Abstract
Purpose
This study aims to understand the clinical characteristics of preterm neonatal necrotizing enterocolitis (NEC) to improve the medical management level.
Methods
The clinical characteristics of preterm NEC infants with low birth weight (LBW, ≥ 1500 g) and very low birth weight (VLBW, < 1500 g) were compared. Then, clinical information, including demographics, surgical interventions and morbidity, were collected.
Results
A total of 149 preterm NEC infants (60 with VLBW and 89 with LBW) were enrolled. Their median birth weight and gestational age were 1600 g and 31 weeks, respectively. Respiratory support and surfactant therapy were more frequent in VLBW infants (90% vs. 38% and 75% vs. 21.3%) than in LBW infants. In addition, 70.5% of these infants were fed by formula before the NEC occurred. Prematurity-associated morbidities were significantly higher in VLBW infants. Furthermore, 12.8% of all NEC infants died at discharge, and mortality was more prevalent in VLBW infants (21.7% vs. 6.7%). The most frequently received surgeries were enterostomy (n = 58), primary anastomosis (n = 42), and peritoneal drainage (n = 2). Multifocal, localized and pan-intestinal disease occurred in 77.5%, 19.6% and three infants, respectively. Furthermore, postoperative complications occurred more frequently in VLBW infants.
Conclusion
The overall mortality was 12.8% for infants who had a larger mean gestational age and birth weight, when compared to that in developed countries. Higher rate of formula feeding might be an important risk factor for NEC development. Furthermore, mortality and morbidities, especially nutrition-associated complications, were more frequent in VLBW infants.
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References
Holman RC, Stoll BJ, Curns AT, Yorita KL, Steiner CA, Schonberger LB (2006) Necrotising enterocolitis hospitalisations among neonates in the United States. Paediatr Perinat Epidemiol 20:498–506
Fitzgibbons SC, Ching Y, Yu D, Carpenter J, Kenny M, Weldon C, Lillehei C, Valim C, Horbar JD, Jaksic T (2009) Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg 44:1072–1075; (discussion 1075–1076)
Neu J (2014) Necrotizing enterocolitis. World Rev Nutr Diet 110:253–263
Srinivasan PS, Brandler MD, D’Souza A (2008) Necrotizing enterocolitis. Clin Perinatol 35:251–272
Neu J, Walker WA (2011) Necrotizing enterocolitis. N Engl J Med 364:255–264
Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, Brotherton T (1978) Neonatal necrotizing enterocolitis. therapeutic decisions based upon clinical staging. Ann Surg 187:1–7
Duci M, Fascetti-Leon F, Erculiani M, Priante E, Cavicchiolo ME, Verlato G, Gamba P (2018) Neonatal independent predictors of severe NEC. Pediatr Surg Int 34:663–669
Andorsky DJ, Lund DP, Lillehei CW, Jaksic T, Dicanzio J, Richardson DS, Collier SB, Lo C, Duggan C (2001) Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr 139:27–33
An international classification of retinopathy of prematurity. The committee for the classification of retinopathy of prematurity (1984). Arch Ophthalmol 102:1130–1134
Volpe JJ (2001) Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 50:553–562
Jobe AH, Bancalari E (2001) Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163:1723–1729
Sekar KC (2010) Protective strategies to prevent patent ductus arteriosus. Chin Med J (Engl) 123:2914–2918
Sharef SW, Al-Sinani S, Al-Naamani K, Al-Zakwani I, Reyes ZS, Al-Ryiami H, Khan AA, Al-Mamari W (2015) Incidence and risk factors of parenteral nutrition-associated cholestasis in omani neonates: single centre experience. Sultan Qaboos Univ Med J 15:e234–e240
Fasoli L, Turi RA, Spitz L, Kiely EM, Drake D, Pierro A (1999) Necrotizing enterocolitis: extent of disease and surgical treatment. J Pediatr Surg 34:1096–1099
Hull MA, Fisher JG, Gutierrez IM, Jones BA, Kang KH, Kenny M, Zurakowski D, Modi BP, Horbar JD, Jaksic T (2014) Mortality and management of surgical necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study. J Am Coll Surg 218:1148–1155
Rees CM, Eaton S, Pierro A (2010) National prospective surveillance study of necrotizing enterocolitis in neonatal intensive care units. J Pediatr Surg 45:1391–1397
Gane B, Bhat BV, Adhisivam B, Joy R, Prasadkumar P, Femitha P, Shruti B (2014) Risk factors and outcome in neonatal necrotising enterocolitis. Indian J Pediatr 81:425–428
Lu Q, Cheng S, Zhou M, Yu J (2017) Risk factors for necrotizing enterocolitis in neonates: a retrospective case-control study. Pediatr Neonatol 58:165–170
Alshaikh B, Kostecky L, Blachly N, Yee W (2015) Effect of a quality improvement project to use exclusive mother’s own milk on rate of necrotizing enterocolitis in preterm infants. Breastfeed Med 10:355–361
Hourigan SK, Ta A, Wong WS, Clemency NC, Provenzano MG, Baveja R, Iyer R, Klein E, Niederhuber JE (2016) The microbiome in necrotizing enterocolitis: a case report in twins and minireview. Clin Ther 38:747–753
Stewart CJ, Marrs EC, Nelson A, Lanyon C, Perry JD, Embleton ND, Cummings SP, Berrington JE (2013) Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis. PLoS One 8:e73465
Su BH (2014) Optimizing nutrition in preterm infants. Pediatr Neonatol 55:5–13
Youn YA, Kim EK, Kim SY (2015) Necrotizing enterocolitis among very-low-birth-weight infants in Korea. J Korean Med Sci 30(Suppl 1):S75–S80
Murthy K, Yanowitz TD, DiGeronimo R et al (2014) Short-term outcomes for preterm infants with surgical necrotizing enterocolitis. J Perinatol 34:736–740
Chedid F, Shanteer S, Haddad H, Musharraf I, Shihab Z, Imran A, Adma HA, Salman N, Rahmani A (2009) Short-term outcome of very low birth weight infants in a developing country: comparison with the Vermont Oxford Network. J Trop Pediatr 55:15–19
Yan W, Hong L, Wang Y, Feng Y, Lu L, Tao Y, Wu J, Ruan H, Tang Q, Cai W (2017) Retrospective dual-center study of parenteral nutrition-associated cholestasis in premature neonates: 15 years’ experience. Nutr Clin Pract 32:407–413
Rehman MU, Narchi H (2015) Metabolic bone disease in the preterm infant: current state and future directions. World J Methodol 5:115–121
Kim AY, Lim RK, Han YM, Park KH, Byun SY (2016) Parenteral nutrition-associated cholestasis in very low birth weight infants: a single center experience. Pediatr Gastroenterol Hepatol Nutr 19:61–70
Hong CR, Fullerton BS, Mercier CE, Morrow KA, Edwards EM, Ferrelli KR, Soll RF, Modi BP, Horbar JD, Jaksic T (2018) Growth morbidity in extremely low birth weight survivors of necrotizing enterocolitis at discharge and two-year follow-up. J Pediatr Surg 53:1197–1202
Collaborative Group for the Nutritional G, Developmental Study on Very Low Birth Weight I (2013) Postnatal growth of very low birth weight infants during hospitalization. Zhonghua Er Ke Za Zhi 51:4–11
Marques PC, Rocha G, Flor-De-Lima F, Guimaraes H (2018) Extrauterine growth restriction at discharge in very low birth weight infants: a retrospective study in a level III neonatal intensive care unit. Minerva Pediatr. https://doi.org/10.23736/S0026-4946.18.05253-2
Henry MCW, RL M (2010) Necrotizing enterocolitis. In: Ashcraft KW, Holcomb GJ, DJ O (eds) Ashcraft’s pediatric surgery, 5th edn. Elsevier, Philadelphia, pp 439–455
Rees CM, Eaton S, Kiely EM, Wade AM, McHugh K, Pierro A (2008) Peritoneal drainage or laparotomy for neonatal bowel perforation? A randomized controlled trial. Ann Surg 248:44–51
Al-Hudhaif J, Phillips S, Gholum S, Puligandla PP, Flageole H (2009) The timing of enterostomy reversal after necrotizing enterocolitis. J Pediatr Surg 44:924–927
Sheng Q, Lv Z, Xu W, Liu J, Wu Y, Shi J, Xi Z (2016) Short-term surgical outcomes of preterm infants with necrotizing enterocolitis: a single-center experience. Medicine (Baltimore) 95:e4379
Wright NJ, Thyoka M, Kiely EM, Pierro A, De Coppi P, Cross KM, Drake DD, Peters MJ, Curry JI (2014) The outcome of critically ill neonates undergoing laparotomy for necrotising enterocolitis in the neonatal intensive care unit: a 10-year review. J Pediatr Surg 49:1210–1214
Battersby C, Santhalingam T, Costeloe K, Modi N (2018) Incidence of neonatal necrotising enterocolitis in high-income countries: a systematic review. Arch Dis Child Fetal Neonatal Ed 103:F182–F189
Federici S, L DEB, Straziuso S et al (2017) Multicenter retrospective study on management and outcome of newborns affected by surgical necrotizing enterocolitis. Minerva Chir 72:183–187
Acknowledgements
The work performed by the authors is supported by the Zhejiang Medical and Health Science and Technology Project (no. 2017KY432 and no. 2017200317), and the Natural Science Foundation of Zhejiang Province of China (Grant no. LQ17H090004).
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This study was approved by the Ethics Committee of the Children’s Hospital of Zhejiang University, School of Medicine. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki declaration and its later amendments, or comparable ethical standards.
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This retrospective de-identified study does not require individual informed consents.
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Lin, H., Mao, S., Shi, L. et al. Clinical characteristic comparison of low birth weight and very low birth weight preterm infants with neonatal necrotizing enterocolitis: a single tertiary center experience from eastern China. Pediatr Surg Int 34, 1201–1207 (2018). https://doi.org/10.1007/s00383-018-4339-9
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DOI: https://doi.org/10.1007/s00383-018-4339-9