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Oncological outcome of peripartum colorectal carcinoma—a single-center experience

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Objectives

This study aimed to analyze disease presentation, management, and oncological outcomes of patients diagnosed with peripartum colorectal cancer (CRC).

Methods

Retrospective cohort study of all consecutive women of childbearing age (18–45 years) between 2002 and 2014 diagnosed with CRC adenocarcinoma at a tertiary academic institution. Patients who experienced pregnancy within 12 months of their diagnosis (peripartum period, group 1) were compared to the remaining patients of the cohort (group 2). Overall survival (OS) was compared between the two groups through Kaplan-Meier estimates.

Results

Out of 555 consecutive women with a mean age of 37.8 + 6 years, 31 (5.6%) were diagnosed with CRC in the peripartum period. Of these, all patients were symptomatic during pregnancy due to bleeding, abdominal pain, or constipation; however, only 11 CRC (35.5%) were diagnosed during pregnancy, 1 (3.2%) during C section, and the remaining (61.3%) postpartum. TNM stage at presentation was I in 6 patients (19.4%), II in 4 patients (13.9%), III in 8 patients (25.8%), and IV in 13 patients (41.9%). Surgical resection was performed in 23 patients (74.2%): 2 while pregnant, 2 at the time of C section, and the remainder postpartum. Across all stages, OS was 95% at 1 year and 62% at 5 years and did not differ between the two comparative groups (p = 0.16).

Conclusions

A suspicious attitude towards cancer-related symptoms during pregnancy is crucial to prevent delayed evaluation for CRC.

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Acknowledgments

Fabian Grass was supported by the Société Académique Vaudoise, Lausanne, Switzerland, and by the SICPA Foundation, Lausanne, Switzerland.

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Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Assistant Professor of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Fabian Grass, Blake A. Spindler, Nimesh D. Naik, Cornelius A. Thiels, David W. Larson & Kellie L. Mathis

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  1. Fabian Grass
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  2. Blake A. Spindler
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  3. Nimesh D. Naik
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  4. Cornelius A. Thiels
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  5. Eric J. Dozois
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  6. David W. Larson
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  7. Kellie L. Mathis
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Correspondence to Kellie L. Mathis.

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Grass, F., Spindler, B.A., Naik, N.D. et al. Oncological outcome of peripartum colorectal carcinoma—a single-center experience. Int J Colorectal Dis 34, 899–904 (2019). https://doi.org/10.1007/s00384-019-03278-2

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  • DOI: https://doi.org/10.1007/s00384-019-03278-2

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