Epilepsy surgery in tuberous sclerosis complex (TSC): emerging techniques and redefinition of treatment goals


Epilepsy occurs in nearly all patients with tuberous sclerosis and is often refractory to medical treatment. The definition of surgical candidacy in these patients has broadened in recent years due to philosophical and technological advances. The goals of surgery have shifted to focusing on quality of life and maximizing neurodevelopmental potential in patients unable to obtain seizure freedom. Novel diagnostic, ablative, and neuromodulatory techniques have been developed that may help patients that were previously considered inoperable to have an improved quality of life. In the coming years, it is expected that these techniques will be further refined and lead to an improvement of neurological prognosis in patients with tuberous sclerosis.

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J. T, H. L, and J.R. prepared the original draft of the manuscript. All authors reviewed and edited the final draft.

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Correspondence to Howard L. Weiner.

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Treiber, J.M., Curry, D.J., Weiner, H.L. et al. Epilepsy surgery in tuberous sclerosis complex (TSC): emerging techniques and redefinition of treatment goals. Childs Nerv Syst (2020). https://doi.org/10.1007/s00381-020-04715-2

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  • Tuberous sclerosis
  • Epilepsy
  • Surgery
  • Laser ablation
  • Stereo EEG