Prognosis after peritoneal metastases in colorectal cancer is worse than that after lung or liver metastases. Previously, we demonstrated the safety of intraperitoneal (ip) administration of paclitaxel (PTX) combined with mFOLFOX6/CapeOX plus bevacizumab for colorectal cancer with peritoneal metastasis in a phase-I trial. Here, we evaluated the efficacy of this chemotherapy.
We enrolled six patients with histologically confirmed peritoneal metastases secondary to colorectal cancer. PTX was administered through a peritoneal access port, in combination with oxaliplatin-based systematic chemotherapy. Response rate, progression-free survival, 1-year survival rate, frequency of improvement in peritoneal cancer index (PCI), and cytology in peritoneal lavage were evaluated. This study was registered in the University Hospital Medical Information Network Clinical Trial Registry on July 1, 2016 (UNIN000022924).
Three patients received the mFOLFOX6–bevacizumab regimen, whereas the other three received the CapeOX–bevacizumab regimen. The response rate was 25%. PCI score improved in 50% of the cases. Peritoneal lavage cytology that was positive in five patients before initiating the chemotherapy turned negative during chemotherapy in all patients. One-year survival rate was 100%, progression-free survival was 8.8 months (range, 6.8–12 months), and median survival time was 29.3 months.
The ip administration of PTX with systemic chemotherapy can potentially control peritoneal metastases in colorectal cancer.
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This study is supported by Grants-in-Aid for Scientific Research (C: grant number 18K07194, C: grant number 19K09114, C: grant number 19K09115) from the Japan Society for the Promotion of Science.
Conflict of interest
K. Muro is on the advisory board meeting for Bristol-Myers Squibb and Nippon Kayaku Co, Ltd.
This study was approved by the ethics committee of the University of Tokyo (P2015038-11X).
Statement of informed consent
Written informed consent was obtained from all patients.
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Murono, K., Nozawa, H., Nagata, H. et al. Efficacy of intraperitoneally administered paclitaxel for colorectal cancer with peritoneal metastases. Int J Colorectal Dis 35, 1945–1949 (2020). https://doi.org/10.1007/s00384-020-03649-0
- Phase 1 trial
- Intraperitoneal administration of paclitaxel
- Colorectal cancer
- Peritoneal metastases