recurrent perianal fistulas: failure of treatment or recurrent patient disease? Int J Colorectal Dis 21:784–790. https://doi.org/10.1007/s00384-005-0072-7

    Article  PubMed  Google Scholar 

  9. Mitalas LE, Gosselink MP, Oom DM, Zimmerman DD, Schouten WR (2009) Required length of follow-up after transanal advancement flap repair of high transsphincteric fistulas. Colorectal Dis 11:726–728. https://doi.org/10.1111/j.1463-1318.2008.01666.x

    Article  CAS  PubMed  Google Scholar 

  10. Jarrar A, Church J (2011) Advancement flap repair: a good option for complex anorectal fistulas. Dis Colon Rectum 54:1537–1541. https://doi.org/10.1097/DCR.0b013e31822d7ddd

    Article  PubMed  Google Scholar 

  11. Lee CL, Lu J, Lim TZ, Koh FH, Lieske B, Cheong WK, Tan KK (2015) Long-term outcome following advancement flaps for high anal fistulas in an Asian population: a single institution's experience. Int J Colorectal Dis 30:409–412. https://doi.org/10.1007/s00384-014-2100-y

    Article  PubMed  Google Scholar 

  12. Parks AG, Gordon PH, Hardcastle JD (1976) A classification of fistula-in-ano. Br J Surg 63:1–12. https://doi.org/10.1002/bjs.1800630102

    Article  CAS  PubMed  Google Scholar 

  13. Ortíz H, Marzo J (2000) Endorectal flap advancement repair and fistulectomy for high trans-sphincteric and suprasphincteric fistulas. Br J Surg 87:1680–1683. https://doi.org/10.1046/j.1365-2168.2000.01582.x

    Article  PubMed  Google Scholar 

  14. Jorge JM (1993) Wexner SD (1993) Etiology and management of fecal incontinence. Dis Colon Rectum 36:77–97. https://doi.org/10.1007/BF02050307

    Article  CAS  PubMed  Google Scholar 

  15. Tan KK, Alsuwaigh R, Tan AM, Tan IJ, Liu X, Koh DC, Tsang CB (2012) To LIFT or to flap? Which surgery to perform following seton insertion for high anal fistula? Dis Colon Rectum 55:1273–1277. https://doi.org/10.1097/DCR.0b013e31826dbff0

    Article  PubMed  Google Scholar 

  16. Stellingwerf ME, van Praag EM, Tozer PJ, Bemelman WA, Buskens CJ (2019) Systematic review and meta-analysis of endorectal advancement flap and ligation of the intersphincteric fistula tract for cryptoglandular and Crohn's high perianal fistulas. BJS Open 21:231–241. https://doi.org/10.1002/bjs5.50129

    Article  Google Scholar 

  17. Ozuner G, Hull TL, Cartmill J, Fazio VW (1996) Long-term analysis of the use of transanal rectal advancement flaps for complicated anorectal/vaginal fistulas. Dis Colon Rectum 39:10–14. https://doi.org/10.1007/BF02048261

    Article  CAS  PubMed  Google Scholar 

  18. van Koperen PJ, Wind J, Bemelman WA, Bakx R, Reitsma JB, Slors JF (2008) Long-term functional outcome and risk factors for recurrence after surgical treatment for low and high perianal fistulas of cryptoglandular origin. Dis Colon Rectum 51:1475–1481. https://doi.org/10.1007/s10350-008-9354-9

    Article  PubMed  Google Scholar 

  19. Aguilar PS, Plasencia G, Hardy TG Jr, Hartmann RF, Stewart WR (1985) Mucosal advancement in the treatment of anal fistula. Dis Colon Rectum 28:496–498. https://doi.org/10.1007/BF02554093

    Article  CAS  PubMed  Google Scholar 

  20. Golub RW, Wise WE Jr, Kerner BA, Khanduja KS, Aguilar PS (1997) Endorectal mucosal advancement flap: the preferred method for complex cryptoglandular fistula-in-ano. J Gastrointest Surg 1:487–491. https://doi.org/10.1016/s1091-255x(97)80138-2

    Article  CAS  PubMed  Google Scholar 

  21. Zimmerman DD, Delemarre JB, Gosselink MP, Hop WC, Briel JW, Schouten WR (2003) Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas. Br J Surg 90:351–354. https://doi.org/10.1002/bjs.4044

    Article  CAS  PubMed  Google Scholar 

  22. van Onkelen RS, Gosselink MP, van Rosmalen J, Thijsse S, Schouten WR (2014) Different characteristics of high and low transsphincteric fistulae. Colorectal Dis 16:471–475. https://doi.org/10.1111/codi.12578

    Article  PubMed  Google Scholar 

  23. Ortiz H, Marzo M, de Miguel M, Ciga MA, Oteiza F, Armendariz P (2008) Length of follow-up after fistulotomy and fistulectomy associated with endorectal advancement flap repair for fistula in ano. Br J Surg 95:484–487. https://doi.org/10.1002/bjs.6023

    Article  CAS  PubMed  Google Scholar 

  24. Uribe N, Millán M, Minguez M, Ballester C, Asencio F, Sanchiz V, Esclapez P, del Castillo JR (2007) Clinical and manometric results of endorectal advancement flaps for complex anal fistula. Int J Colorectal Dis 22:259–264. https://doi.org/10.1007/s00384-006-0172-z

    Article  PubMed  Google Scholar 

  25. Ellis CN, Clark S (2007) Effect of tobacco smoking on advancement flap repair of complex anal fistulas. Dis Colon Rectum 50:459–463. https://doi.org/10.1007/s10350-006-0829-2

    Article  PubMed  Google Scholar 

  26. Schouten WR, Zimmerman DD, Briel JW (1999) Transanal advancement flap repair of transsphincteric fistulas. Dis Colon Rectum 42:1419–1422. https://doi.org/10.1007/BF02235039

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank Dr Marta Pulido for editing the manuscript and editorial assistance.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carlos Chaveli Diaz.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval statement

The study was approved by the Institutional Review Board of Complejo Hospitalario de Navarra, Spain.

Patient consent statement

Written informed consent was obtained from all participants.

Permission to reproduce material from other sources

Not applicable.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chaveli Diaz, C., Esquiroz Lizaur, I., Marzo Virto, J. et al. Fistulectomy and endorectal advancement flap repair for cryptoglandular anal fistula: recurrence and functional outcome over 10 years of follow-up. Int J Colorectal Dis 36, 841–846 (2021). https://doi.org/10.1007/s00384-021-03867-0

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00384-021-03867-0

Keywords

Navigation