International Journal of Colorectal Disease

, Volume 33, Issue 8, pp 1131–1134 | Cite as

A study of using carbon nanoparticles to improve lymph nodes staging for laparoscopic-assisted radical right hemicolectomy in colon cancer

  • Pan Lelin 
  • Ye Feng 
  • Liu Jing-jing 
  • Ba Xiao-qun 
  • Sheng Qin-song 
Short Communication



This study aimed to analyze and evaluate the feasibility of using carbon nanoparticles (CNs) to track lymph nodes (LNs) metastases in right colon tumors, especially for patients who underwent laparoscopic-assisted radical right hemicolectomy.


A total of 99 patients were enrolled in this retrospective study between November 2015 and September 2017 (control group n = 47). One day before surgery, 1 ml of CNs suspension was injected into the submucosal layer around the site of the primary lesions by colonoscopy. Then complete mesocolic excision (CME) of laparoscopic right hemicolectomy was performed. CNs-stained LNs were identified and counted from all dissected LNs after surgery.


The dates showed that the number of total harvested LNs and the number of positive patients in the experimental group increased significantly compared with the control group (respectively, P < 0.01 and P < 0.05). The increase of positive percentage shifted some patients toward higher stage, although the total number of positive LNs changed a little bit. In addition, the duration for pathologist to dissect LNs became shorter (26.4 vs. 31.1 min, P < 0.05).


Therefore, the CNs are not only a good tattoo in laparoscopic-assisted operation, but could be regarded as a better pathological evaluating tool for tumor treatment.


Carbon nanoparticles Lymph node Laparoscopic right hemicolectomy Colon cancer 


Funding information

This study is supported by Natural Science Foundation of Zhejiang Province of China (No. LY18H160018).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Colorectal Surgery, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  2. 2.Department of Pathology, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina

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