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Pediatric Surgery International

, Volume 34, Issue 7, pp 769–774 | Cite as

Effectiveness of gabapentin as a postoperative analgesic in children undergoing appendectomy

  • Katherine J. Baxter
  • Jennifer Hafling
  • Jennifer Sterner
  • Adarsh U. Patel
  • Helen Giannopoulos
  • Kurt F. Heiss
  • Mehul V. Raval
Original Article

Abstract

Purpose

Though gabapentin is increasingly used as a perioperative analgesic, data regarding effectiveness in children are limited. The purpose of this study was to evaluate gabapentin as a postoperative analgesic in children undergoing appendectomy.

Methods

A 12-month retrospective review of children undergoing appendectomy was performed at a two-hospital children’s institution. Patients receiving gabapentin (GP) were matched (1:2) with patients who did not receive gabapentin (NG) based on age, sex and appendicitis severity. Outcome measures included postoperative opioid use, pain scores, and revisits/readmissions.

Results

We matched 29 (33.3%) GP patients with 58 (66.6%) NG patients (n = 87). The GP group required significantly less postoperative opioids than the NG group (0.034 mg morphine equivalents/kg (ME/kg) vs. 0.106 ME/kg, p < 0.01). Groups had similar lengths of time from operation to pain scores ≤ 3 (GP 12.21 vs. NG 17.01 h, p = 0.23). GP and NG had similar rates of revisit to the emergency department (13.8 vs. 10.3%, p = 0.73), readmission (6.9 vs. 1.7%, p = 0.26), and revisits secondary to surgical pain (3.4 vs. 3.4%, p = 1.00).

Conclusion

In this single-center, retrospective cohort study, gabapentin is associated with a reduction in total postoperative opioid use in children with appendicitis. While promising, further prospective validation of clinical effectiveness is needed.

Keywords

Gabapentin Appendectomy Abdominal surgery Opioid epidemic Analgesic 

Abbreviations

ERP

Enhanced recovery protocol

VAS

Visual analog scale

LOS

Length of stay

ME

Morphine equivalents in mg

Notes

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare. Institutional Review Board approval was obtained prior to chart review and all protected health information was kept strictly confidential. Informed consent was waived given the retrospective nature of the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Katherine J. Baxter
    • 1
  • Jennifer Hafling
    • 2
  • Jennifer Sterner
    • 2
  • Adarsh U. Patel
    • 1
  • Helen Giannopoulos
    • 2
  • Kurt F. Heiss
    • 1
  • Mehul V. Raval
    • 1
  1. 1.Division of Pediatric Surgery, Department of SurgeryEmory University School of Medicine, Children’s Healthcare of AtlantaAtlantaUSA
  2. 2.Department of PharmacyChildren’s Healthcare of AtlantaAtlantaUSA

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