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Cervical lipoblastomatosis producing quadriparesis: case report of surgery with chemotherapy and 10-year follow-up

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Abstract

Introduction

Cervical lipoblastomatosis is a rare spinal tumour. Management of recurrence and long-term outcome data are not well described.

Case report

A 10-month-old infant presented with an upper extremity weakness. Magnetic resonance imaging (MRI) revealed an extradural cervical spinal tumour. It was debulked and histopathology revealed it to be lipoblastomatosis. The infant improved postoperatively. However, 5 months later the patient deteriorated and developed quadriparesis. The patient was managed with a more extensive resection and had chemotherapy. Ten years post-presentation the patient is well having made a full recovery and is living a normal life. Recent MRI shows minimal residual quiescent tumour.

Conclusion

The treatment of cervical lipoblastomatosis should involve the resection of as much tumour as possible at the first sitting as recurrence can be a problem. In cases of spinal recurrence we recommend aggressive decompression and adjuvant chemotherapy.

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References

  1. Al-Salem AH, Al-Nazer M (2003) Mesenteric lipoblastoma in a 2-year-old child. Pediatr Surg Int 19:115–117

    PubMed  Google Scholar 

  2. Batanian JR, Brink DS, Thorpe CM, Haddad BR (2001) Case of lipoblastoma with two derivative chromosomes containing heterogeneously staining-like regions and a review of the literature: lipoblastoma and chromosome 8. Cancer Genet Cytogenet 125:10–13

    Article  CAS  PubMed  Google Scholar 

  3. Chen Z, Coffin CM, Scott S, Meloni-Ehrig A, Shepard R, Issa B, Forsyth DR, Sandberg AA, Brothman AR, Lowichik A (2000) Evidence by spectral karyotyping that 8q11.2 is nonrandomly involved in lipoblastoma. J Mol Diagn 2:73–77

    CAS  PubMed  Google Scholar 

  4. Collins MH, Chatten J (1997) Lipoblastoma/lipoblastomatosis: a clinical pathologic study of 25 tumours. Am J Surg Pathol 21:1131

    CAS  PubMed  Google Scholar 

  5. DePasquale K, Deschler DG (2002) First report of a lipoblastoma of the parapharyngeal space. Ear Nose Throat J 81:564–568

    PubMed  Google Scholar 

  6. Dilley AV, Patel DL, Hicks MJ, Brandt ML (2001) Lipoblastoma: pathophysiology and surgical management. J Pediatr Surg 36:229–231

    CAS  PubMed  Google Scholar 

  7. Duhaine AC, Chatten J, Schut L, Rorke L (1987) Cervical lipoblastomatosis with intraspinal extension and transformation into mature fat in a child. Childs Nerv Syst 3:304–306

    PubMed  Google Scholar 

  8. Francois A, Bodenant C, Rives N, Bachy B, Mitrofanoff P, Mace B, Hemet J (1997) Mesenteric lipoblastoma with changes in chromosome 8: use of cytogenetics in the diagnosis of adipocytic tumors in children. Ann Pathol 17:406–411

    CAS  PubMed  Google Scholar 

  9. Harrer J, Hammon G, Wagner T, Bolkenius M (2001) Lipoblastoma and lipoblastomatosis: a report of two cases and review of the literature. Eur J Pediatr Surg 11:342–349

    Article  Google Scholar 

  10. Hibbard MK, Kozakewich HP, Dal Cin P, Sciot R, Tan X, Xiao S, Fletcher JA (2000) PLAG 1 fusion oncogenes in lipoblastoma. Cancer Res 60:4869–4872

    CAS  PubMed  Google Scholar 

  11. Kamel HAM, Brennan PR, Farrell MA (1999) Cervical epidural lipoblastomatosis: changing MR appearance after chemotherapy. Am J Neuroradiol 20:386–389

    CAS  PubMed  Google Scholar 

  12. Kaufman SL, Stout AP (1958) Lipoblastic tumours of children. Cancer 12:912–925

    Google Scholar 

  13. Ko SF, Shieh CS, Shih TY, Hsiao C, Ng SH, Lee TY, Wan YL, Chew WJ (1998) Mediastinal lipoblastoma with intraspinal extension: MRI demonstration. Magn Reson Imaging 16:445–448

    Article  CAS  PubMed  Google Scholar 

  14. Kuhnen C, Mentzel T, Fisseler-Eckhoff A, Dediec-Rychter M, Sciot R (2002) Atypical lipomatous tumour in a 14-year old patient: distinction from lipoblastoma using FISH analysis. Virchows Arch 441:229–302

    Article  Google Scholar 

  15. Mentzel T, Calionje E, Fletcher CDM (1993) Lipoblastoma and lipoblastomatosis: a clinical pathological study of 14 cases. Histopathology 23:527–533

    CAS  PubMed  Google Scholar 

  16. Miller GG, Yanchar NL, Magee JF, Blair GK (1997) Tumour karyotype differentiates lipoblastoma from liposarcoma. J Pediatr Surg 32:1771–1772

    CAS  PubMed  Google Scholar 

  17. Perlis CS, Collins MH, Honig PJ, Low DW (2000) Forehead lipoblastoma mimicking a hemangioma. Pediatrics 105:123–128

    CAS  PubMed  Google Scholar 

  18. Sawyer JR, Parsons EA, Crowson ML, Smith S, Erickson S, Bell JM (1994) Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma. Cancer Genet Cytogenet 76:39–42

    Article  CAS  PubMed  Google Scholar 

  19. Sciot R, De Wever I, Debiec-Rychter M (2003) Lipoblastoma in a 23 year old male: distinction from atypical lipomatous tumour using cytogenetic and fluorescence in-situ hybridization analysis. Virchows Arch 442:468–471

    PubMed  Google Scholar 

  20. Stewart RJ, Martelli H, Oberlin O, Rey A, Bouvet N, Spicer RD, Godzinski J, Stevens MC, International Society of Pediatric Oncology (2003) Treatment of children with nonmetastatic paratesticular rhabdomyosarcoma: results of the malignant mesenchymal tumors studies (MMT 84 and MMT 89) of the International Society of Pediatric Oncology. J Clin Oncol 21:793–798

    Article  PubMed  Google Scholar 

  21. Stringel G, Shandling B, Mancer K, Ein SH (1982) Lipoblastoma in infants and children. J Pediatr Surg 17:277–280

    PubMed  Google Scholar 

  22. Sun JJ, Rasgon BM, Hilsinger RL (2003) Lipoblastomatosis of the neck causing hemiparesis: a case report and review of the literature. Head Neck 25:337–340

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Royal Liverpool Children’s Hospital NHS Trust, Alder Hey, Eaton Road, Liverpool, L12 2AP, UK

    Donncha O’Brien

  2. Department of Neurosurgery, Beaumont Hospital, Dublin 9, Ireland

    Kristian Aquilina & Daivd Allcutt

  3. Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland

    Michael Farrell

  4. Department of Paediatric Neuro-oncology, Our Lady’s Hospital for Sick Children, Crumlin, Dublin, Ireland

    Fin Breathnach

Authors
  1. Donncha O’Brien
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  2. Kristian Aquilina
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  3. Michael Farrell
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  4. Fin Breathnach
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  5. Daivd Allcutt
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Correspondence to Donncha O’Brien.

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O’Brien, D., Aquilina, K., Farrell, M. et al. Cervical lipoblastomatosis producing quadriparesis: case report of surgery with chemotherapy and 10-year follow-up. Childs Nerv Syst 21, 165–170 (2005). https://doi.org/10.1007/s00381-004-0949-8

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  • DOI: https://doi.org/10.1007/s00381-004-0949-8

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