Skip to main content

Advertisement

SpringerLink
Log in

Monitoring optic chiasmatic-hypothalamic glioma volumetric changes by MRI in children under clinical surveillance or chemotherapy

  • Original Paper
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Purpose

Optic pathway gliomas represent 5% of pediatric brain tumors and are typically low-grade lesions. Because of their unpredictable clinical course, adequate treatment approaches have been controversial, involving surveillance, surgery, chemotherapy, and radiotherapy. In this study, we use volumetric imaging to compare evolution of optic chiasmatic-hypothalamic gliomas (OCHG) treated with and without chemotherapy, analyzing tumor volume variation during the overall period.

Methods

A total of 45 brain MRI were retrospectively analyzed for 14 patients with OCHG. Volumetric assessment of the lesions was performed by a neuroradiologist, using software DISPLAY. OCHG patients were allocated into two groups: group 1 (n = 8) who underwent chemotherapy and group 2 (n = 6) who did not receive chemotherapy. Outcome analysis was performed comparing tumor volume evolution of these two groups.

Results

The results showed a reduction of 4.4% of the volume of the lesions for group 1 after the end of chemotherapy, with an increase of 5.3% in volume in the late follow-up examination. For group 2, we found a slight reduction (5%) of the overall volume of the lesions, both with no statistical significance (p > 0.05).

Conclusions

From the limited series analyzed in this study, no significant differences were observed in relation to the volume change of lesions treated or not treated with chemotherapy. Larger prospective clinical trials are needed to better evaluate the effect of chemotherapy and radiological response of OCHG.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Shamji MF, Benoit BG (2007) Syndromic and sporadic pediatric optic pathway gliomas: review of clinical and histopathological differences and treatment implications. Neurosurg Focus 23:E3

    Article  PubMed  Google Scholar 

  2. Binning MJ, Liu JK, Kestle JR, Brockmeyer DL, Walker ML (2007) Optic pathway gliomas: a review. Neurosurg Focus 23:E2

    Article  PubMed  Google Scholar 

  3. Kornreich L et al (2001) Optic pathway glioma: correlation of imaging findings with the presence of neurofibromatosis. Am J Neuroradiol 22(10):1963–1969

    CAS  PubMed  Google Scholar 

  4. Dutton JJ (1994) Gliomas of the anterior visual pathway. Surv Ophthalmol 38(5):427–452

    Article  CAS  PubMed  Google Scholar 

  5. Avery RA, Fisher MJ, Liu GT (2011) Optic pathway gliomas. J Neuroophthalmol 31(3):269–278

    Article  PubMed  Google Scholar 

  6. Danoff BF, Kramer S, Thompson N (1980) The radiotherapeutic management of optic nerve gliomas in children. Int J Radiat Oncol Biol Phys 6(1):45–50

    Article  CAS  PubMed  Google Scholar 

  7. Tao ML, Barnes PD, Billett AL, Leong T, Shrieve DC, Scott RM, Tarbell NJ (1997) Childhood optic chiasm gliomas: radiographic response following radiotherapy and long-term clinical outcome. Int J Radiat Oncol Biol Phys 39:579–587

    Article  CAS  PubMed  Google Scholar 

  8. Wisoff JH (1992) Management of optic pathway tumors of childhood. Neurosurg Clin N Am 3:791–802

    Article  CAS  PubMed  Google Scholar 

  9. Alvord EC Jr, Lofton S (1988) Gliomas of the optic nerve or chiasm. Outcome by patients’ age, tumor site and treatment. J Neurosurg 68:85–98

    Article  PubMed  Google Scholar 

  10. Horwich A, Bloom HJG (1985) Optic gliomas: radiation therapy and prognosis. Int J Radiat Oncol Biol Phys 11:1067–1079

    Article  CAS  PubMed  Google Scholar 

  11. Jenkin D, Angyalfi S, Becker L et al (1993) Optic glioma in children: Surveillance, resection, or irradiation? Int J Radiat Oncol Biol Phys 25:215–225

    Article  CAS  PubMed  Google Scholar 

  12. Packer RJ et al (1997) Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 86(5):747–754

    Article  CAS  PubMed  Google Scholar 

  13. Erkal HŞ, Serin M, Çakmak A (1997) Management of optic pathway and chiasmatic-hypothalamic gliomas in children with radiation therapy. Radiother Oncol 45(1):11–15

    Article  CAS  PubMed  Google Scholar 

  14. Packer RJ, Sutton LN, Bilaniuk LT, Radcliffe J, Rosenstock JG, Siegel KR, Bunin GR, Savino PJ, Bruce DA, Schut L (1988) Treatment of chiasmatic/hypothalamic gliomas of childhood with chemotherapy: an update. Ann Neurol 23:79–85

    Article  CAS  PubMed  Google Scholar 

  15. Grabenbauer GG et al (2000) Radiation therapy of optico–hypothalamic gliomas (OHG)–radiographic response, vision and late toxicity. Radiother Oncol 54(3):239–245

    Article  CAS  PubMed  Google Scholar 

  16. Grill J, Couanet D, Cappelli C, Habrand JL, Rodriguez D, Sainte-Rose C, Kalifa C (1999) Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma. Ann Neurol 45(3):393–396

    Article  CAS  PubMed  Google Scholar 

  17. Jahraus CD, Tarbell NJ (2006) Optic pathway gliomas. Pediatr Blood Cancer 46(5):586–596

    Article  PubMed  Google Scholar 

  18. Lafay-Cousin L, Holm S, Qaddoumi I, Nicolin G, Bartels U, Tabori U, Huang A, Bouffet E (2005) Weekly vinblastine in pediatric low-grade glioma patients with carboplatin allergic reaction. Cancer 103:2636–2642

    Article  CAS  PubMed  Google Scholar 

  19. Lancaster DL, Hoddes JA, Michalski A (2003) Tolerance of nitrosurea-based multiagent chemotherapy regime for low-grade pediatric gliomas. J Neuro-Oncol 63:289–294

    Article  CAS  Google Scholar 

  20. Listernick R, Ferner RE, Liu GT, Gutmann DH (2007) Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations. Ann Neurol 61:189–198

    Article  CAS  PubMed  Google Scholar 

  21. Grill J, Laithier V, Rodriguez D, Raquin MA, Pierre-Kahn A, Kalifa C (2000) When do children with optic pathway tumours need treatment? An oncological perspective in 106 patients treated in a single centre. Eur J Pediatr 159:692–696

    Article  CAS  PubMed  Google Scholar 

  22. Shofty B et al (2011) Visual outcome following chemotherapy for progressive optic pathway gliomas. Pediatr Blood Cancer 57(3):481–485

    Article  PubMed  Google Scholar 

  23. Fisher MJ, et al. (2012) Visual outcomes in children with neurofibromatosis type 1–associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis. Neuro-oncology nos076

  24. Shofty B et al (2011) MRI internal segmentation of optic pathway gliomas: clinical implementation of a novel algorithm. Childs Nerv Syst 27(8):1265–1272

    Article  PubMed  Google Scholar 

  25. Taylor T, et al (2014) Radiological classification of optic pathway gliomas: experience of a modified functional classification system. Br J Radiol

  26. Gnekow AK (1995) Recommendations of the brain tumor subcommittee for the reporting of trials. Med Pediatr Oncol 24(2):104–108

    Article  CAS  PubMed  Google Scholar 

  27. Opocher E et al (2006) Prognostic factors for progression of childhood optic pathway glioma: a systematic review. Eur J Cancer 42(12):1807–1816

    Article  PubMed  Google Scholar 

  28. Czyzyk E et al (2003) Optic pathway gliomas in children with and without neurofibromatosis 1. J Child Neurol 18(7):471–478

    Article  PubMed  Google Scholar 

  29. Chateil JF, Soussotte C, Pedespan JM, Brun M, Le Manh C, Diard F (2001) MRI and clinical differences between optic pathway tumours in children with and without neurofibromatosis. Br J Radiol 74:24–31

    Article  CAS  PubMed  Google Scholar 

  30. Shofty B et al (2015) The effect of chemotherapy on optic pathway gliomas and their sub-components: A volumetric MR analysis study. Pediatr Blood Cancer 62(8):1353–1359

    Article  CAS  PubMed  Google Scholar 

  31. Moreno L et al (2010) Does chemotherapy affect the visual outcome in children with optic pathway glioma? A systematic review of the evidence. Eur J Cancer 46(12):2253–2259

    Article  PubMed  Google Scholar 

  32. Gaonkar B, Macyszyn L, Bilello M, Sadaghiani MS, Akbari H, Attiah MA, Ali ZS, da X, Zhan Y, Rourke DO’, Grady SM, Davatzikos C (2015) Automated tumor volumetry using computer-aided image segmentation. Acad Radiol 22(5):653–661

    Article  PubMed  PubMed Central  Google Scholar 

  33. Clarke LP, Velthuizen RP, Clark M, Gaviria J, Hall L, Goldgof D, Murtagh R, Phuphanich S, Brem S (1998) MRI measurement of brain tumor response: comparison of visual metric and automatic segmentation. Magn Reson Imaging 16(3):271–279

    Article  CAS  PubMed  Google Scholar 

  34. Dempsey MF, Condon BR, Hadley DM (2005) Measurement of tumor “size” in recurrent malignant Glioma: 1D, 2D, or 3D? AJNR Am J Neuroradiol 26:770–776

    PubMed  Google Scholar 

  35. Kanaly CW, Mehta AI, Ding D, Hoang JK, Kranz PG, Herndon JE II, Coan A, Crocker I, Waller AF, Friedman AH, Reardon DA, Sampson JH (2014) A novel, reproducible, and objective method for volumetric magnetic resonance imaging assessment of enhancing glioblastoma. J Neurosurg 121(3):536–542

    Article  PubMed  PubMed Central  Google Scholar 

  36. Warren KE, Patronas N, Aikin AA, Albert PS, Balis FM (2001) Comparison of one-, two-, and three-dimensional measurements of childhood brain tumors. J Natl Cancer Inst 93(18):1401–1405

    Article  CAS  PubMed  Google Scholar 

  37. Joe BN, Fukui MB, Meltzer CC, Huang Q-s, Day RS, Greer PJ, Bozik ME (1999) Brain tumor volume measurement: comparison of manual and semiautomated methods. Radiology 212(3):811–816

    Article  CAS  PubMed  Google Scholar 

  38. Chow DS, Qi J, Guo X, Miloushev VZ, Iwamoto FM, Bruce JN, Lassman AB, Schwartz LH, Lignelli A, Zhao B, Filippi CG (2014) Semiautomated volumetric measurement on postcontrast MR imaging for analysis of recurrent and residual disease in glioblastoma multiforme. Am J Neuroradiol 35(3):498–503

    Article  CAS  PubMed  Google Scholar 

  39. Galanis E et al (2006) Validation of neuroradiologic response assessment in gliomas: measurement by RECIST, two-dimensional, computer-assisted tumor area, and computer-assisted tumor volume methods. Neuro-oncology 8(2):156–165

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Radiology, Department of Clinics, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil

    Nathalia Cunha Calixto, Gustavo Novelino Simão, Antonio Carlos dos Santos, Murilo Bicudo Cintra & Alessandro Spano Mello

  2. Division of Pediatric Neurosurgery, Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil

    Ricardo Santos de Oliveira

  3. Division of Pediatric Neuroncology, Department of Pediatrics, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil

    Luiz Guilherme Darrigo Junior & Elvis Terci Valera

Authors
  1. Nathalia Cunha Calixto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gustavo Novelino Simão
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonio Carlos dos Santos
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ricardo Santos de Oliveira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Luiz Guilherme Darrigo Junior
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Elvis Terci Valera
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Murilo Bicudo Cintra
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alessandro Spano Mello
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nathalia Cunha Calixto.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Calixto, N.C., Simão, G.N., dos Santos, A.C. et al. Monitoring optic chiasmatic-hypothalamic glioma volumetric changes by MRI in children under clinical surveillance or chemotherapy. Childs Nerv Syst 35, 63–72 (2019). https://doi.org/10.1007/s00381-018-3904-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-018-3904-9

Keywords

Search

Navigation