Abstract
Objective
Craniosynostosis is the premature fusion of the calvarial sutures and is associated with aesthetic impairment and secondary damage to brain growth. Associated neurological injuries can result from increased intracranial pressure (ICP) and abnormal cerebral blood flow (CBF). Arterial spin-labeling (ASL) MRI was used to assess regional CBF in developing rabbits with early-onset coronal suture synostosis (EOCS) and age-matched wild-type controls (WT).
Methods
Rabbits were subjected to ASL MRI at or near 10, 25, or 42 days of age. Differences in regional CBF were assessed using one-way ANOVA.
Conclusion
CBF was similar in WT and EOCS rabbits with the exception of the peridural surfaces in EOCS rabbits at 25 days of age. A twofold increase in peridural CBF at 25 days of age coincides with a transient increase in ICP. By 42 days of age, CBF in peridural surfaces had decreased.
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Funding
This project was funded by The Walter L. Copeland Fund of the Pittsburgh Foundation. The Pittsburgh NMR Center for Biomedical Research is supported by a grant from the National Institutes of Health (P41EB-001977).
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This study was approved by the University of Pittsburgh Institutional Animal Care and Use Committee. This study was presented in part at the 14th Scientific Meeting of the International Society for Magnetic Resonance in Medicine in Seattle Washington on May 6–12, 2006.
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Foley, L.M., Fellows-Mayle, W., Hitchens, T.K. et al. Age-related peridural hyperemia in craniosynostotic rabbits. Childs Nerv Syst 25, 861–866 (2009). https://doi.org/10.1007/s00381-009-0812-z
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DOI: https://doi.org/10.1007/s00381-009-0812-z