Abstract
Introduction
Here we are presenting a unique case of malignant triton tumor of the trigeminal nerve in a 4-year-old boy who presented with diplopia and ptosis.
Intervention
Near total excision of the tumor was performed, and adjuvant chemotherapy and radiotherapy were administered.
Results
The patient is in good health and has no evidence of clinical and radiological tumor recurrence for 22 months.
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References
Bergamaschi L, Bisogno G, Manzitti C, D’Angelo P, Milano GM, Scagnellato A, Cappelletti M, Chiaravalli S, Dall’Igna P, Alaggio R, Ruggiero A, Di Martino M, Affinita MC, Pierobon M, Garaventa A, Casanova M, Ferrari A (2017) Salvage rates and prognostic factors after relapse in children and adolescents with malignant peripheral nerve sheath tumors. Pediatr Blood Cancer. https://doi.org/10.1002/pbc.26816
Brooks JS, Freeman M, Enterline HT (1985) Malignant “Triton” tumors. Natural history and immunohistochemistry of nine new cases with literature review. Cancer 55(11):2543–2549. https://doi.org/10.1002/1097-0142(19850601)55:11<2543::AID-CNCR2820551105>3.0.CO;2-4
Ducatman BS, Scheithauer BW (1984) Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer 54(6):1049–1057. https://doi.org/10.1002/1097-0142(19840915)54:6<1049::AID-CNCR2820540620>3.0.CO;2-1
Filler AG, Belzberg AJ, Chen L, Malessy JA (2017) Peripheral nerves. In: Winn HR (ed) Youmans and Winn neurological surgery. Elsevier, Philadelphia, pp 2113–2116
Gong L, Liu XY, Zhang WD, Han XJ, Yao L, Zhu SJ, Lan M, Li YH, Zhang W (2012) A rare case of malignant triton tumor in the cerebellopontine angle. Diagn Pathol 7(1):43. https://doi.org/10.1186/1746-1596-7-43
Hiranandani LH, Hiranandani NL, Hiranandani GK (1967) Malignant schwannoma (neurogenic sarcoma). J Laryngol Otol 81(12):1409–1413. https://doi.org/10.1017/S0022215100068407
Kar M, Deo SV, Shukla NK, Malik A, DattaGupta S, Mohanti BK, Thulkar S (2006) Malignant peripheral nerve sheath tumors (MPNST)—clinicopathological study and treatment outcome of twenty-four cases. World J Surg Oncol 4(1):55. https://doi.org/10.1186/1477-7819-4-55
Koutsimpelas D, Felmeden U, Mann WJ, Brieger J (2011) Analysis of cytogenetic aberrations in sporadic vestibular schwannoma by comparative genomic hybridization. J Neuro-Oncol 103(3):437–443. https://doi.org/10.1007/s11060-010-0412-5
Madrid-Sanchez AJ, Castillo-Rangel C, Contreras-Ayala ML, Ruiz-Garcia E, Castillo-Castro AK, Ramirez-Aguilar R (2016) Maxillary trigeminal schwannoma. Presentation of a case and review of literature. Cir Cir. https://doi.org/10.1016/j.circir.2016.11.008
Masson P (1932) Experimental and spontaneous schwannomas (peripheral gliomas): II. Spontaneous schwannomas. Am J Pathol 8(389–416):311
Matsuo K, Nagano Y, Sugimori K, Taniguchi K, Gorai K, Kunisaki C, Ike H, Tanaka K, Imada T, Kamijo S, Nozawa A, Nakatani Y, Miura Y, Tanaka K, Endo I, Sekido H, Togo S, Shimada H (2005) Primary malignant peripheral nerve-sheath tumor of the common bile duct. J Gastroenterol 40(3):306–311. https://doi.org/10.1007/s00535-004-1540-5
McConnell YJ, Giacomantonio CA (2012) Malignant triton tumors—complete surgical resection and adjuvant radiotherapy associated with improved survival. J Surg Oncol 106(1):51–56. https://doi.org/10.1002/jso.23042
Skorek A, Narozny W, Kuczkowski J, Mikaszewski B (2004) Treatment of malignant peripheral nerve sheath tumors. Ann Otol Rhinol Laryngol 113(3):252. https://doi.org/10.1177/000348940411300316
Smith RE, Kebriaei MA, Gard AP, Mccomb RD, Bridge JA, Lennarson PJ (2014) Intracranial malignant triton tumor in a patient with neurofibromatosis type 1: case report and review of the literature. Brain Tumor Pathology 31(2):149–154. https://doi.org/10.1007/s10014-013-0147-z
Stasik CJ, Tawfik O (2006) Malignant peripheral nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor). Arch Pathol Lab Med 130(12):1878–1881. https://doi.org/10.1043/1543-2165(2006)130[1878:MPNSTW]2.0.CO;2
Stucky CC, Johnson KN, Gray RJ, Pockaj BA, Ocal IT, Rose PS, Wasif N (2012) Malignant peripheral nerve sheath tumors (MPNST): the Mayo Clinic experience. Ann Surg Oncol 19(3):878–885. https://doi.org/10.1245/s10434-011-1978-7
Woodruff JM, Chernik NL, Smith MC, Millett WB, Foote FW Jr (1973) Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant “Triton” tumors). Cancer 32(2):426–439. https://doi.org/10.1002/1097-0142(197308)32:2<426::AID-CNCR2820320221>3.0.CO;2-W
Acknowledgements
We would like to thank Professor Özlem Yapıcıer for her cooperation in pathological diagnosis of the specimens and preparation of pathological pictures for this paper.
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Mallah, F.A., Tanrıkulu, B., Çorapçıoğlu, F. et al. Malignant triton tumor of trigeminal nerve—case report. Childs Nerv Syst 34, 983–986 (2018). https://doi.org/10.1007/s00381-017-3708-3
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DOI: https://doi.org/10.1007/s00381-017-3708-3