Fronto-orbital advancement in a patient with Marshall-Smith syndrome: a case report and review of the literature



The present report aimed to document the clinical features of a case of Marshall-Smith syndrome (MSS), an extremely rare embryonic developmental disorder with associated craniosynostosis.

Patient and method

We presented herein a case of a 2-year-old female patient with MSS who underwent fronto-orbital advancement for multisuture craniosynostosis.


The patient’s proptosis improved after surgery, and no further surgical intervention was required for corneal exposure. A second FOA followed by revision tarsorrhaphy further improved eye closure.


Surgical procedures to correct dysplastic features and limit neurological impairment are a worthwhile supportive treatment for improving the quality of life and general condition of patients with MSS.

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Correspondence to Bettina Knie.

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Knie, B., Morota, N., Ihara, S. et al. Fronto-orbital advancement in a patient with Marshall-Smith syndrome: a case report and review of the literature. Childs Nerv Syst 37, 677–682 (2021).

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  • Fronto-orbital advancement
  • Marshall-Smith syndrome
  • Craniofacial dysmorphism
  • Exophthalmos