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Does enhanced recovery improve the survival rates of patients 3 years after undergoing surgery to remove a tumor in the colon?

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

The advantages of enhanced recovery programs (ERP) after colorectal surgery for morbidity and length of stay are well known. On a longer term, evidence is much more limited. The aim of this study is to determine the impact of ERP on survival after 3 years of follow-up, following colorectal cancer surgery.

Methods

All the patients undergoing resection for colorectal cancer between the years 2010 and 2014 were included. Patients were classified according to their compliance with the ERP (< 70 or ≥ 70%).

Results

Among the 206 patients included during the period, 129 were male (62.6%). The 3-year overall survival rate was 70.4% (145 patients) and relapse-free survival was 59.2% (122 patients). The survival after 3 years was influenced by the initial metastatic status (p < 0.0001), operative morbidity (p < 0.001), and the presence of peritumoral emboli (p = 0.006). However, the compliance with the ERP ≥ 70% did not influence overall survival (p = 0.63), nor relapse-free survival (p = 0.93). The same observations were found among the “at-risk” population (synchronous metastasis and postoperative complication).

Conclusion

The ERP does not seem to influence the 3-year relapse-free survival after colorectal resection for cancer.

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Authors and Affiliations

  1. Department of Visceral and Endocrinal Surgery, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France

    P. Viannay, A. Hamy, R. Jaouen & Aurélien Venara

  2. Département de Médecine, UFR Santé d’Angers, Angers, France

    P. Viannay, A. Hamy, R. Jaouen, F. X. Caroli-Bosc, C. Luel, S. Vasseur, J. F. Hamel & Aurélien Venara

  3. EA HIFIH, Angers, France

    A. Hamy, F. X. Caroli-Bosc & Aurélien Venara

  4. Department of Digestive and Liver Disease, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France

    F. X. Caroli-Bosc

  5. Department of Biostatistics, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France

    M. Levaillant & J. F. Hamel

  6. UMR INSERM 1235, TENS, Université de Nantes, Rue Alexis Ricordeau, 44000, Nantes, France

    Aurélien Venara

Authors
  1. P. Viannay
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  2. A. Hamy
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  3. R. Jaouen
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  4. F. X. Caroli-Bosc
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  5. C. Luel
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  6. S. Vasseur
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  7. M. Levaillant
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  8. J. F. Hamel
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  9. Aurélien Venara
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Contributions

A Venara and P Viannay made substantial contributions to the conception and design of this work, acquisition and interpretation of data and drafted the manuscript. They gave their final approval of the version to be published and their agreement to be held accountable for all aspects of the work.

A Hamy, R Jaouen, C Luel, FX Caroli-Bosc, and S Vasseur made substantial contributions to the acquisition and interpretation of data and critically revised the manuscript, as well as giving their final approval of the version to be published and their agreement to be held accountable for all aspects of the work.

M Levaillant and JF Hamel made substantial contributions to the interpretation and analysis of data and drafted the manuscript, as well as giving his final approval of the version to be published and his agreement to be held accountable for all aspects of the work.

Corresponding author

Correspondence to Aurélien Venara.

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Conflict of interest

P Viannay, A Hamy, R Jaouen, FX Caroli-Bosc, C Luel, S Vasseur, M Levaillant, JF Hamel, and A Venara have no conflicts of interest or financial ties related to this work to disclose.

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Viannay, P., Hamy, A., Jaouen, R. et al. Does enhanced recovery improve the survival rates of patients 3 years after undergoing surgery to remove a tumor in the colon?. Int J Colorectal Dis 34, 441–449 (2019). https://doi.org/10.1007/s00384-018-3205-5

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  • DOI: https://doi.org/10.1007/s00384-018-3205-5

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