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Pediatric Surgery International

, Volume 34, Issue 1, pp 29–34 | Cite as

Image-based surgical risk factors for Wilms tumor

  • Takaharu Oue
  • Akihiro Yoneda
  • Noriaki Usui
  • Takashi Sasaki
  • Masahiro Zenitani
  • Natsumi Tanaka
  • Shuichiro Uehara
  • Soji Ibuka
  • Yuichi Takama
  • Hiroomi Okuyama
Original Article
  • 258 Downloads

Abstract

Purpose

The standard treatment for Wilms tumor (WT) is primary resection. However, in cases with unresectable tumor or tumor spillage, which are considered to have high surgical risks, more intensive chemotherapy and radiotherapy are required. In the present study, we retrospectively analyzed preoperative image parameters to identify factors associated with surgical risks.

Methods

Twenty-nine patients with WT were enrolled in this study. Data on various preoperative image parameters, such as tumor size, tumor volume, displacement of great vessels, and contralateral extension of the tumor were collected, and their relationship with surgical factors, including operative time, hemorrhage, tumor spillage, and unresectability were analyzed.

Results

Patients with unresectable tumor or with tumor spillage (surgical high-risk group) more frequently demonstrated displacement of great vessels and contralateral tumor extension. Operative time and blood loss were also significantly related to tumor size, area, volume, displacement of great vessels and contralateral extension.

Conclusion

Besides tumor size, displacement of great vessels and contralateral extension were significantly associated with surgical risks. These factors are easily determined using CT images and are, therefore, useful to decide whether preoperative chemotherapy should be started instead of primary tumor resection for large localized WTs.

Keywords

Wilms tumor Surgical risk Tumor size Contralateral extension Displacement of great vessels 

Notes

Acknowledgements

This work was not supported by any external funding sources.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest in association with this study.

Ethical approval

This study was approved by the Ethics Committee of our hospital (IRB approval number 2006). Additionally, since this was a retrospective study, formal patient consent was not required.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Takaharu Oue
    • 1
  • Akihiro Yoneda
    • 2
  • Noriaki Usui
    • 3
  • Takashi Sasaki
    • 1
  • Masahiro Zenitani
    • 1
  • Natsumi Tanaka
    • 1
  • Shuichiro Uehara
    • 2
  • Soji Ibuka
    • 3
  • Yuichi Takama
    • 4
  • Hiroomi Okuyama
    • 4
  1. 1.Department of Pediatric SurgeryHyogo College of MedicineNishinomiyaJapan
  2. 2.Department of Pediatric SurgeryOsaka City General HospitalOsaka-shiJapan
  3. 3.Department of Pediatric SurgeryOsaka Women’s and Children’s HospitalIzumiJapan
  4. 4.Department of Pediatric SurgeryOsaka University Graduate School of MedicineSuitaJapan

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