Peripheral nervous system maturation in preterm infants: longitudinal motor and sensory nerve conduction studies
To study the evolution of sensory-motor nerves in the upper and lower limbs in neurologically healthy preterm infants and to use sensory-motor studies to compare the rate of maturation in preterm infants at term age and full-term healthy neonates.
The study comprised 26 neurologically normal preterm infants born at 23–33 weeks of gestational age, who underwent sensory nerve conduction and motor nerve conduction studies from plantar medial and median nerves and from tibial and ulnar nerves, respectively. We repeated the same neurophysiological studies in 19 of the preterm infants every 2 weeks until postnatal term age. The data from the preterm infants at term was matched with a group of ten full-term babies a few days after birth.
The motor nerve conduction velocity of the tibial and ulnar nerves showed progressive increases in values in relation to gestational age, but there was a decrease of values in distal latencies and F wave latencies. Similarly, there was a gradual increase of sensory nerve conduction velocity values of the medial plantar and median nerves and decreases in latencies in relation to gestational age. At term age, the preterm infants showed significantly lower values of conduction velocities and distal latencies than the full-term neonates. These results were probably because the preterm infants had significantly lower weights, total length and, in particular, distal segments of the limbs at term age.
The sensory-motor conduction parameters were clearly related to gestational age, but extrauterine life did not affect the maturation of the peripheral nervous system in the very preterm babies who were neurologically healthy.
KeywordsMyelination Nerve conduction Preterm infants Peripheral nervous system
Compound muscle action potential
Central nervous system
Motor nerve conduction velocity
Peripheral nervous system
Sensory action potential
Sensory nerve conduction velocity
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Bertini G (2009) The extremely preterm births in Florence. Arch Dis Child Fetal Neonatal Ed 94:231–232Google Scholar
- 2.Zeitlin J, Manktelow BN, Piedvache A, Cuttini M, Boyle E, van Heijst A et al (2016) Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort. BMJ i2976:354Google Scholar
- 3.Draper ES, Zeitlin J, Fenton AC, Weber T, Gerrits J, Martens G, Misselwitz B (2009) Breart G; MOSAIC research group. Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort. Arch Dis Child Fetal Neonatal Ed 94(3):F158–F163CrossRefPubMedGoogle Scholar
- 17.Volpe JJ (2001) Neurology of the newborns. Neuronal proliferation, migration, organization, and myelination 45–88Google Scholar
- 23.Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Löfqvist C, van Marter L, van Weissenbruch M, Ramenghi LA, Beardsall K, Dunger D, Hård AL, Smith LE (2016) Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr 105(6):576–586CrossRefPubMedPubMedCentralGoogle Scholar