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Der Ophthalmologe

, Volume 115, Issue 2, pp 93–99 | Cite as

Blepharitiskomponente des trockenen Auges

Leitthema

Zusammenfassung

In dieser Übersicht werden weiterhin relevante ältere sowie neuere Informationen zur chronischen Blepharitis mit Epidemiologie, Symptomen, Befunden und Pathophysiologie insbesondere im Kontext des trockenen Auges dargestellt. Die chronische Blepharitis ist häufig die eigentliche Ursache des trockenen Auges, die nicht selten übersehen wird und unbehandelt bleibt. Sie kann jedoch auch Folge des (hypovolämischen) trockenen Auges sein und teils schweren Komplikationen der Hornhaut zugrunde liegen, die mit Material aus eigenem Patientenarchiv illustriert werden. Neue Erkenntnisse bezüglich der Zusammensetzung der Lipide im Tränenfilm in Korrelation mit denen des Meibom-Drüsen-Sekrets, Hypothese eines Biofilms als Grundlage der chronischen Blepharitis als theoretische, noch nicht bewiesene Ergänzung der bislang bekannten pathophysiologischen Faktoren werden erörtert.

Schlüsselwörter

Meibom-Drüsen-Störung Keratitis Biofilm Lipide Tränenfilm 

Blepharitis component of dry eye syndrome

Abstract

This review contains a compilation of long-standing and more recent relevant information on chronic blepharitis, especially in the context of dry eye disease regarding epidemiology, symptoms, clinical findings and pathophysiology. Chronic blepharitis often represents the underlying cause of dry eye disease but remains undetected and untreated in many cases; however, it can be a result of (hypovolemic) dry eye disease and leads to sometimes severe corneal complications, which are illustrated by material from our own patient archives. Recent findings regarding the lipid composition in the tear film in correlation with that of Meibomian gland secretions and the hypothesis of a biofilm as the basis of chronic blepharitis as a theoretical, not yet proven addition to the previously known pathophysiological factors, are discussed.

Keywords

Meibomian gland dysfunction Keratitis Biofilm Lipids Tear film 

Notes

Danksagung

Die Autoren bedanken sich bei Herrn Dr. Johannes Hädrich für die kritische Durchsicht des Manuskripts und Erstellung der Abb. 6.

Einhaltung ethischer Richtlinien

Interessenkonflikt

C. Auw-Hädrich und T. Reinhard geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH 2017

Authors and Affiliations

  1. 1.Klinik für AugenheilkundeFreiburgDeutschland

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